HUMAN:TGON2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TGOLN2 (synonyms: TGN46, TGN51)
Protein Name(s)	Trans-Golgi network integral membrane protein 2 TGN38 homolog TGN46 TGN48 Trans-Golgi network protein TGN51
External Links
UniProt	O43493
EMBL	AF029316 AF029313 AF029314 AF029315 AF029316 AF029313 AF029314 AF029315 AF029316 AF029313 AF029314 AF029315 U62390 AF027515 AF027516 X94333 AK126465 AK222829 AK223063 AK312479 BX640868 AC093162 CH471053 CH471053 CH471053 BC008461 BC028219
CCDS	CCDS46351.1 CCDS56126.1 CCDS56127.1
RefSeq	NP_001193769.1 NP_001193770.1 NP_001193773.1 NP_006455.2
UniGene	Hs.593382
BioGrid	115864
IntAct	O43493
MINT	MINT-3372343
PhosphoSite	O43493
MaxQB	O43493
PaxDb	O43493
PRIDE	O43493
DNASU	10618
Ensembl	ENST00000377386 ENST00000398263 ENST00000409232 ENST00000444342
GeneID	10618
KEGG	hsa:10618
UCSC	uc002soz.3 uc002spb.3 uc002spc.2 uc021vjw.1
CTD	10618
GeneCards	GC02M085538
H-InvDB	HIX0022878
HGNC	HGNC:15450
HPA	CAB011489 HPA012609 HPA012723
MIM	603062
neXtProt	NX_O43493
PharmGKB	PA37959
eggNOG	NOG86902
GeneTree	ENSGT00530000064712
HOVERGEN	HBG108564
InParanoid	O43493
PhylomeDB	O43493
Reactome	REACT_19400
ChiTaRS	TGOLN2
GeneWiki	TGOLN2
GenomeRNAi	10618
NextBio	35467559
PRO	PR:O43493
Proteomes	UP000005640
Bgee	O43493
ExpressionAtlas	O43493
Genevestigator	O43493
GO	GO:0005794 GO:0016021 GO:0005634 GO:0005886 GO:0005802 GO:0030133
InterPro	IPR026084
PANTHER	PTHR23211

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0000138	Golgi trans cisterna	PMID:19837035^[1]	ECO:0000314			C	Figure S2A - TGN46 is used as a trans-golgi marker for colocalization with GOLPH3	complete CACAO 9722
part_of	GO:0030140	trans-Golgi network transport vesicle	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105079 PANTHER:PTN000575073	C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105079 MGI:MGI:105080 PANTHER:PTN000575073 RGD:620445 UniProtKB:O43493	C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:105080 PANTHER:PTN000575073	C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:23386608^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:22456507^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:18166528^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:27435297^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:22797923^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026084	C	Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	PMID:9422759^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:9422759^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030665	clathrin-coated vesicle membrane	Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8868661 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-8868072 Reactome:R-HSA-8868071 Reactome:R-HSA-8867756 Reactome:R-HSA-8867754 Reactome:R-HSA-8866277	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Dippold, HC et al. (2009) GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell 139 337-51 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ahmedli, NB et al. (2013) Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa. J. Biol. Chem. 288 9742-54 PubMed GONUTS page
↑ Orsi, A et al. (2012) Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy. Mol. Biol. Cell 23 1860-73 PubMed GONUTS page
↑ Ginger, RS et al. (2008) SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis. J. Biol. Chem. 283 5486-95 PubMed GONUTS page
↑ Banushi, B et al. (2016) Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis. Nat Commun 7 12111 PubMed GONUTS page
↑ Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page
↑ ^8.0 ^8.1 Kain, R et al. (1998) Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. J. Biol. Chem. 273 981-8 PubMed GONUTS page

[PMID:19837035-1] Dippold, HC et al. (2009) GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell 139 337-51 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23386608-3] Ahmedli, NB et al. (2013) Dynamics of the rhomboid-like protein RHBDD2 expression in mouse retina and involvement of its human ortholog in retinitis pigmentosa. J. Biol. Chem. 288 9742-54 PubMed GONUTS page

[PMID:22456507-4] Orsi, A et al. (2012) Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy. Mol. Biol. Cell 23 1860-73 PubMed GONUTS page

[PMID:18166528-5] Ginger, RS et al. (2008) SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis. J. Biol. Chem. 283 5486-95 PubMed GONUTS page

[PMID:27435297-6] Banushi, B et al. (2016) Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis. Nat Commun 7 12111 PubMed GONUTS page

[PMID:22797923-7] Hoxhaj, G et al. (2012) ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J. Cell. Sci. 125 4662-75 PubMed GONUTS page

[PMID:9422759-8] 8.0 ^8.1 Kain, R et al. (1998) Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. J. Biol. Chem. 273 981-8 PubMed GONUTS page

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HUMAN:TGON2

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