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HUMAN:TBC15

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TBC1D15
Protein Name(s) TBC1 domain family member 15

GTPase-activating protein RAB7 GAP for RAB7 Rab7-GAP

External Links
UniProt Q8TC07
EMBL AB449901
AK022147
AK297626
AC089984
AC090109
BC028352
CCDS CCDS31858.1
CCDS53814.1
CCDS55849.1
RefSeq NP_001139685.2
NP_001139686.1
NP_073608.4
UniGene Hs.284630
ProteinModelPortal Q8TC07
SMR Q8TC07
BioGrid 122296
IntAct Q8TC07
STRING 9606.ENSP00000318262
PhosphoSite Q8TC07
DMDM 143811467
MaxQB Q8TC07
PaxDb Q8TC07
PRIDE Q8TC07
Ensembl ENST00000319106
ENST00000485960
ENST00000550746
GeneID 64786
KEGG hsa:64786
UCSC uc001swu.3
uc001swv.3
CTD 64786
GeneCards GC12P072233
HGNC HGNC:25694
HPA HPA013388
HPA015592
MIM 612662
neXtProt NX_Q8TC07
PharmGKB PA134946839
eggNOG COG5210
GeneTree ENSGT00550000074386
HOGENOM HOG000012710
HOVERGEN HBG057668
InParanoid Q8TC07
OMA VEDVLCK
OrthoDB EOG7HTHHR
PhylomeDB Q8TC07
TreeFam TF314296
ChiTaRS TBC1D15
GenomeRNAi 64786
NextBio 35534924
PRO PR:Q8TC07
Proteomes UP000005640
Bgee Q8TC07
CleanEx HS_TBC1D15
ExpressionAtlas Q8TC07
Genevestigator Q8TC07
GO GO:0005737
GO:0070062
GO:0005739
GO:0005097
GO:0032851
GO:0032313
InterPro IPR021935
IPR000195
Pfam PF12068
PF00566
SMART SM00164
SUPFAM SSF47923
PROSITE PS50086

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

NOT|involved_in

GO:1902017

regulation of cilium assembly

PMID:17646400[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9CXF4

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9CXF4

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9CXF4

F

Seeded From UniProt

complete

involved_in

GO:0090630

activation of GTPase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000537561
SGD:S000005237
dictyBase:DDB_G0276119
dictyBase:DDB_G0280955

P

Seeded From UniProt

complete

enables

GO:0017137

Rab GTPase binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0031233
FB:FBgn0038129
FB:FBgn0261261
FB:FBgn0262740
MGI:MGI:107320
MGI:MGI:2385326
PANTHER:PTN000537561
UniProtKB:O43147
UniProtKB:O60447
UniProtKB:Q2NKQ1
UniProtKB:Q5R372
UniProtKB:Q8IYX1
UniProtKB:Q92738
UniProtKB:Q96CN4
UniProtKB:Q96HU1
UniProtKB:Q9Y2I9
UniProtKB:Q9Y3P9
WB:WBGene00008018
WB:WBGene00020572
dictyBase:DDB_G0269130
dictyBase:DDB_G0280955

F

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2385326
PANTHER:PTN000537561
SGD:S000003332

P

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0262740
MGI:MGI:1913937
MGI:MGI:2144695
MGI:MGI:2385326
PANTHER:PTN000537561
PomBase:SPAC6F6.08c
SGD:S000002393
SGD:S000003332
SGD:S000003580
SGD:S000004659
SGD:S000005237
SGD:S000005472
SGD:S000005596
SGD:S000006170
UniProtKB:O43147
UniProtKB:O60447
UniProtKB:Q2NKQ1
UniProtKB:Q3MII6
UniProtKB:Q4KMP7
UniProtKB:Q5R372
UniProtKB:Q8TBP0
UniProtKB:Q92738
UniProtKB:Q96CN4
UniProtKB:Q96HU1
UniProtKB:Q9BYX2
UniProtKB:Q9Y2I9
UniProtKB:Q9Y3P9
WB:WBGene00007167
WB:WBGene00022880
dictyBase:DDB_G0269130
dictyBase:DDB_G0276119
dictyBase:DDB_G0280955

F

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CXF4
ensembl:ENSMUSP00000020339

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CXF4
ensembl:ENSMUSP00000020339

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CXF4
ensembl:ENSMUSP00000020339

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CXF4
ensembl:ENSMUSP00000020339

F

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0343

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Yoshimura, S et al. (2007) Functional dissection of Rab GTPases involved in primary cilium formation. J. Cell Biol. 178 363-9 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page