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HUMAN:TASP1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | TASP1 (synonyms: C20orf13) | |
| Protein Name(s) | Threonine aspartase 1
Taspase-1 Threonine aspartase subunit alpha Threonine aspartase subunit beta | |
| External Links | ||
| UniProt | Q9H6P5 | |
| EMBL | AK000219 AK025671 AK299940 AK304488 AK316311 AL050320 AL121754 AL121754 AL121782 AL121782 AL121754 AL133463 AL158089 BC025266 | |
| CCDS | CCDS13116.1 | |
| RefSeq | NP_060184.2 | |
| UniGene | Hs.348297 | |
| PDB | 2A8I 2A8J 2A8L 2A8M | |
| PDBsum | 2A8I 2A8J 2A8L 2A8M | |
| ProteinModelPortal | Q9H6P5 | |
| SMR | Q9H6P5 | |
| BioGrid | 120757 | |
| DIP | DIP-48456N | |
| MINT | MINT-4539345 | |
| STRING | 9606.ENSP00000338624 | |
| BindingDB | Q9H6P5 | |
| ChEMBL | CHEMBL6153 | |
| MEROPS | T02.004 | |
| PhosphoSite | Q9H6P5 | |
| DMDM | 29839766 | |
| MaxQB | Q9H6P5 | |
| PaxDb | Q9H6P5 | |
| PRIDE | Q9H6P5 | |
| DNASU | 55617 | |
| Ensembl | ENST00000337743 | |
| GeneID | 55617 | |
| KEGG | hsa:55617 | |
| UCSC | uc002woi.3 | |
| CTD | 55617 | |
| GeneCards | GC20M013319 | |
| HGNC | HGNC:15859 | |
| HPA | HPA030824 HPA030825 | |
| MIM | 608270 | |
| neXtProt | NX_Q9H6P5 | |
| PharmGKB | PA25671 | |
| eggNOG | COG1446 | |
| GeneTree | ENSGT00530000063034 | |
| HOGENOM | HOG000286029 | |
| HOVERGEN | HBG058647 | |
| InParanoid | Q9H6P5 | |
| KO | K08657 | |
| OMA | VIVLRCC | |
| OrthoDB | EOG78SQHV | |
| PhylomeDB | Q9H6P5 | |
| TreeFam | TF106358 | |
| ChiTaRS | TASP1 | |
| EvolutionaryTrace | Q9H6P5 | |
| GeneWiki | TASP1 | |
| GenomeRNAi | 55617 | |
| NextBio | 35479908 | |
| PRO | PR:Q9H6P5 | |
| Proteomes | UP000005640 | |
| Bgee | Q9H6P5 | |
| CleanEx | HS_TASP1 | |
| ExpressionAtlas | Q9H6P5 | |
| Genevestigator | Q9H6P5 | |
| GO | GO:0004298 GO:0045893 | |
| InterPro | IPR029055 IPR000246 | |
| PANTHER | PTHR10188 | |
| Pfam | PF01112 | |
| SUPFAM | SSF56235 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0090402 |
oncogene-induced senescence |
ECO:0000314 |
P |
Figure 1. |
complete | |||||
| GO:0006508 |
proteolysis |
ECO:0000315 |
P |
Figure 1. |
complete | |||||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045893 |
positive regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004298 |
threonine-type endopeptidase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051604 |
protein maturation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104873 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG12407 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000022480 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004298 |
threonine-type endopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0263602 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004298 |
threonine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004298 |
threonine-type endopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Wünsch, D et al. (2012) Chemico-genetic strategies to inhibit the leukemic potential of threonine aspartase-1. Blood Cancer J 2 e77 PubMed GONUTS page
- ↑ 2.0 2.1 Hsieh, JJ et al. (2003) Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell 115 293-303 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Khan, JA et al. (2005) Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. Structure 13 1443-52 PubMed GONUTS page
