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HUMAN:TACC3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TACC3 (synonyms: ERIC1)
Protein Name(s) Transforming acidic coiled-coil-containing protein 3

ERIC-1

External Links
UniProt Q9Y6A5
EMBL AF093543
AJ243997
BC106071
BC111771
CCDS CCDS3352.1
RefSeq NP_006333.1
UniGene Hs.104019
ProteinModelPortal Q9Y6A5
SMR Q9Y6A5
BioGrid 115723
IntAct Q9Y6A5
MINT MINT-8144915
STRING 9606.ENSP00000326550
iPTMnet Q9Y6A5
PhosphoSite Q9Y6A5
BioMuta TACC3
DMDM 13431939
EPD Q9Y6A5
MaxQB Q9Y6A5
PaxDb Q9Y6A5
PeptideAtlas Q9Y6A5
PRIDE Q9Y6A5
Ensembl ENST00000313288
GeneID 10460
KEGG hsa:10460
UCSC uc003gdo.4
CTD 10460
GeneCards TACC3
HGNC HGNC:11524
HPA CAB010111
HPA005781
HPA022039
MalaCards TACC3
MIM 605303
neXtProt NX_Q9Y6A5
Orphanet 251579
251576
PharmGKB PA36301
eggNOG ENOG410IIVK
ENOG410YMFS
GeneTree ENSGT00530000063855
HOGENOM HOG000294059
HOVERGEN HBG044999
InParanoid Q9Y6A5
KO K14283
OMA SMHGANE
OrthoDB EOG7HB58V
PhylomeDB Q9Y6A5
TreeFam TF333149
GeneWiki TACC3
GenomeRNAi 10460
NextBio 39663
PRO PR:Q9Y6A5
Proteomes UP000005640
Bgee Q9Y6A5
CleanEx HS_TACC3
ExpressionAtlas Q9Y6A5
Genevisible Q9Y6A5
GO GO:0005737
GO:0015630
GO:0030953
GO:0008283
GO:0021987
GO:0042994
GO:0030097
GO:0022027
GO:0000226
GO:0022008
GO:0051726
GO:0032886
GO:0001666
InterPro IPR007707
Pfam PF05010

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007091

metaphase/anaphase transition of mitotic cell cycle

PMID:23532825[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1902850

microtubule cytoskeleton organization involved in mitosis

PMID:23532825[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060236

regulation of mitotic spindle organization

PMID:21297582[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021987

cerebral cortex development

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341163
MGI:MGI:1928899
MGI:MGI:2443510
PANTHER:PTN000357964

P

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341163
MGI:MGI:1928899
MGI:MGI:2443510
PANTHER:PTN001016925

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341163
PANTHER:PTN001016925
PomBase:SPAC890.02c
WB:WBGene00006381

C

Seeded From UniProt

complete

involved_in

GO:0000226

microtubule cytoskeleton organization

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1341163
MGI:MGI:1928899
MGI:MGI:2443510
PANTHER:PTN001016925
UniProtKB:A0A0B4JD97

P

Seeded From UniProt

complete

part_of

GO:0072686

mitotic spindle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007052

mitotic spindle organization

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039915

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0448

C

Seeded From UniProt

complete

part_of

GO:0005819

spindle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0251

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Cheeseman, LP et al. (2013) Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension. J. Cell. Sci. 126 2102-13 PubMed GONUTS page
  2. Booth, DG et al. (2011) A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO J. 30 906-19 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page