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HUMAN:T2R38

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TAS2R38 (synonyms: PTC)
Protein Name(s) Taste receptor type 2 member 38

T2R38 PTC bitter taste receptor Taste receptor type 2 member 61 T2R61

External Links
UniProt P59533
EMBL AF494231
AY114095
AY258598
AY724960
CH236950
CH471070
BC104933
BC104937
CCDS CCDS34765.1
RefSeq NP_789787.4
UniGene Hs.647085
ProteinModelPortal P59533
STRING 9606.ENSP00000331291
PhosphoSite P59533
DMDM 68068016
PaxDb P59533
PRIDE P59533
Ensembl ENST00000547270
GeneID 5726
KEGG hsa:5726
UCSC uc003vwx.1
CTD 5726
GeneCards GC07M141672
H-InvDB HIX0033729
HGNC HGNC:9584
HPA HPA043862
HPA054366
MIM 171200
607751
neXtProt NX_P59533
PharmGKB PA33936
eggNOG NOG43295
GeneTree ENSGT00760000119096
HOGENOM HOG000041379
HOVERGEN HBG098741
InParanoid P59533
KO K08474
OMA HMRTMKV
OrthoDB EOG7J447B
PhylomeDB P59533
TreeFam TF335891
Reactome REACT_18319
REACT_19231
GeneWiki TAS2R38
GenomeRNAi 5726
NextBio 22262
PRO PR:P59533
Proteomes UP000005640
CleanEx HS_TAS2R38
ExpressionAtlas P59533
Genevestigator P59533
GO GO:0016021
GO:0005886
GO:0033038
GO:0001580
InterPro IPR007960
IPR030050
PANTHER PTHR11394
PTHR11394:SF52
Pfam PF05296

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005886

plasma membrane

PMID:12379855[1]

ECO:0000314

C

Fig.2 a

complete
CACAO 8259

part_of

GO:0005886

plasma membrane

PMID:12379855[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0033038

bitter taste receptor activity

PMID:20022913[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:20022913[2]

ECO:0000305

curator inference used in manual assertion

GO:0033038

C

Seeded From UniProt

complete

involved_in

GO:0001580

detection of chemical stimulus involved in sensory perception of bitter taste

PMID:20022913[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0033038

bitter taste receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000149628
UniProtKB:P59533
UniProtKB:P59534
UniProtKB:P59535
UniProtKB:P59536
UniProtKB:P59537
UniProtKB:P59538
UniProtKB:P59539
UniProtKB:P59540
UniProtKB:P59541
UniProtKB:P59542
UniProtKB:P59544
UniProtKB:P59551
UniProtKB:Q2AB81
UniProtKB:Q2AB82
UniProtKB:Q2AB83
UniProtKB:Q7RTR8
UniProtKB:Q9NYV7
UniProtKB:Q9NYV8
UniProtKB:Q9NYV9
UniProtKB:Q9NYW0
UniProtKB:Q9NYW2
UniProtKB:Q9NYW3
UniProtKB:Q9NYW4
UniProtKB:Q9NYW5
UniProtKB:Q9NYW6
UniProtKB:Q9NYW7

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000149628
UniProtKB:P59536
UniProtKB:P59539
UniProtKB:P59542
UniProtKB:P59551
UniProtKB:Q7RTR8

C

Seeded From UniProt

complete

involved_in

GO:0001580

detection of chemical stimulus involved in sensory perception of bitter taste

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000149628
RGD:1359393
UniProtKB:P59533
UniProtKB:P59534
UniProtKB:P59535
UniProtKB:P59536
UniProtKB:P59537
UniProtKB:P59538
UniProtKB:P59539
UniProtKB:P59540
UniProtKB:P59541
UniProtKB:P59542
UniProtKB:P59544
UniProtKB:P59551
UniProtKB:Q7RTR8
UniProtKB:Q9NYV7
UniProtKB:Q9NYV8
UniProtKB:Q9NYV9
UniProtKB:Q9NYW0
UniProtKB:Q9NYW2
UniProtKB:Q9NYW3
UniProtKB:Q9NYW4
UniProtKB:Q9NYW5
UniProtKB:Q9NYW6
UniProtKB:Q9NYW7

P

Seeded From UniProt

complete

involved_in

GO:0001580

detection of chemical stimulus involved in sensory perception of bitter taste

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030050

P

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007960

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007960

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007960
InterPro:IPR030050

C

Seeded From UniProt

complete

enables

GO:0033038

bitter taste receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030050

F

Seeded From UniProt

complete

involved_in

GO:0050909

sensory perception of taste

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007960

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

Reactome:R-HSA-388396

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-749456
Reactome:R-HSA-749454
Reactome:R-HSA-380073
Reactome:R-HSA-3296233

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0050909

sensory perception of taste

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0919

P

Seeded From UniProt

complete

involved_in

GO:0050896

response to stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Bufe, B et al. (2002) The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat. Genet. 32 397-401 PubMed GONUTS page
  2. 2.0 2.1 2.2 Meyerhof, W et al. (2010) The molecular receptive ranges of human TAS2R bitter taste receptors. Chem. Senses 35 157-70 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page