HUMAN:T2R38

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TAS2R38 (synonyms: PTC)
Protein Name(s)	Taste receptor type 2 member 38 T2R38 PTC bitter taste receptor Taste receptor type 2 member 61 T2R61
External Links
UniProt	P59533
EMBL	AF494231 AY114095 AY258598 AY724960 CH236950 CH471070 BC104933 BC104937
CCDS	CCDS34765.1
RefSeq	NP_789787.4
UniGene	Hs.647085
ProteinModelPortal	P59533
STRING	9606.ENSP00000331291
PhosphoSite	P59533
DMDM	68068016
PaxDb	P59533
PRIDE	P59533
Ensembl	ENST00000547270
GeneID	5726
KEGG	hsa:5726
UCSC	uc003vwx.1
CTD	5726
GeneCards	GC07M141672
H-InvDB	HIX0033729
HGNC	HGNC:9584
HPA	HPA043862 HPA054366
MIM	171200 607751
neXtProt	NX_P59533
PharmGKB	PA33936
eggNOG	NOG43295
GeneTree	ENSGT00760000119096
HOGENOM	HOG000041379
HOVERGEN	HBG098741
InParanoid	P59533
KO	K08474
OMA	HMRTMKV
OrthoDB	EOG7J447B
PhylomeDB	P59533
TreeFam	TF335891
Reactome	REACT_18319 REACT_19231
GeneWiki	TAS2R38
GenomeRNAi	5726
NextBio	22262
PRO	PR:P59533
Proteomes	UP000005640
CleanEx	HS_TAS2R38
ExpressionAtlas	P59533
Genevestigator	P59533
GO	GO:0016021 GO:0005886 GO:0033038 GO:0001580
InterPro	IPR007960 IPR030050
PANTHER	PTHR11394 PTHR11394:SF52
Pfam	PF05296

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0005886	plasma membrane	PMID:12379855^[1]	ECO:0000314			C	Fig.2 a	complete CACAO 8259
part_of	GO:0005886	plasma membrane	PMID:12379855^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0033038	bitter taste receptor activity	PMID:20022913^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:20022913^[2]	ECO:0000305	curator inference used in manual assertion	GO:0033038	C	Seeded From UniProt	complete
involved_in	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	PMID:20022913^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0033038	bitter taste receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000149628 UniProtKB:P59533 UniProtKB:P59534 UniProtKB:P59535 UniProtKB:P59536 UniProtKB:P59537 UniProtKB:P59538 UniProtKB:P59539 UniProtKB:P59540 UniProtKB:P59541 UniProtKB:P59542 UniProtKB:P59544 UniProtKB:P59551 UniProtKB:Q2AB81 UniProtKB:Q2AB82 UniProtKB:Q2AB83 UniProtKB:Q7RTR8 UniProtKB:Q9NYV7 UniProtKB:Q9NYV8 UniProtKB:Q9NYV9 UniProtKB:Q9NYW0 UniProtKB:Q9NYW2 UniProtKB:Q9NYW3 UniProtKB:Q9NYW4 UniProtKB:Q9NYW5 UniProtKB:Q9NYW6 UniProtKB:Q9NYW7	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000149628 UniProtKB:P59536 UniProtKB:P59539 UniProtKB:P59542 UniProtKB:P59551 UniProtKB:Q7RTR8	C	Seeded From UniProt	complete
involved_in	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000149628 RGD:1359393 UniProtKB:P59533 UniProtKB:P59534 UniProtKB:P59535 UniProtKB:P59536 UniProtKB:P59537 UniProtKB:P59538 UniProtKB:P59539 UniProtKB:P59540 UniProtKB:P59541 UniProtKB:P59542 UniProtKB:P59544 UniProtKB:P59551 UniProtKB:Q7RTR8 UniProtKB:Q9NYV7 UniProtKB:Q9NYV8 UniProtKB:Q9NYV9 UniProtKB:Q9NYW0 UniProtKB:Q9NYW2 UniProtKB:Q9NYW3 UniProtKB:Q9NYW4 UniProtKB:Q9NYW5 UniProtKB:Q9NYW6 UniProtKB:Q9NYW7	P	Seeded From UniProt	complete
involved_in	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030050	P	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007960	F	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007960	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007960 InterPro:IPR030050	C	Seeded From UniProt	complete
enables	GO:0033038	bitter taste receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030050	F	Seeded From UniProt	complete
involved_in	GO:0050909	sensory perception of taste	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007960	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-380073 Reactome:R-HSA-3296233	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0050909	sensory perception of taste	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0919	P	Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C	Seeded From UniProt	complete
enables	GO:0004930	G protein-coupled receptor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0297	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Bufe, B et al. (2002) The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat. Genet. 32 397-401 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Meyerhof, W et al. (2010) The molecular receptive ranges of human TAS2R bitter taste receptors. Chem. Senses 35 157-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12379855-1] 1.0 ^1.1 Bufe, B et al. (2002) The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat. Genet. 32 397-401 PubMed GONUTS page

[PMID:20022913-2] 2.0 ^2.1 ^2.2 Meyerhof, W et al. (2010) The molecular receptive ranges of human TAS2R bitter taste receptors. Chem. Senses 35 157-70 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:T2R38

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