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HUMAN:STIL

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) STIL (synonyms: SIL)
Protein Name(s) SCL-interrupting locus protein

TAL-1-interrupting locus protein

External Links
UniProt Q15468
EMBL M74558
AF349657
AF349642
AF349643
AF349645
AF349647
AF349649
AF349651
AF349653
AF349656
AF349655
AF349654
AF349652
AF349650
AF349648
AF349646
AF349644
CR749851
AL513322
AL135960
AL135960
AL513322
BC126223
CCDS CCDS41329.1
CCDS548.1
PIR A41685
RefSeq NP_001041631.1
NP_001269865.1
NP_001269866.1
NP_001269867.1
NP_001269868.1
NP_003026.2
XP_006710897.1
XP_011540293.1
XP_011540294.1
UniGene Hs.525198
PDB 4YYP
5LHW
5LHZ
PDBsum 4YYP
5LHW
5LHZ
ProteinModelPortal Q15468
SMR Q15468
BioGrid 112382
DIP DIP-60580N
IntAct Q15468
MINT MINT-8340696
STRING 9606.ENSP00000360944
iPTMnet Q15468
PhosphoSitePlus Q15468
BioMuta STIL
DMDM 122070597
EPD Q15468
MaxQB Q15468
PaxDb Q15468
PeptideAtlas Q15468
PRIDE Q15468
DNASU 6491
Ensembl ENST00000360380
ENST00000371877
GeneID 6491
KEGG hsa:6491
UCSC uc001crd.2
CTD 6491
DisGeNET 6491
GeneCards STIL
GeneReviews STIL
HGNC HGNC:10879
HPA HPA046543
MalaCards STIL
MIM 181590
612703
neXtProt NX_Q15468
OpenTargets ENSG00000123473
Orphanet 2512
99861
PharmGKB PA35780
eggNOG ENOG410IF1P
ENOG4111HAF
GeneTree ENSGT00390000007310
HOGENOM HOG000231284
HOVERGEN HBG079548
InParanoid Q15468
KO K16724
OMA HLFKNVE
OrthoDB EOG091G0KB1
PhylomeDB Q15468
TreeFam TF331178
SIGNOR Q15468
ChiTaRS STIL
GeneWiki STIL
GenomeRNAi 6491
PRO PR:Q15468
Proteomes UP000005640
Bgee ENSG00000123473
CleanEx HS_STIL
ExpressionAtlas Q15468
Genevisible Q15468
GO GO:0005814
GO:0005813
GO:0005737
GO:0005829
GO:0008283
GO:0051298
GO:0007368
GO:0000578
GO:0033504
GO:0030900
GO:0001947
GO:0001701
GO:0007052
GO:0035264
GO:0043066
GO:0001843
GO:0021915
GO:0030903
GO:0071539
GO:0046599
GO:0007224
InterPro IPR026123
PANTHER PTHR15128:SF1
Pfam PF15253

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006303

double-strand break repair via nonhomologous end joining

PMID:28423708[1]

ECO:0000314

P

Description: Figure 6A and B. AD51-dependent HRR had changed much in the presence of STIL (by increasing). NHEJ hadn’t changed much in the presence of STIL.

complete
CACAO 12777

involved_in

GO:0046599

regulation of centriole replication

PMID:22020124[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:22020124[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:25385835[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0035264

multicellular organism growth

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0033504

floor plate development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0030903

notochord development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0030900

forebrain development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0021915

neural tube development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0007368

determination of left/right symmetry

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0001947

heart looping

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0001701

in utero embryonic development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

involved_in

GO:0000578

embryonic axis specification

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q60988

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21399614[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071539

protein localization to centrosome

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001031679
UniProtKB:Q15468

P

Seeded From UniProt

complete

involved_in

GO:0051298

centrosome duplication

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107477
PANTHER:PTN001031679
UniProtKB:Q15468

P

Seeded From UniProt

complete

involved_in

GO:0007224

smoothened signaling pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107477
PANTHER:PTN001031679
ZFIN:ZDB-GENE-020419-39

P

Seeded From UniProt

complete

involved_in

GO:0007052

mitotic spindle organization

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001031679
UniProtKB:Q15468

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001031679
UniProtKB:Q15468

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001031679
UniProtKB:Q15468

C

Seeded From UniProt

complete

involved_in

GO:0071539

protein localization to centrosome

PMID:22349705[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051298

centrosome duplication

PMID:22349705[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051298

centrosome duplication

PMID:22349705[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007052

mitotic spindle organization

PMID:22349705[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005814

centriole

PMID:22349705[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:22349705[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22349705[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:26188084[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15468

F

occurs_in:(GO:0005814)

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:22020124[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15468

F

occurs_in:(GO:0005814)

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

part_of

GO:0005814

centriole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0046

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Rabinowicz, N et al. (2017) Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer. Oncotarget 27380-27392 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Tang, CJ et al. (2011) The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. EMBO J. 30 4790-804 PubMed GONUTS page
  3. ↑ Shiratsuchi, G et al. (2015) RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity. EMBO J. 34 97-114 PubMed GONUTS page
  4. ↑ Jakobsen, L et al. (2011) Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. EMBO J. 30 1520-35 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Vulprecht, J et al. (2012) STIL is required for centriole duplication in human cells. J. Cell. Sci. 125 1353-62 PubMed GONUTS page
  7. ↑ Arquint, C et al. (2015) STIL binding to Polo-box 3 of PLK4 regulates centriole duplication. Elife 4 PubMed GONUTS page
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