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HUMAN:STAM1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) STAM (synonyms: STAM1)
Protein Name(s) Signal transducing adapter molecule 1

STAM-1

External Links
UniProt Q92783
EMBL U43899
EF445033
EF445033
CH471072
CH471072
BC030586
CCDS CCDS7122.1
PIR JC4916
RefSeq NP_003464.1
UniGene Hs.335391
PDB 2L0A
3F1I
3LDZ
PDBsum 2L0A
3F1I
3LDZ
ProteinModelPortal Q92783
SMR Q92783
BioGrid 113722
DIP DIP-37761N
IntAct Q92783
MINT MINT-734093
STRING 9606.ENSP00000366746
PhosphoSite Q92783
DMDM 71153545
MaxQB Q92783
PaxDb Q92783
PRIDE Q92783
Ensembl ENST00000377524
GeneID 8027
KEGG hsa:8027
UCSC uc001ipj.2
CTD 8027
GeneCards GC10P017686
HGNC HGNC:11357
HPA CAB034399
HPA043882
MIM 601899
neXtProt NX_Q92783
PharmGKB PA36179
eggNOG NOG309509
GeneTree ENSGT00700000104139
HOGENOM HOG000231952
HOVERGEN HBG053175
InParanoid Q92783
KO K04705
OMA PDVTIYQ
PhylomeDB Q92783
TreeFam TF315007
Reactome REACT_12484
REACT_27258
SignaLink Q92783
EvolutionaryTrace Q92783
GeneWiki Signal_transducing_adaptor_molecule
GenomeRNAi 8027
NextBio 30597
PRO PR:Q92783
Proteomes UP000005640
Bgee Q92783
CleanEx HS_STAM
ExpressionAtlas Q92783
Genevestigator Q92783
GO GO:0005829
GO:0031901
GO:0005070
GO:0016197
GO:0007173
GO:0006886
GO:0061024
GO:0042059
GO:1903543
GO:0009967
GO:0007165
Gene3D 1.25.40.90
InterPro IPR008942
IPR001452
IPR003903
IPR002014
IPR018205
Pfam PF00018
PF02809
PF00790
PRINTS PR00452
SMART SM00326
SM00726
SM00288
SUPFAM SSF48464
SSF50044
PROSITE PS50002
PS50330
PS50179

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0033565

ESCRT-0 complex

PMID:24790097[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0044389

ubiquitin-like protein ligase binding

PMID:24790097[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8TDB6

F

Seeded From UniProt

complete

involved_in

GO:1903551

regulation of extracellular exosome assembly

PMID:24105262[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903543

positive regulation of exosomal secretion

PMID:24105262[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009967

positive regulation of signal transduction

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005070

P

Seeded From UniProt

complete

involved_in

GO:0006886

intracellular protein transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002014

P

Seeded From UniProt

complete

involved_in

GO:0036258

multivesicular body assembly

PMID:20588296[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016236

macroautophagy

PMID:20588296[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0033565

ESCRT-0 complex

PMID:20588296[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:8780729[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005070

SH3/SH2 adaptor activity

PMID:8780729[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0061024

membrane organization

Reactome:R-HSA-199991

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042059

negative regulation of epidermal growth factor receptor signaling pathway

Reactome:R-HSA-182971

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

Reactome:R-HSA-5688426

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016197

endosomal transport

Reactome:R-HSA-917729

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-917730
Reactome:R-HSA-8875490
Reactome:R-HSA-8871194
Reactome:R-HSA-8871193
Reactome:R-HSA-8869438
Reactome:R-HSA-8868661
Reactome:R-HSA-8868660
Reactome:R-HSA-8868659
Reactome:R-HSA-8868658
Reactome:R-HSA-8868651
Reactome:R-HSA-8868648
Reactome:R-HSA-8868236
Reactome:R-HSA-8868230
Reactome:R-HSA-8868072
Reactome:R-HSA-8868071
Reactome:R-HSA-8867756
Reactome:R-HSA-8867754
Reactome:R-HSA-8867047
Reactome:R-HSA-8867044
Reactome:R-HSA-8867041
Reactome:R-HSA-8866279
Reactome:R-HSA-5693061
Reactome:R-HSA-183072
Reactome:R-HSA-182990
Reactome:R-HSA-182986

ECO:0000304

author statement supported by traceable reference used in manual assertion

























C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0031901

early endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0093

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Holleman, J & Marchese, A (2014) The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Mol. Biol. Cell 25 1892-904 PubMed GONUTS page
  2. ↑ 2.0 2.1 Colombo, M et al. (2013) Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J. Cell. Sci. 126 5553-65 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Hurley, JH & Hanson, PI (2010) Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat. Rev. Mol. Cell Biol. 11 556-66 PubMed GONUTS page
  4. ↑ 4.0 4.1 Takeshita, T et al. (1996) Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. Biochem. Biophys. Res. Commun. 225 1035-9 PubMed GONUTS page
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