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HUMAN:ST1A3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SULT1A3 (synonyms: STM) | |
| Protein Name(s) | Sulfotransferase 1A3
ST1A3 Aryl sulfotransferase 1A3/1A4 Catecholamine-sulfating phenol sulfotransferase HAST3 M-PST Monoamine-sulfating phenol sulfotransferase Placental estrogen sulfotransferase Sulfotransferase 1A3/1A4 Sulfotransferase, monoamine-preferring Thermolabile phenol sulfotransferase TL-PST | |
| External Links | ||
| UniProt | P0DMM9 | |
| EMBL | L19956 L25275 L19956 U20499 X84653 L34160 U37686 U34199 AK122733 AK298073 AC106782 AC133555 AB111094 BC014471 BC078144 U08099 | |
| CCDS | CCDS10674.1 | |
| PIR | A55451 | |
| RefSeq | NP_001017390.1 NP_808220.1 XP_005276563.1 XP_005276564.1 XP_006726684.1 | |
| UniGene | Hs.460558 Hs.744871 | |
| PDB | 1CJM 2A3R | |
| PDBsum | 1CJM 2A3R | |
| DisProt | DP00011 | |
| ProteinModelPortal | P0DMM9 | |
| SMR | P0DMM9 | |
| STRING | 9606.ENSP00000339221 | |
| DMDM | 1711609 | |
| DNASU | 445329 6818 | |
| Ensembl | ENST00000338971 ENST00000395138 ENST00000563322 | |
| GeneID | 101929857 445329 6818 | |
| CTD | 445329 6818 | |
| HGNC | HGNC:11455 | |
| HPA | HPA049500 HPA051051 | |
| MIM | 600641 | |
| neXtProt | NX_P0DMM9 | |
| PharmGKB | PA344 | |
| GeneTree | ENSGT00760000118932 | |
| HOGENOM | HOG000037209 | |
| HOVERGEN | HBG001195 | |
| PhylomeDB | P0DMM9 | |
| TreeFam | TF321745 | |
| BioCyc | MetaCyc:HS05608-MONOMER | |
| BRENDA | 2.8.2.1 | |
| NextBio | 26617 | |
| Proteomes | UP000005640 | |
| CleanEx | HS_SULT1A3 HS_SULT1A4 | |
| GO | GO:0005737 GO:0004062 GO:0008146 GO:0006584 GO:0009812 GO:0008202 GO:0051923 GO:0006805 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR027417 IPR000863 | |
| Pfam | PF00685 | |
| SUPFAM | SSF52540 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0004062 |
aryl sulfotransferase activity |
ECO:0000315 |
F |
Figure 3 compares the dopamine sulfotransferase activity for SULT1A3 wild type and mutants. |
complete | |||||
|
involved_in |
GO:0006068 |
ethanol catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043199 |
sulfate binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1901215 |
negative regulation of neuron death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1903351 |
cellular response to dopamine |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007212 |
dopamine receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070371 |
ERK1 and ERK2 cascade |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0098989 |
NMDA selective glutamate receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097720 |
calcineurin-mediated signaling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047685 |
amine sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:18243) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042420 |
dopamine catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051923 |
sulfation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004062 |
aryl sulfotransferase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051923 |
sulfation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009812 |
flavonoid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008146 |
sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006805 |
xenobiotic metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008146 |
sulfotransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004062 |
aryl sulfotransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
Reactome:R-HSA-156584 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0036498 |
IRE1-mediated unfolded protein response |
Reactome:R-HSA-381070 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-1791108 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0008202 |
steroid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006584 |
catecholamine metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Dajani, R et al. (1998) A single amino acid, glu146, governs the substrate specificity of a human dopamine sulfotransferase, SULT1A3. Mol. Pharmacol. 54 942-8 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Kurogi, K et al. (2012) Ethanol sulfation by the human cytosolic sulfotransferases: a systematic analysis. Biol. Pharm. Bull. 35 2180-5 PubMed GONUTS page
- ↑ Bidwell, LM et al. (1999) Crystal structure of human catecholamine sulfotransferase. J. Mol. Biol. 293 521-30 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Sidharthan, NP et al. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J. Biol. Chem. 288 34364-74 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Brand, W et al. (2010) Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Drug Metab. Dispos. 38 617-25 PubMed GONUTS page
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