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HUMAN:ST1A1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SULT1A1 (synonyms: STP, STP1)
Protein Name(s) Sulfotransferase 1A1

ST1A1 Aryl sulfotransferase 1 HAST1/HAST2 Phenol sulfotransferase 1 Phenol-sulfating phenol sulfotransferase 1 P-PST 1 ST1A3 Thermostable phenol sulfotransferase Ts-PST

External Links
UniProt P50225
EMBL U09031
L19955
L10819
L19999
U26309
X84654
X78283
U71086
U54701
AJ007418
U52852
AB062428
BT007324
CR608214
AC020765
BC000923
BC110887
L15346
CCDS CCDS10637.1
CCDS32420.1
PIR I57945
JC2523
JC5248
S52399
S52794
RefSeq NP_001046.2
NP_803565.1
NP_803566.1
NP_803878.1
NP_803880.1
XP_005255579.1
UniGene Hs.567342
Hs.736805
PDB 1LS6
1Z28
2D06
3QVU
3QVV
3U3J
3U3K
3U3M
3U3O
3U3R
4GRA
PDBsum 1LS6
1Z28
2D06
3QVU
3QVV
3U3J
3U3K
3U3M
3U3O
3U3R
4GRA
ProteinModelPortal P50225
SMR P50225
BioGrid 112686
IntAct P50225
STRING 9606.ENSP00000321988
ChEMBL CHEMBL1743291
DrugBank DB00316
DB00675
PhosphoSite P50225
DMDM 313104286
OGP P50225
MaxQB P50225
PaxDb P50225
PRIDE P50225
DNASU 6817
Ensembl ENST00000314752
ENST00000350842
ENST00000395607
ENST00000395609
ENST00000569554
GeneID 6817
KEGG hsa:6817
UCSC uc002dqi.3
uc002dqm.3
CTD 6817
GeneCards GC16M028616
H-InvDB HIX0017846
HGNC HGNC:11453
MIM 171150
neXtProt NX_P50225
PharmGKB PA343
eggNOG NOG260792
GeneTree ENSGT00760000118932
HOGENOM HOG000037209
HOVERGEN HBG001195
InParanoid P50225
KO K01014
OMA KMAGCKL
OrthoDB EOG7V49ZK
PhylomeDB P50225
TreeFam TF321745
BioCyc MetaCyc:HS09898-MONOMER
BRENDA 2.8.2.1
Reactome REACT_6913
SABIO-RK P50225
EvolutionaryTrace P50225
GeneWiki SULT1A1
GenomeRNAi 6817
NextBio 26605
PRO PR:P50225
Proteomes UP000005640
Bgee P50225
CleanEx HS_SULT1A1
ExpressionAtlas P50225
Genevestigator P50225
GO GO:0005829
GO:0004062
GO:0047894
GO:0050294
GO:0008146
GO:0050427
GO:0009308
GO:0006584
GO:0008210
GO:0009812
GO:0044281
GO:0051923
GO:0006805
Gene3D 3.40.50.300
InterPro IPR027417
IPR000863
Pfam PF00685
SUPFAM SSF52540

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006068

ethanol catabolic process

PMID:23207770[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050427

3'-phosphoadenosine 5'-phosphosulfate metabolic process

PMID:23207770[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051923

sulfation

PMID:23207770[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004062

aryl sulfotransferase activity

PMID:23207770[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051923

sulfation

PMID:20056724[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0047894

flavonol 3-sulfotransferase activity

PMID:20056724[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0009812

flavonoid metabolic process

PMID:20056724[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006805

xenobiotic metabolic process

PMID:20056724[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050294

steroid sulfotransferase activity

PMID:16221673[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0008210

estrogen metabolic process

PMID:16221673[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006805

xenobiotic metabolic process

PMID:12471039[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004062

aryl sulfotransferase activity

PMID:12471039[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051923

sulfation

PMID:19548878[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008146

sulfotransferase activity

PMID:19548878[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008146

sulfotransferase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000863

F

Seeded From UniProt

complete

enables

GO:0004062

aryl sulfotransferase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.8.2.1

F

Seeded From UniProt

complete

involved_in

GO:0009308

amine metabolic process

PMID:8661000[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008146

sulfotransferase activity

PMID:8661000[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050427

3'-phosphoadenosine 5'-phosphosulfate metabolic process

Reactome:R-HSA-156584

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-176646
Reactome:R-HSA-176585
Reactome:R-HSA-176474
Reactome:R-HSA-158860
Reactome:R-HSA-158849
Reactome:R-HSA-158468

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0008202

steroid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0753

P

Seeded From UniProt

complete

involved_in

GO:0006584

catecholamine metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0128

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Kurogi, K et al. (2012) Ethanol sulfation by the human cytosolic sulfotransferases: a systematic analysis. Biol. Pharm. Bull. 35 2180-5 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Brand, W et al. (2010) Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Drug Metab. Dispos. 38 617-25 PubMed GONUTS page
  3. 3.0 3.1 Gamage, NU et al. (2005) The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates. J. Biol. Chem. 280 41482-6 PubMed GONUTS page
  4. 4.0 4.1 Gamage, NU et al. (2003) Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition. J. Biol. Chem. 278 7655-62 PubMed GONUTS page
  5. 5.0 5.1 Senggunprai, L et al. (2009) Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases. Biochem. J. 422 455-62 PubMed GONUTS page
  6. 6.0 6.1 Her, C et al. (1996) Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization. Genomics 33 409-20 PubMed GONUTS page