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HUMAN:ST1A1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | SULT1A1 (synonyms: STP, STP1) | |
Protein Name(s) | Sulfotransferase 1A1
ST1A1 Aryl sulfotransferase 1 HAST1/HAST2 Phenol sulfotransferase 1 Phenol-sulfating phenol sulfotransferase 1 P-PST 1 ST1A3 Thermostable phenol sulfotransferase Ts-PST | |
External Links | ||
UniProt | P50225 | |
EMBL | U09031 L19955 L10819 L19999 U26309 X84654 X78283 U71086 U54701 AJ007418 U52852 AB062428 BT007324 CR608214 AC020765 BC000923 BC110887 L15346 | |
CCDS | CCDS10637.1 CCDS32420.1 | |
PIR | I57945 JC2523 JC5248 S52399 S52794 | |
RefSeq | NP_001046.2 NP_803565.1 NP_803566.1 NP_803878.1 NP_803880.1 XP_005255579.1 | |
UniGene | Hs.567342 Hs.736805 | |
PDB | 1LS6 1Z28 2D06 3QVU 3QVV 3U3J 3U3K 3U3M 3U3O 3U3R 4GRA | |
PDBsum | 1LS6 1Z28 2D06 3QVU 3QVV 3U3J 3U3K 3U3M 3U3O 3U3R 4GRA | |
ProteinModelPortal | P50225 | |
SMR | P50225 | |
BioGrid | 112686 | |
IntAct | P50225 | |
STRING | 9606.ENSP00000321988 | |
ChEMBL | CHEMBL1743291 | |
DrugBank | DB00316 DB00675 | |
PhosphoSite | P50225 | |
DMDM | 313104286 | |
OGP | P50225 | |
MaxQB | P50225 | |
PaxDb | P50225 | |
PRIDE | P50225 | |
DNASU | 6817 | |
Ensembl | ENST00000314752 ENST00000350842 ENST00000395607 ENST00000395609 ENST00000569554 | |
GeneID | 6817 | |
KEGG | hsa:6817 | |
UCSC | uc002dqi.3 uc002dqm.3 | |
CTD | 6817 | |
GeneCards | GC16M028616 | |
H-InvDB | HIX0017846 | |
HGNC | HGNC:11453 | |
MIM | 171150 | |
neXtProt | NX_P50225 | |
PharmGKB | PA343 | |
eggNOG | NOG260792 | |
GeneTree | ENSGT00760000118932 | |
HOGENOM | HOG000037209 | |
HOVERGEN | HBG001195 | |
InParanoid | P50225 | |
KO | K01014 | |
OMA | KMAGCKL | |
OrthoDB | EOG7V49ZK | |
PhylomeDB | P50225 | |
TreeFam | TF321745 | |
BioCyc | MetaCyc:HS09898-MONOMER | |
BRENDA | 2.8.2.1 | |
Reactome | REACT_6913 | |
SABIO-RK | P50225 | |
EvolutionaryTrace | P50225 | |
GeneWiki | SULT1A1 | |
GenomeRNAi | 6817 | |
NextBio | 26605 | |
PRO | PR:P50225 | |
Proteomes | UP000005640 | |
Bgee | P50225 | |
CleanEx | HS_SULT1A1 | |
ExpressionAtlas | P50225 | |
Genevestigator | P50225 | |
GO | GO:0005829 GO:0004062 GO:0047894 GO:0050294 GO:0008146 GO:0050427 GO:0009308 GO:0006584 GO:0008210 GO:0009812 GO:0044281 GO:0051923 GO:0006805 | |
Gene3D | 3.40.50.300 | |
InterPro | IPR027417 IPR000863 | |
Pfam | PF00685 | |
SUPFAM | SSF52540 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0006068 |
ethanol catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051923 |
sulfation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004062 |
aryl sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051923 |
sulfation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0047894 |
flavonol 3-sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009812 |
flavonoid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006805 |
xenobiotic metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0050294 |
steroid sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008210 |
estrogen metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006805 |
xenobiotic metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004062 |
aryl sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051923 |
sulfation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008146 |
sulfotransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008146 |
sulfotransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004062 |
aryl sulfotransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009308 |
amine metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008146 |
sulfotransferase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050427 |
3'-phosphoadenosine 5'-phosphosulfate metabolic process |
Reactome:R-HSA-156584 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-176646 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008202 |
steroid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006584 |
catecholamine metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Kurogi, K et al. (2012) Ethanol sulfation by the human cytosolic sulfotransferases: a systematic analysis. Biol. Pharm. Bull. 35 2180-5 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Brand, W et al. (2010) Phase II metabolism of hesperetin by individual UDP-glucuronosyltransferases and sulfotransferases and rat and human tissue samples. Drug Metab. Dispos. 38 617-25 PubMed GONUTS page
- ↑ 3.0 3.1 Gamage, NU et al. (2005) The structure of human SULT1A1 crystallized with estradiol. An insight into active site plasticity and substrate inhibition with multi-ring substrates. J. Biol. Chem. 280 41482-6 PubMed GONUTS page
- ↑ 4.0 4.1 Gamage, NU et al. (2003) Structure of a human carcinogen-converting enzyme, SULT1A1. Structural and kinetic implications of substrate inhibition. J. Biol. Chem. 278 7655-62 PubMed GONUTS page
- ↑ 5.0 5.1 Senggunprai, L et al. (2009) Inhibitory effects of kynurenic acid, a tryptophan metabolite, and its derivatives on cytosolic sulfotransferases. Biochem. J. 422 455-62 PubMed GONUTS page
- ↑ 6.0 6.1 Her, C et al. (1996) Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization. Genomics 33 409-20 PubMed GONUTS page
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