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HUMAN:SPTN1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SPTAN1 (synonyms: NEAS, SPTA2)
Protein Name(s) Spectrin alpha chain, non-erythrocytic 1

Alpha-II spectrin Fodrin alpha chain Spectrin, non-erythroid alpha subunit

External Links
UniProt Q13813
EMBL J05243
U83867
AB191262
AB209860
AL356481
AL356481
BC053521
M24773
M18627
U26396
AF148808
X86901
CCDS CCDS48036.1
CCDS6905.1
CCDS75914.1
PIR A35715
RefSeq NP_001123910.1
NP_001182461.1
NP_003118.2
UniGene Hs.372331
PDB 2FOT
3F31
3FB2
PDBsum 2FOT
3F31
3FB2
ProteinModelPortal Q13813
SMR Q13813
BioGrid 112587
DIP DIP-33141N
IntAct Q13813
MINT MINT-4999298
PhosphoSite Q13813
DMDM 94730425
MaxQB Q13813
PaxDb Q13813
PRIDE Q13813
Ensembl ENST00000358161
ENST00000372731
ENST00000372739
GeneID 6709
KEGG hsa:6709
UCSC uc004bvl.4
uc004bvm.4
uc004bvn.4
CTD 6709
GeneCards GC09P131314
HGNC HGNC:11273
HPA CAB004581
HPA007927
MIM 182810
613477
neXtProt NX_Q13813
Orphanet 3451
PharmGKB PA36102
eggNOG COG5126
GeneTree ENSGT00760000118813
HOVERGEN HBG059266
InParanoid Q13813
KO K06114
OrthoDB EOG7GXP9K
PhylomeDB Q13813
TreeFam TF343803
Reactome REACT_13541
REACT_18334
REACT_22266
REACT_23832
ChiTaRS SPTAN1
EvolutionaryTrace Q13813
GeneWiki SPTAN1
GenomeRNAi 6709
NextBio 26162
PRO PR:Q13813
Proteomes UP000005640
Bgee Q13813
Genevestigator Q13813
GO GO:0032437
GO:0005829
GO:0070062
GO:0005916
GO:0043231
GO:0016328
GO:0016020
GO:0015630
GO:0008091
GO:0031982
GO:0030018
GO:0003779
GO:0005509
GO:0005200
GO:0051693
GO:0006915
GO:0007411
GO:0006921
Gene3D 1.10.238.10
InterPro IPR011992
IPR014837
IPR018247
IPR002048
IPR001452
IPR018159
IPR013315
IPR002017
Pfam PF13499
PF08726
PF00018
PF00435
PRINTS PR00452
PR01887
SMART SM00054
SM00326
SM00150
SUPFAM SSF50044
PROSITE PS00018
PS50222
PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0045296

cadherin binding

PMID:25468996[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1903561

extracellular vesicle

PMID:24769233[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001359)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007010

cytoskeleton organization

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005200

P

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR002048

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:2307671[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0008091

spectrin

PMID:2307671[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

PMID:2307671[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:2307671[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

GO:0000723

telomere maintenance

PMID:23571757[5]

ECO:0000314

P

Fig 1 shows normal cells that have been transfected and treated for 24 hours with MMC. The arrows show sister chromatid fusions , breaks, and exchanges).(B) A score of 100 metaphase spreads scored for chromosomal aberrations

complete
CACAO 8104

part_of

GO:1904724

tertiary granule lumen

Reactome:R-HSA-6798745

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035580

specific granule lumen

Reactome:R-HSA-6798749

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

Reactome:R-HSA-422475

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

Reactome:R-HSA-199977

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-NUL-420398
Reactome:R-NUL-420388
Reactome:R-HSA-6809011
Reactome:R-HSA-6809010
Reactome:R-HSA-6809006
Reactome:R-HSA-6809003
Reactome:R-HSA-6807877
Reactome:R-HSA-6807875
Reactome:R-HSA-5672965
Reactome:R-HSA-392751
Reactome:R-HSA-392054
Reactome:R-HSA-392053
Reactome:R-HSA-392051
Reactome:R-HSA-202967

ECO:0000304

author statement supported by traceable reference used in manual assertion














C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6798749
Reactome:R-HSA-6798745

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

Reactome:R-HSA-5673001

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051693

actin filament capping

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0117

P

Seeded From UniProt

complete

enables

GO:0005516

calmodulin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0112

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0138

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
  2. ↑ Chiasserini, D et al. (2014) Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset. J Proteomics 106 191-204 PubMed GONUTS page
  3. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Moon, RT & McMahon, AP (1990) Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin. J. Biol. Chem. 265 4427-33 PubMed GONUTS page
  5. ↑ Zhang, P et al. (2013) Non-erythroid alpha spectrin prevents telomere dysfunction after DNA interstrand cross-link damage. Nucleic Acids Res. 41 5321-40 PubMed GONUTS page
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