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HUMAN:SPIT1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SPINT1 (synonyms: HAI1) | |
| Protein Name(s) | Kunitz-type protease inhibitor 1
Hepatocyte growth factor activator inhibitor type 1 HAI-1 | |
| External Links | ||
| UniProt | O43278 | |
| EMBL | AB000095 AY296715 AY358969 BT007425 BC004140 BC018702 | |
| CCDS | CCDS10067.1 CCDS45231.1 | |
| RefSeq | NP_001027539.1 NP_003701.1 NP_857593.1 XP_006720720.1 | |
| UniGene | Hs.233950 | |
| PDB | 1YC0 4ISL 4ISN 4ISO | |
| PDBsum | 1YC0 4ISL 4ISN 4ISO | |
| ProteinModelPortal | O43278 | |
| SMR | O43278 | |
| BioGrid | 112570 | |
| DIP | DIP-37949N | |
| IntAct | O43278 | |
| MINT | MINT-1190358 | |
| STRING | 9606.ENSP00000342098 | |
| MEROPS | I02.007 | |
| PhosphoSite | O43278 | |
| MaxQB | O43278 | |
| PaxDb | O43278 | |
| PRIDE | O43278 | |
| DNASU | 6692 | |
| Ensembl | ENST00000344051 ENST00000562057 | |
| GeneID | 6692 | |
| KEGG | hsa:6692 | |
| UCSC | uc001zna.3 uc001znb.3 | |
| CTD | 6692 | |
| GeneCards | GC15P041136 | |
| HGNC | HGNC:11246 | |
| HPA | HPA006903 | |
| MIM | 605123 | |
| neXtProt | NX_O43278 | |
| PharmGKB | PA36076 | |
| eggNOG | NOG296831 | |
| GeneTree | ENSGT00740000115431 | |
| HOGENOM | HOG000128104 | |
| HOVERGEN | HBG061664 | |
| InParanoid | O43278 | |
| KO | K15619 | |
| OMA | REEECKL | |
| OrthoDB | EOG754HSR | |
| PhylomeDB | O43278 | |
| TreeFam | TF325867 | |
| ChiTaRS | SPINT1 | |
| EvolutionaryTrace | O43278 | |
| GeneWiki | SPINT1 | |
| GenomeRNAi | 6692 | |
| NextBio | 26081 | |
| PRO | PR:O43278 | |
| Proteomes | UP000005640 | |
| Bgee | O43278 | |
| CleanEx | HS_SPINT1 | |
| ExpressionAtlas | O43278 | |
| Genevestigator | O43278 | |
| GO | GO:0005576 GO:0005615 GO:0070062 GO:0016020 GO:0004867 GO:0060670 GO:0030198 GO:0010951 GO:0060674 | |
| Gene3D | 4.10.400.10 4.10.410.10 | |
| InterPro | IPR023415 IPR002172 IPR013980 IPR011106 IPR002223 IPR020901 | |
| Pfam | PF00014 PF00057 PF07502 | |
| PRINTS | PR00759 | |
| SMART | SM00131 SM00192 SM00765 | |
| SUPFAM | SSF57362 SSF57424 | |
| PROSITE | PS00280 PS50279 PS01209 PS50068 PS50986 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001914) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004867 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004867 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004867 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010951 |
negative regulation of endopeptidase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004867 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000178 |
negative regulation of neural precursor cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4V8Q2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071773 |
cellular response to BMP stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4V8Q2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045687 |
positive regulation of glial cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4V8Q2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4V8Q2 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4V8Q2 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060674 |
placenta blood vessel development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R097 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060670 |
branching involved in labyrinthine layer morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R097 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R097 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R097 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001892 |
embryonic placenta development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R097 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001843 |
neural tube closure |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9R097 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004867 |
serine-type endopeptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030414 |
peptidase inhibitor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010466 |
negative regulation of peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Shimomura, T et al. (1997) Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J. Biol. Chem. 272 6370-6 PubMed GONUTS page
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