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HUMAN:SPIR1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SPIRE1 (ECO:0000312 with EMBL:AAI25207.1) (synonyms: KIAA1135, SPIR1) | |
| Protein Name(s) | Protein spire homolog 1
Spir-1 | |
| External Links | ||
| UniProt | Q08AE8 | |
| EMBL | AB032961 AK290180 AL833817 AP001028 AP001029 AP005482 CH471113 BC115005 BC125206 BC125207 AJ277587 | |
| CCDS | CCDS32790.2 CCDS45829.1 CCDS45830.1 | |
| RefSeq | NP_001122098.1 NP_001122099.1 NP_064533.3 | |
| UniGene | Hs.515283 | |
| PDB | 2YLE 2YLF 3R7G 3RBW | |
| PDBsum | 2YLE 2YLF 3R7G 3RBW | |
| ProteinModelPortal | Q08AE8 | |
| SMR | Q08AE8 | |
| BioGrid | 121237 | |
| DIP | DIP-42378N | |
| IntAct | Q08AE8 | |
| MINT | MINT-3975323 | |
| STRING | 9606.ENSP00000387266 | |
| iPTMnet | Q08AE8 | |
| PhosphoSite | Q08AE8 | |
| BioMuta | SPIRE1 | |
| DMDM | 425906061 | |
| EPD | Q08AE8 | |
| MaxQB | Q08AE8 | |
| PaxDb | Q08AE8 | |
| PRIDE | Q08AE8 | |
| Ensembl | ENST00000409402 ENST00000410092 ENST00000440472 ENST00000453447 | |
| GeneID | 56907 | |
| KEGG | hsa:56907 | |
| UCSC | uc002kre.4 | |
| CTD | 56907 | |
| GeneCards | SPIRE1 | |
| HGNC | HGNC:30622 | |
| HPA | HPA040737 HPA040942 | |
| MIM | 609216 | |
| neXtProt | NX_Q08AE8 | |
| PharmGKB | PA134895885 | |
| eggNOG | ENOG410IK9H ENOG4111E0J | |
| GeneTree | ENSGT00390000003058 | |
| HOGENOM | HOG000013039 | |
| HOVERGEN | HBG058898 | |
| InParanoid | Q08AE8 | |
| KO | K02098 | |
| OMA | STGHHRP | |
| OrthoDB | EOG77DJ5G | |
| PhylomeDB | Q08AE8 | |
| TreeFam | TF326239 | |
| ChiTaRS | SPIRE1 | |
| GenomeRNAi | 56907 | |
| PRO | PR:Q08AE8 | |
| Proteomes | UP000005640 | |
| Bgee | Q08AE8 | |
| CleanEx | HS_SPIRE1 | |
| ExpressionAtlas | Q08AE8 | |
| Genevisible | Q08AE8 | |
| GO | GO:0005938 GO:0030659 GO:0005856 GO:0048471 GO:0005886 GO:0030036 GO:0045010 GO:0036089 GO:0051295 GO:0070649 GO:0046907 GO:0040038 GO:0015031 GO:0016192 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR011019 IPR029901 IPR029905 IPR011011 IPR013083 | |
| PANTHER | PTHR21345 PTHR21345:SF2 | |
| Pfam | PF16474 | |
| SMART | SM00750 | |
| SUPFAM | SSF57903 | |
| PROSITE | PS51377 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0031307 |
integral component of mitochondrial outer membrane |
ECO:0000314 |
C |
Figure 2A - Spire1C is localized at the periphery of the mitochondria. Figure 2D - fluorescence assay demonstrated that the N-terminus of Spire1C is exposed to the cytoplasm while the C-terminus is not |
complete | |||||
| GO:0090141 |
positive regulation of mitochondrial fission |
ECO:0000315 |
P |
Figure 4 |
complete | |||||
| GO:0090141 |
positive regulation of mitochondrial fission |
ECO:0000316 |
|
P |
Figure 6C and 6D - cells with overexpression of either Spire1C or INF2 or both display short mitochondria, while cells with knocked down expression of INF2 or mutant Spire1C display tubular mitochondria |
complete | ||||
| GO:0032233 |
positive regulation of actin filament bundle assembly |
ECO:0000315 |
P |
Figure 3 - cells with overexpression of Spire1C show increased actin assembly on mitochondria as compared to control, while cells with overexpression of mutant Spire1C do not show increased actin assembly on mitochondria as compared to control |
complete | |||||
| GO:0051639 |
actin filament network formation |
ECO:0000315 |
P |
Figure 3 - cells with overexpression of Spire1C show increased actin assembly on mitochondria as compared to control, while cells with overexpression of mutant Spire1C do not show increased actin assembly on mitochondria as compared to control |
complete | |||||
|
involved_in |
GO:2000781 |
positive regulation of double-strand break repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070649 |
formin-nucleated actin cable assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070649 |
formin-nucleated actin cable assembly |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051295 |
establishment of meiotic spindle localization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046907 |
intracellular transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0040038 |
polar body extrusion after meiotic divisions |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036089 |
cleavage furrow formation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0032154 |
cleavage furrow |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030659 |
cytoplasmic vesicle membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030036 |
actin cytoskeleton organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016192 |
vesicle-mediated transport |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005938 |
cell cortex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016192 |
vesicle-mediated transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045010 |
actin nucleation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0015031 |
protein transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003779 |
actin binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030659 |
cytoplasmic vesicle membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Manor, U et al. (2015) A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division. Elife 4 PubMed GONUTS page
- ↑ 2.0 2.1 Belin, BJ et al. (2015) DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-½ that promotes efficient DNA repair. [corrected]. Elife 4 e07735 PubMed GONUTS page
- ↑ 3.0 3.1 Pfender, S et al. (2011) Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. Curr. Biol. 21 955-60 PubMed GONUTS page
a
c
e
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0005886 ! plasma membrane
- GO:0040038 ! polar body extrusion after meiotic divisions
- GO:0090141 ! positive regulation of mitochondrial fission
- GO:2000781 ! positive regulation of double-strand break repair
- GO:0032233 ! positive regulation of actin filament bundle assembly
- Primates
- GO:0015031 ! protein transport
