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HUMAN:SPAG5
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SPAG5 | |
| Protein Name(s) | Sperm-associated antigen 5
Astrin Deepest Mitotic spindle-associated protein p126 MAP126 | |
| External Links | ||
| UniProt | Q96R06 | |
| EMBL | AF399910 AF345347 AF063308 BC000322 AL122116 AL137585 | |
| CCDS | CCDS32594.1 | |
| PIR | JC7765 T34542 T46296 | |
| RefSeq | NP_006452.3 | |
| UniGene | Hs.514033 | |
| ProteinModelPortal | Q96R06 | |
| BioGrid | 115861 | |
| DIP | DIP-30998N | |
| IntAct | Q96R06 | |
| MINT | MINT-1350705 | |
| STRING | 9606.ENSP00000323300 | |
| PhosphoSite | Q96R06 | |
| DMDM | 47117278 | |
| MaxQB | Q96R06 | |
| PaxDb | Q96R06 | |
| PRIDE | Q96R06 | |
| Ensembl | ENST00000321765 | |
| GeneID | 10615 | |
| KEGG | hsa:10615 | |
| UCSC | uc002hbq.3 | |
| CTD | 10615 | |
| GeneCards | GC17M026904 | |
| HGNC | HGNC:13452 | |
| HPA | HPA022008 HPA022479 | |
| MIM | 615562 | |
| neXtProt | NX_Q96R06 | |
| PharmGKB | PA134868542 | |
| eggNOG | NOG136856 | |
| GeneTree | ENSGT00400000022377 | |
| HOGENOM | HOG000049113 | |
| HOVERGEN | HBG058119 | |
| InParanoid | Q96R06 | |
| OMA | WMSPLAW | |
| OrthoDB | EOG790G04 | |
| PhylomeDB | Q96R06 | |
| TreeFam | TF336280 | |
| ChiTaRS | SPAG5 | |
| GeneWiki | Sperm_associated_antigen_5 | |
| GenomeRNAi | 10615 | |
| NextBio | 40330 | |
| PRO | PR:Q96R06 | |
| Proteomes | UP000005640 | |
| Bgee | Q96R06 | |
| CleanEx | HS_SPAG5 | |
| ExpressionAtlas | Q96R06 | |
| Genevestigator | Q96R06 | |
| GO | GO:0000777 GO:0005737 GO:0000776 GO:0005815 GO:0035371 GO:0030496 GO:0072686 GO:0000922 GO:0007059 GO:0000070 GO:0051988 GO:0007051 | |
| InterPro | IPR028728 | |
| PANTHER | PTHR15347:SF0 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0051987 |
positive regulation of attachment of spindle microtubules to kinetochore |
ECO:0000315 |
P |
Fig. 1 |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0097431 |
mitotic spindle pole |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072686 |
mitotic spindle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000776 |
kinetochore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090235 |
regulation of metaphase plate congression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032388 |
positive regulation of intracellular transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1905832 |
positive regulation of spindle assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008017 |
microtubule binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071539 |
protein localization to centrosome |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0034451 |
centriolar satellite |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072686 |
mitotic spindle |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051988 |
regulation of attachment of spindle microtubules to kinetochore |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0035371 |
microtubule plus-end |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007051 |
spindle organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000776 |
kinetochore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000070 |
mitotic sister chromatid segregation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051301 |
cell division |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051988 |
regulation of attachment of spindle microtubules to kinetochore |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000775 |
chromosome, centromeric region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005874 |
microtubule |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000776 |
kinetochore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000777 |
condensed chromosome kinetochore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005815 |
microtubule organizing center |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030496 |
midbody |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005819 |
spindle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000922 |
spindle pole |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Manning, AL et al. (2010) CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity. EMBO J. 29 3531-43 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Chu, X et al. (2016) Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle. J. Biol. Chem. 291 20055-67 PubMed GONUTS page
- ↑ 3.0 3.1 Kodani, A et al. (2015) Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife 4 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Dunsch, AK et al. (2011) The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment. J. Cell Biol. 192 959-68 PubMed GONUTS page
c
- Catarrhini
- GO:0007049 ! cell cycle
- GO:0051301 ! cell division
- GO:0034451 ! centriolar satellite
- Chordata
- GO:0005694 ! chromosome
- GO:0000775 ! chromosome, centromeric region
- GO:0007059 ! chromosome segregation
- GO:0000777 ! condensed chromosome kinetochore
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
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