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HUMAN:SOM2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | GH2 | |
| Protein Name(s) | Growth hormone variant
GH-V Growth hormone 2 Placenta-specific growth hormone | |
| External Links | ||
| UniProt | P01242 | |
| EMBL | K00470 J03756 J03756 M38451 J03071 AF006060 AF006061 EU421715 EU421715 EU421715 EU421715 AK312194 AB451332 AB451477 AC040958 CH471109 CH471109 CH471109 CH471109 BC020760 | |
| CCDS | CCDS11647.1 CCDS11648.1 CCDS45757.1 CCDS45758.1 | |
| PIR | A28072 D32435 | |
| RefSeq | NP_002050.1 NP_072050.1 NP_072051.1 NP_072052.1 | |
| UniGene | Hs.406754 Hs.654390 | |
| ProteinModelPortal | P01242 | |
| SMR | P01242 | |
| BioGrid | 108956 | |
| STRING | 9606.ENSP00000333157 | |
| PaxDb | P01242 | |
| PRIDE | P01242 | |
| DNASU | 2689 | |
| Ensembl | ENST00000332800 ENST00000423893 ENST00000449787 ENST00000456543 | |
| GeneID | 2689 | |
| KEGG | hsa:2689 | |
| UCSC | uc002jcl.2 uc002jcm.2 uc002jcn.2 uc002jco.2 | |
| CTD | 2689 | |
| GeneCards | GC17M061957 | |
| HGNC | HGNC:4262 | |
| HPA | HPA043715 | |
| MIM | 139240 | |
| neXtProt | NX_P01242 | |
| PharmGKB | PA28672 | |
| eggNOG | NOG26152 | |
| GeneTree | ENSGT00730000111012 | |
| HOGENOM | HOG000068443 | |
| HOVERGEN | HBG011318 | |
| InParanoid | P01242 | |
| KO | K05438 | |
| OMA | RTTMTHC | |
| OrthoDB | EOG7F7W9X | |
| PhylomeDB | P01242 | |
| TreeFam | TF332592 | |
| Reactome | REACT_111133 REACT_115697 | |
| ChiTaRS | GH2 | |
| GeneWiki | Growth_hormone_2 | |
| GenomeRNAi | 2689 | |
| NextBio | 10626 | |
| PRO | PR:P01242 | |
| Proteomes | UP000005640 | |
| Bgee | P01242 | |
| CleanEx | HS_GH2 | |
| Genevestigator | P01242 | |
| GO | GO:0005576 GO:0005179 GO:0060397 | |
| Gene3D | 1.20.1250.10 | |
| InterPro | IPR009079 IPR012351 IPR001400 IPR018116 | |
| PANTHER | PTHR11417 | |
| Pfam | PF00103 | |
| PRINTS | PR00836 | |
| SUPFAM | SSF47266 | |
| PROSITE | PS00266 PS00338 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0060396 |
growth hormone receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000151954 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000151954 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048513 |
animal organ development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000151954 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046427 |
positive regulation of receptor signaling pathway via JAK-STAT |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97762 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045927 |
positive regulation of growth |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000151954 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000151954 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031667 |
response to nutrient levels |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000151829 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000151954 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1341833 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1341833 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005131 |
growth hormone receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:95707 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005179 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005179 |
hormone activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060397 |
growth hormone receptor signaling pathway via JAK-STAT |
Reactome:R-HSA-982772 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031904 |
endosome lumen |
Reactome:R-HSA-1170539 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-982810 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0005179 |
hormone activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Sundström, M et al. (1996) Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution. J. Biol. Chem. 271 32197-203 PubMed GONUTS page
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