HUMAN:SNX9

Species (Taxon ID)	Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus).Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus).Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus).Homo sapiens (Human). (9606)
Gene Name(s)	SNX9 (synonyms: SH3PX1, SH3PXD3A)
Protein Name(s)	Core gene UL49A family protein (ECO:0000313 with EMBL:ADQ57934.1) Envelope glycoprotein gN (ECO:0000313 with EMBL:ADB08208.1) ORF 53 (ECO:0000313 with EMBL:AAB62662.1) ORF53 (ECO:0000313 with EMBL:ACY00452.1) Thymidine kinase (ECO:0000256 with HAMAP-Rule:MF_04029, ECO:0000256 with RuleBase:RU361256) ORF 45 (ECO:0000313 with EMBL:AAB62652.1) ORF45 protein (ECO:0000313 with EMBL:ADQ57925.1) Sorting nexin-9 SH3 and PX domain-containing protein 1 Protein SDP1 SH3 and PX domain-containing protein 3A
External Links
UniProt	Q76RG4
EMBL	U93872 GQ994935 GU233117 GU233118 GU233119 GU233120 GU233121 GU233122 GU233123 GU233124 HQ404500 JX228174 JQ619843 KF588566 KT271461 KT271463 LC200586 LC200587 LC200588 LC200589 U40377 U93872 GQ994935 HQ404500 JX228174 JQ619843 KF588566 U93872 AF091346 AY131198 GQ994935 HQ404500 JX228174 KF588566 AF121859 AF131214 AF172847 AL035634 AL139330 AL391863 BC001084 BC005022 AF076957
RefSeq	YP_001129406.1 YP_001129374.1 YP_001129397.1 NP_057308.1
IntAct	Q76RG4 Q98143 Q77UV9 Q9Y5X1
GeneID	4961468 4961484 4961474 51429
KEGG	vg:4961468 vg:4961484 vg:4961474 hsa:51429
OrthoDB	60at10379 10212at10239 811995at2759
Proteomes	UP000097197 UP000141755 UP000146550 UP000155579 UP000097197 UP000141755 UP000146550 UP000155579 UP000141755 UP000146550 UP000155579 UP000005640
GO	GO:0016021 GO:0019031 GO:0005524 GO:0004797 GO:0071897 GO:0006230 GO:0030136 GO:0032437 GO:0005737 GO:0031410 GO:0030659 GO:0005829 GO:0070062 GO:0031234 GO:0005886 GO:0001726 GO:0005802 GO:0005545 GO:0071933 GO:0045296 GO:0042802 GO:0035091 GO:0042803 GO:0031625 GO:0036089 GO:0006897 GO:0016197 GO:0006886 GO:0060988 GO:0061024 GO:0000281 GO:0097320 GO:0030838 GO:0043547 GO:0051044 GO:0045860 GO:0032461 GO:0006898
HAMAP	MF_04037 MF_04029
InterPro	IPR005211 IPR034707 IPR001889 IPR013672 IPR027417 IPR027267 IPR001683 IPR036871 IPR036028 IPR001452 IPR028644 IPR037425 IPR014536 IPR037426 IPR035558 IPR039358 IPR019497
Pfam	PF03554 PF00693 PF08465 PF10456 PF00787 PF00018
SUPFAM	SSF52540 SSF50044 SSF64268
KO	K21859 K17923
CCDS	CCDS5253.1
UniGene	Hs.191213
PDB	2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE
PDBsum	2RAI 2RAJ 2RAK 3DYT 3DYU 3LGE
ProteinModelPortal	Q9Y5X1
SMR	Q9Y5X1
BioGrid	119535
DIP	DIP-30997N
MINT	Q9Y5X1
STRING	9606.ENSP00000376024
iPTMnet	Q9Y5X1
PhosphoSitePlus	Q9Y5X1
BioMuta	SNX9
DMDM	12643956
EPD	Q9Y5X1
jPOST	Q9Y5X1
MaxQB	Q9Y5X1
PaxDb	Q9Y5X1
PeptideAtlas	Q9Y5X1
PRIDE	Q9Y5X1
ProteomicsDB	86526
DNASU	51429
Ensembl	ENST00000392185
UCSC	uc003qqv.3
CTD	51429
DisGeNET	51429
EuPathDB	HostDB:ENSG00000130340.14
GeneCards	SNX9
HGNC	HGNC:14973
HPA	HPA031410 HPA057203
MIM	605952
neXtProt	NX_Q9Y5X1
OpenTargets	ENSG00000130340
PharmGKB	PA37949
eggNOG	KOG2528 ENOG410XPHZ
GeneTree	ENSGT00940000156557
HOGENOM	HOG000261633
HOVERGEN	HBG009996
InParanoid	Q9Y5X1
OMA	RNTSNNW
PhylomeDB	Q9Y5X1
TreeFam	TF314082
Reactome	R-HSA-432722 R-HSA-8856828
SignaLink	Q9Y5X1
SIGNOR	Q9Y5X1
ChiTaRS	SNX9
EvolutionaryTrace	Q9Y5X1
GeneWiki	SNX9
GenomeRNAi	51429
PRO	PR:Q9Y5X1
Bgee	ENSG00000130340
ExpressionAtlas	Q9Y5X1
Genevisible	Q9Y5X1
CDD	cd07668 cd07285 cd11898
Gene3D	1.20.1270.60 3.30.1520.10
PANTHER	PTHR10555 PTHR10555:SF14
PIRSF	PIRSF027744
SMART	SM00312 SM00326
PROSITE	PS50195 PS50002

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
colocalizes_with	GO:0032437	cuticular plate	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VH2	C		Seeded From UniProt	complete
involved_in	GO:0030838	positive regulation of actin filament polymerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q91VH2	P		Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0071933	Arp2/3 complex binding	PMID:18388313^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	PMID:18388313^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097320	plasma membrane tubulation	PMID:18388313^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045860	positive regulation of protein kinase activity	PMID:18388313^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18388313^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18388313^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	PMID:18353773^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0060988	lipid tube assembly	PMID:17948057^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	PMID:15703209^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17948057^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y5X1	F		Seeded From UniProt	complete
involved_in	GO:0036089	cleavage furrow formation	PMID:22718350^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032461	positive regulation of protein oligomerization	PMID:15703209^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:20491914^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96J02	F		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	PMID:15703209^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:17948057^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0030136	clathrin-coated vesicle	PMID:15703209^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016197	endosomal transport	PMID:22718350^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:22718350^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:15703209^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006898	receptor-mediated endocytosis	PMID:15703209^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	PMID:22718350^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	PMID:15703209^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:15703209^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005545	1-phosphatidylinositol binding	PMID:17948057^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	PMID:22718350^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23085988^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y5X1	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18940612^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y5X1	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH2 ensembl:ENSMUSP00000002436	F		Seeded From UniProt	complete
part_of	GO:0032437	cuticular plate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH2 ensembl:ENSMUSP00000002436	C		Seeded From UniProt	complete
involved_in	GO:0030838	positive regulation of actin filament polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH2 ensembl:ENSMUSP00000002436	P		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH2 ensembl:ENSMUSP00000002436	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH2 ensembl:ENSMUSP00000002436	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q91VH2 ensembl:ENSMUSP00000002436	C		Seeded From UniProt	complete
involved_in	GO:0000278	mitotic cell cycle	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014536	P		Seeded From UniProt	complete
involved_in	GO:0000281	mitotic cytokinesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028644 InterPro:IPR037425 InterPro:IPR037426	P		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028644 InterPro:IPR037425 InterPro:IPR037426	P		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028644 InterPro:IPR037425 InterPro:IPR037426	P		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014536	P		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001683 InterPro:IPR028644 InterPro:IPR036871 InterPro:IPR037425 InterPro:IPR037426	F		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	Reactome:R-HSA-199991	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8871194 Reactome:R-HSA-8871193 Reactome:R-HSA-8869438 Reactome:R-HSA-8868661 Reactome:R-HSA-8868660 Reactome:R-HSA-8868659 Reactome:R-HSA-8868658 Reactome:R-HSA-8868651 Reactome:R-HSA-8868648 Reactome:R-HSA-8868236 Reactome:R-HSA-8868230 Reactome:R-HSA-8867754	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
involved_in	GO:0015031	protein transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0653	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0030136	clathrin-coated vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0070	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0089	C		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0300	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Shin, N et al. (2008) SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. J. Cell. Sci. 121 1252-63 PubMed GONUTS page
↑ Schöbel, S et al. (2008) A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 283 14257-68 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Pylypenko, O et al. (2007) The PX-BAR membrane-remodeling unit of sorting nexin 9. EMBO J. 26 4788-800 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Soulet, F et al. (2005) SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol. Biol. Cell 16 2058-67 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ma, MP & Chircop, M (2012) SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. J. Cell. Sci. 125 4372-82 PubMed GONUTS page
↑ Baumann, C et al. (2010) The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain. FEBS J. 277 2803-14 PubMed GONUTS page
↑ van Weering, JR et al. (2012) Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J. 31 4466-80 PubMed GONUTS page
↑ Wang, Q et al. (2008) Structure and plasticity of Endophilin and Sorting Nexin 9. Structure 16 1574-87 PubMed GONUTS page

[PMID:25468996-1] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:18388313-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Shin, N et al. (2008) SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2. J. Cell. Sci. 121 1252-63 PubMed GONUTS page

[PMID:18353773-3] Schöbel, S et al. (2008) A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J. Biol. Chem. 283 14257-68 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:17948057-5] 5.0 ^5.1 ^5.2 ^5.3 Pylypenko, O et al. (2007) The PX-BAR membrane-remodeling unit of sorting nexin 9. EMBO J. 26 4788-800 PubMed GONUTS page

[PMID:15703209-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 Soulet, F et al. (2005) SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Mol. Biol. Cell 16 2058-67 PubMed GONUTS page

[PMID:22718350-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ma, MP & Chircop, M (2012) SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis. J. Cell. Sci. 125 4372-82 PubMed GONUTS page

[PMID:20491914-8] Baumann, C et al. (2010) The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain. FEBS J. 277 2803-14 PubMed GONUTS page

[PMID:23085988-9] van Weering, JR et al. (2012) Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules. EMBO J. 31 4466-80 PubMed GONUTS page

[PMID:18940612-10] Wang, Q et al. (2008) Structure and plasticity of Endophilin and Sorting Nexin 9. Structure 16 1574-87 PubMed GONUTS page

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HUMAN:SNX9

Contents

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References

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