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HUMAN:SLIT3

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SLIT3 (synonyms: KIAA0814, MEGF5, SLIL2)
Protein Name(s) Slit homolog 3 protein

Slit-3 Multiple epidermal growth factor-like domains protein 5 Multiple EGF-like domains protein 5

External Links
UniProt O75094
EMBL AB017169
AB011538
AY358884
AC008409
AC008479
AC011365
AC011389
AC027311
AC094081
AC112165
BC146759
AL122074
AF075240
CCDS CCDS4369.1
CCDS64311.1
PIR T34555
RefSeq NP_001258875.1
NP_003053.1
UniGene Hs.552087
ProteinModelPortal O75094
SMR O75094
BioGrid 112473
IntAct O75094
MINT MINT-2797284
STRING 9606.ENSP00000332164
PhosphoSite O75094
MaxQB O75094
PaxDb O75094
PRIDE O75094
Ensembl ENST00000332966
ENST00000519560
GeneID 6586
KEGG hsa:6586
UCSC uc003mab.4
CTD 6586
GeneCards GC05M168088
H-InvDB HIX0005394
HGNC HGNC:11087
HPA HPA051630
MIM 603745
neXtProt NX_O75094
PharmGKB PA35940
eggNOG COG4886
GeneTree ENSGT00760000118786
HOGENOM HOG000116120
HOVERGEN HBG057959
InParanoid O75094
KO K06850
OMA EYVCPGP
OrthoDB EOG78WKQW
PhylomeDB O75094
TreeFam TF332887
Reactome REACT_22237
ChiTaRS SLIT3
GeneWiki SLIT3
GenomeRNAi 6586
NextBio 25629
PRO PR:O75094
Proteomes UP000005640
Bgee O75094
CleanEx HS_SLIT3
Genevestigator O75094
GO GO:0005615
GO:0005739
GO:0005509
GO:0048495
GO:0061364
GO:0048846
GO:0007411
GO:0032870
GO:0050919
GO:0030308
GO:0008285
GO:0070100
GO:0010629
GO:0009887
GO:0051414
GO:0035385
Gene3D 2.60.120.200
InterPro IPR013320
IPR000483
IPR006207
IPR000742
IPR001881
IPR013032
IPR000152
IPR018097
IPR009030
IPR001791
IPR001611
IPR003591
IPR000372
Pfam PF00008
PF12661
PF02210
PF13855
PF01463
PF01462
SMART SM00041
SM00181
SM00179
SM00282
SM00369
SM00082
SM00013
SUPFAM SSF49899
SSF57184
PROSITE PS01185
PS01225
PS00022
PS01186
PS50026
PS01187
PS50025
PS51450

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0060412

ventricular septum morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WVB4

P

Seeded From UniProt

complete

involved_in

GO:0003181

atrioventricular valve morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WVB4

P

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WVB4

P

Seeded From UniProt

complete

involved_in

GO:0070100

negative regulation of chemokine-mediated signaling pathway

PMID:18829537[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035385

Roundabout signaling pathway

PMID:18829537[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030308

negative regulation of cell growth

PMID:18829537[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0061364

apoptotic process involved in luteolysis

PMID:18566128[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051414

response to cortisol

PMID:18566128[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050919

negative chemotaxis

PMID:11748139[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048846

axon extension involved in axon guidance

PMID:16840550[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0048495

Roundabout binding

PMID:15207848[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9HCK4

F

Seeded From UniProt

complete

enables

GO:0048495

Roundabout binding

PMID:15207848[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9Y6N7

F

Seeded From UniProt

complete

involved_in

GO:0032870

cellular response to hormone stimulus

PMID:18566128[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|involved_in

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

PMID:11748139[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

PMID:11748139[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:11443047[6]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:19741192[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:9813312[8]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0060412

ventricular septum morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVB4
ensembl:ENSMUSP00000066857

P

Seeded From UniProt

complete

involved_in

GO:0010629

negative regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVB4
ensembl:ENSMUSP00000066857

P

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVB4
ensembl:ENSMUSP00000066857

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVB4
ensembl:ENSMUSP00000066857

P

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVB4
ensembl:ENSMUSP00000066857

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVB4
ensembl:ENSMUSP00000066857

C

Seeded From UniProt

complete

involved_in

GO:0003181

atrioventricular valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVB4
ensembl:ENSMUSP00000066857

P

Seeded From UniProt

complete

involved_in

GO:0003180

aortic valve morphogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVB4
ensembl:ENSMUSP00000066857

P

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001881
InterPro:IPR018097

F

Seeded From UniProt

complete

involved_in

GO:0030154

cell differentiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0221

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0524

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Marlow, R et al. (2008) SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. Cancer Res. 68 7819-27 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Dickinson, RE et al. (2008) Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women. Endocrinology 149 5024-34 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Patel, K et al. (2001) Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons. Development 128 5031-7 PubMed GONUTS page
  4. ↑ Lin, L & Isacson, O (2006) Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. Stem Cells 24 2504-13 PubMed GONUTS page
  5. ↑ 5.0 5.1 Liu, Z et al. (2004) Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol. Cell. Neurosci. 26 232-40 PubMed GONUTS page
  6. ↑ Little, MH et al. (2001) Dual trafficking of Slit3 to mitochondria and cell surface demonstrates novel localization for Slit protein. Am. J. Physiol., Cell Physiol. 281 C486-95 PubMed GONUTS page
  7. ↑ Zhang, B et al. (2009) Repulsive axon guidance molecule Slit3 is a novel angiogenic factor. Blood 114 4300-9 PubMed GONUTS page
  8. ↑ Itoh, A et al. (1998) Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain Res. Mol. Brain Res. 62 175-86 PubMed GONUTS page
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