HUMAN:SLIT2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SLIT2 (synonyms: SLIL3)
Protein Name(s)	Slit homolog 2 protein Slit-2 Slit homolog 2 protein N-product Slit homolog 2 protein C-product
External Links
UniProt	O94813
EMBL	AB017168 AF055585 AF133270 CH471069 BC117190 BC143978
CCDS	CCDS3426.1 CCDS75110.1 CCDS75111.1
RefSeq	NP_001276064.1 NP_001276065.1 NP_004778.1
UniGene	Hs.29802
PDB	2V70 2V9S 2V9T 2WFH
PDBsum	2V70 2V9S 2V9T 2WFH
ProteinModelPortal	O94813
SMR	O94813
BioGrid	114756
DIP	DIP-38198N
IntAct	O94813
MINT	MINT-6768470
STRING	9606.ENSP00000273739
PhosphoSite	O94813
MaxQB	O94813
PaxDb	O94813
PRIDE	O94813
GeneID	9353
KEGG	hsa:9353
UCSC	uc003gpr.1 uc003gps.1
CTD	9353
GeneCards	GC04P020254
HGNC	HGNC:11086
HPA	CAB007590 HPA019511 HPA023088
MIM	603746
neXtProt	NX_O94813
PharmGKB	PA35939
eggNOG	COG4886
GeneTree	ENSGT00760000118786
HOGENOM	HOG000116120
HOVERGEN	HBG057959
InParanoid	O94813
KO	K06839
OrthoDB	EOG78WKQW
PhylomeDB	O94813
TreeFam	TF332887
Reactome	REACT_19226 REACT_19230 REACT_19342 REACT_19351 REACT_19376 REACT_22237
ChiTaRS	SLIT2
EvolutionaryTrace	O94813
GeneWiki	SLIT2
GenomeRNAi	9353
NextBio	35025
PRO	PR:O94813
Proteomes	UP000005640
Bgee	O94813
CleanEx	HS_SLIT2
ExpressionAtlas	O94813
Genevestigator	O94813
GO	GO:0009986 GO:0005737 GO:0005576 GO:0005615 GO:0070062 GO:0016020 GO:0005886 GO:0005509 GO:0045499 GO:0005095 GO:0008201 GO:0042802 GO:0043237 GO:0042803 GO:0043394 GO:0048495 GO:0061364 GO:0048846 GO:0007411 GO:0048754 GO:0002042 GO:0071504 GO:0032870 GO:0021836 GO:0021972 GO:0033563 GO:0001701 GO:0050929 GO:0060763 GO:0001656 GO:0008045 GO:0050919 GO:0030837 GO:0030517 GO:0043086 GO:0030308 GO:0030336 GO:0008285 GO:0090288 GO:0070100 GO:0010596 GO:0010629 GO:0010593 GO:0002689 GO:0090027 GO:0071676 GO:0090024 GO:0001933 GO:0090260 GO:0051058 GO:0071672 GO:0014912 GO:0043116 GO:0043065 GO:0050772 GO:0051414 GO:0031290 GO:0035385 GO:0016337 GO:0001657
Gene3D	2.60.120.200
InterPro	IPR013320 IPR000483 IPR006207 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR003645 IPR001791 IPR001611 IPR003591 IPR000372
Pfam	PF00008 PF02210 PF00560 PF13855 PF01463 PF01462
SMART	SM00041 SM00181 SM00179 SM00274 SM00282 SM00369 SM00082 SM00013
SUPFAM	SSF49899
PROSITE	PS00010 PS01185 PS01225 PS00022 PS01186 PS50026 PS01187 PS50025 PS51450

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060412	ventricular septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R1B9	P		Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R1B9	P	occurs_in:(UBERON:0011742)	Seeded From UniProt	complete
involved_in	GO:0003184	pulmonary valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9R1B9	P	occurs_in:(UBERON:0011745)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0090288	negative regulation of cellular response to growth factor stimulus	PMID:16439689^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090027	negative regulation of monocyte chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9WVC1	P		Seeded From UniProt	complete
involved_in	GO:0071676	negative regulation of mononuclear cell migration	PMID:16439689^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071672	negative regulation of smooth muscle cell chemotaxis	PMID:16439689^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070100	negative regulation of chemokine-mediated signaling pathway	PMID:18829537^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035385	Roundabout signaling pathway	PMID:18829537^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035385	Roundabout signaling pathway	PMID:10102268^[4]	ECO:0000305	curator inference used in manual assertion	GO:0048495	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:18829537^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021972	corticospinal neuron axon guidance through spinal cord	PMID:10975526^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014912	negative regulation of smooth muscle cell migration	PMID:16439689^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	PMID:19351956^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090260	negative regulation of retinal ganglion cell axon guidance	PMID:17062560^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090024	negative regulation of neutrophil chemotaxis	PMID:19759280^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071504	cellular response to heparin	PMID:17062560^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061364	apoptotic process involved in luteolysis	PMID:18566128^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051414	response to cortisol	PMID:18566128^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051058	negative regulation of small GTPase mediated signal transduction	PMID:16439689^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050929	induction of negative chemotaxis	PMID:10197527^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	PMID:19005219^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	PMID:11748139^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048846	axon extension involved in axon guidance	PMID:16840550^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	PMID:19005219^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	PMID:18345009^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0048495	Roundabout binding	PMID:15207848^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HCK4	F		Seeded From UniProt	complete
enables	GO:0048495	Roundabout binding	PMID:15207848^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y6N7	F		Seeded From UniProt	complete
enables	GO:0048495	Roundabout binding	PMID:17848514^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y6N7	F		Seeded From UniProt	complete
enables	GO:0048495	Roundabout binding	PMID:10102268^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9QZI3	F		Seeded From UniProt	complete
enables	GO:0048495	Roundabout binding	PMID:10102268^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O55005	F		Seeded From UniProt	complete
enables	GO:0043394	proteoglycan binding	PMID:11375980^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35053	F		Seeded From UniProt	complete
enables	GO:0043237	laminin-1 binding	PMID:10102268^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043116	negative regulation of vascular permeability	PMID:18345009^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:18566128^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19498462^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032870	cellular response to hormone stimulus	PMID:18566128^[9]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031290	retinal ganglion cell axon guidance	PMID:19498462^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031290	retinal ganglion cell axon guidance	PMID:10864954^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030837	negative regulation of actin filament polymerization	PMID:19759280^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:18566128^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	PMID:19005219^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration	PMID:15207848^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	PMID:11748139^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:16439689^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010596	negative regulation of endothelial cell migration	PMID:18345009^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010593	negative regulation of lamellipodium assembly	PMID:16439689^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:17062560^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:10102268^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:11748139^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18566128^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16439689^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19005219^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:9813312^[20]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005095	GTPase inhibitor activity	PMID:19759280^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005095	GTPase inhibitor activity	PMID:16439689^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002689	negative regulation of leukocyte chemotaxis	PMID:11309622^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	PMID:18345009^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	PMID:15130495^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031290	retinal ganglion cell axon guidance	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1315205 PANTHER:PTN000690516 UniProtKB:O94813	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:21873635^[23]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000690516 UniProtKB:O94813	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19498462^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O94813	F		Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005095	P		Seeded From UniProt	complete
involved_in	GO:0034260	negative regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005095	P		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR018097	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:10102268^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10102268^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050772	positive regulation of axonogenesis	PMID:10197527^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-9010914 Reactome:R-NUL-428519 Reactome:R-NUL-428517 Reactome:R-HSA-9010872 Reactome:R-HSA-9010815 Reactome:R-HSA-8986258 Reactome:R-HSA-8985591 Reactome:R-HSA-428888 Reactome:R-HSA-428534 Reactome:R-HSA-428518 Reactome:R-HSA-376149 Reactome:R-HSA-376141 Reactome:R-HSA-204364	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-NUL-9010914 Reactome:R-HSA-428518 Reactome:R-HSA-376149	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0145	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Liu, D et al. (2006) Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation. Circ. Res. 98 480-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Marlow, R et al. (2008) SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. Cancer Res. 68 7819-27 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Brose, K et al. (1999) Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96 795-806 PubMed GONUTS page
↑ Zou, Y et al. (2000) Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell 102 363-75 PubMed GONUTS page
↑ Urbich, C et al. (2009) HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood 113 5669-79 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Hussain, SA et al. (2006) A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. J. Biol. Chem. 281 39693-8 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Tole, S et al. (2009) The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils. J. Leukoc. Biol. 86 1403-15 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Dickinson, RE et al. (2008) Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women. Endocrinology 149 5024-34 PubMed GONUTS page
↑ ^10.0 ^10.1 Nguyen Ba-Charvet, KT et al. (1999) Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. Neuron 22 463-73 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Stella, MC et al. (2009) The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis. Mol. Biol. Cell 20 642-57 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Patel, K et al. (2001) Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons. Development 128 5031-7 PubMed GONUTS page
↑ Lin, L & Isacson, O (2006) Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. Stem Cells 24 2504-13 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Jones, CA et al. (2008) Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat. Med. 14 448-53 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Liu, Z et al. (2004) Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol. Cell. Neurosci. 26 232-40 PubMed GONUTS page
↑ Morlot, C et al. (2007) Structural insights into the Slit-Robo complex. Proc. Natl. Acad. Sci. U.S.A. 104 14923-8 PubMed GONUTS page
↑ Ronca, F et al. (2001) Characterization of Slit protein interactions with glypican-1. J. Biol. Chem. 276 29141-7 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Seiradake, E et al. (2009) Structure and functional relevance of the Slit2 homodimerization domain. EMBO Rep. 10 736-41 PubMed GONUTS page
↑ Niclou, SP et al. (2000) Slit2 is a repellent for retinal ganglion cell axons. J. Neurosci. 20 4962-74 PubMed GONUTS page
↑ Itoh, A et al. (1998) Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain Res. Mol. Brain Res. 62 175-86 PubMed GONUTS page
↑ Wu, JY et al. (2001) The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410 948-52 PubMed GONUTS page
↑ Grieshammer, U et al. (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev. Cell 6 709-17 PubMed GONUTS page
↑ ^23.0 ^23.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19056867-1] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:16439689-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Liu, D et al. (2006) Neuronal chemorepellent Slit2 inhibits vascular smooth muscle cell migration by suppressing small GTPase Rac1 activation. Circ. Res. 98 480-9 PubMed GONUTS page

[PMID:18829537-3] 3.0 ^3.1 ^3.2 Marlow, R et al. (2008) SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium. Cancer Res. 68 7819-27 PubMed GONUTS page

[PMID:10102268-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Brose, K et al. (1999) Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 96 795-806 PubMed GONUTS page

[PMID:10975526-5] Zou, Y et al. (2000) Squeezing axons out of the gray matter: a role for slit and semaphorin proteins from midline and ventral spinal cord. Cell 102 363-75 PubMed GONUTS page

[PMID:19351956-6] Urbich, C et al. (2009) HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood 113 5669-79 PubMed GONUTS page

[PMID:17062560-7] 7.0 ^7.1 ^7.2 Hussain, SA et al. (2006) A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. J. Biol. Chem. 281 39693-8 PubMed GONUTS page

[PMID:19759280-8] 8.0 ^8.1 ^8.2 Tole, S et al. (2009) The axonal repellent, Slit2, inhibits directional migration of circulating neutrophils. J. Leukoc. Biol. 86 1403-15 PubMed GONUTS page

[PMID:18566128-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Dickinson, RE et al. (2008) Novel regulated expression of the SLIT/ROBO pathway in the ovary: possible role during luteolysis in women. Endocrinology 149 5024-34 PubMed GONUTS page

[PMID:10197527-10] 10.0 ^10.1 Nguyen Ba-Charvet, KT et al. (1999) Slit2-Mediated chemorepulsion and collapse of developing forebrain axons. Neuron 22 463-73 PubMed GONUTS page

[PMID:19005219-11] 11.0 ^11.1 ^11.2 ^11.3 Stella, MC et al. (2009) The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis. Mol. Biol. Cell 20 642-57 PubMed GONUTS page

[PMID:11748139-12] 12.0 ^12.1 ^12.2 Patel, K et al. (2001) Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons. Development 128 5031-7 PubMed GONUTS page

[PMID:16840550-13] Lin, L & Isacson, O (2006) Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. Stem Cells 24 2504-13 PubMed GONUTS page

[PMID:18345009-14] 14.0 ^14.1 ^14.2 ^14.3 Jones, CA et al. (2008) Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat. Med. 14 448-53 PubMed GONUTS page

[PMID:15207848-15] 15.0 ^15.1 ^15.2 Liu, Z et al. (2004) Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol. Cell. Neurosci. 26 232-40 PubMed GONUTS page

[PMID:17848514-16] Morlot, C et al. (2007) Structural insights into the Slit-Robo complex. Proc. Natl. Acad. Sci. U.S.A. 104 14923-8 PubMed GONUTS page

[PMID:11375980-17] Ronca, F et al. (2001) Characterization of Slit protein interactions with glypican-1. J. Biol. Chem. 276 29141-7 PubMed GONUTS page

[PMID:19498462-18] 18.0 ^18.1 ^18.2 Seiradake, E et al. (2009) Structure and functional relevance of the Slit2 homodimerization domain. EMBO Rep. 10 736-41 PubMed GONUTS page

[PMID:10864954-19] Niclou, SP et al. (2000) Slit2 is a repellent for retinal ganglion cell axons. J. Neurosci. 20 4962-74 PubMed GONUTS page

[PMID:9813312-20] Itoh, A et al. (1998) Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain Res. Mol. Brain Res. 62 175-86 PubMed GONUTS page

[PMID:11309622-21] Wu, JY et al. (2001) The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors. Nature 410 948-52 PubMed GONUTS page

[PMID:15130495-22] Grieshammer, U et al. (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev. Cell 6 709-17 PubMed GONUTS page

[PMID:21873635-23] 23.0 ^23.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:SLIT2

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