HUMAN:SLIT1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SLIT1 (synonyms: KIAA0813, MEGF4, SLIL1)
Protein Name(s)	Slit homolog 1 protein Slit-1 Multiple epidermal growth factor-like domains protein 4 Multiple EGF-like domains protein 4
External Links
UniProt	O75093
EMBL	AB017167 AB011537 AL442123 AL512424 AL512424 AL442123 CH471066 BC146851 AY029183
CCDS	CCDS7453.1
RefSeq	NP_003052.2
UniGene	Hs.632082
ProteinModelPortal	O75093
SMR	O75093
BioGrid	112472
IntAct	O75093
MINT	MINT-2797238
STRING	9606.ENSP00000266058
PhosphoSite	O75093
MaxQB	O75093
PaxDb	O75093
PRIDE	O75093
Ensembl	ENST00000266058
GeneID	6585
KEGG	hsa:6585
UCSC	uc001kmw.2 uc009xvh.1
CTD	6585
GeneCards	GC10M098747
H-InvDB	HIX0079168 HIX0170440
HGNC	HGNC:11085
HPA	HPA006879
MIM	603742
neXtProt	NX_O75093
PharmGKB	PA35938
eggNOG	COG4886
GeneTree	ENSGT00760000118786
HOGENOM	HOG000116120
HOVERGEN	HBG057959
InParanoid	O75093
KO	K06838
OrthoDB	EOG78WKQW
PhylomeDB	O75093
TreeFam	TF332887
Reactome	REACT_22237
ChiTaRS	SLIT1
GeneWiki	SLIT1
GenomeRNAi	6585
NextBio	25625
PRO	PR:O75093
Proteomes	UP000005640
Bgee	O75093
CleanEx	HS_SLIT1
ExpressionAtlas	O75093
Genevestigator	O75093
GO	GO:0005615 GO:0005509 GO:0048495 GO:0048846 GO:0007411 GO:0033563 GO:0040023 GO:0048853 GO:0008045 GO:0050919 GO:0048843 GO:0051964 GO:0031290 GO:0021510 GO:0022028
Gene3D	2.60.120.200
InterPro	IPR013320 IPR000483 IPR006207 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR003645 IPR009030 IPR001791 IPR001611 IPR025875 IPR003591 IPR000372
Pfam	PF00008 PF12661 PF02210 PF12799 PF13855 PF01463 PF01462
SMART	SM00041 SM00181 SM00179 SM00274 SM00282 SM00369 SM00082 SM00013
SUPFAM	SSF49899 SSF57184
PROSITE	PS01185 PS01225 PS00022 PS01186 PS50026 PS01187 PS50025 PS51450

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0051964	negative regulation of synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q3S2J2	P	Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	PMID:11748139^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048853	forebrain morphogenesis	PMID:9813312^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048846	axon extension involved in axon guidance	PMID:16840550^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048495	Roundabout binding	PMID:15207848^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Y6N7	F	Seeded From UniProt	complete
enables	GO:0048495	Roundabout binding	PMID:15207848^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9HCK4	F	Seeded From UniProt	complete
NOT\|involved_in	GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	PMID:11748139^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:16162649^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	PMID:11748139^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9813312^[2]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:9813312^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0007097	C	Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
enables	GO:0048495	Roundabout binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	F	Seeded From UniProt	complete
involved_in	GO:0033563	dorsal/ventral axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
involved_in	GO:0031290	retinal ganglion cell axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
involved_in	GO:0022029	telencephalon cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
involved_in	GO:0022028	tangential migration from the subventricular zone to the olfactory bulb	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
involved_in	GO:0021772	olfactory bulb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
involved_in	GO:0007097	nuclear migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80TR4 ensembl:ENSMUSP00000025993	C	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001881 InterPro:IPR018097	F	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Patel, K et al. (2001) Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons. Development 128 5031-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Itoh, A et al. (1998) Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain Res. Mol. Brain Res. 62 175-86 PubMed GONUTS page
↑ Lin, L & Isacson, O (2006) Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. Stem Cells 24 2504-13 PubMed GONUTS page
↑ ^4.0 ^4.1 Liu, Z et al. (2004) Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol. Cell. Neurosci. 26 232-40 PubMed GONUTS page
↑ Hammond, R et al. (2005) Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain. Development 132 4483-95 PubMed GONUTS page

[PMID:11748139-1] 1.0 ^1.1 ^1.2 Patel, K et al. (2001) Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons. Development 128 5031-7 PubMed GONUTS page

[PMID:9813312-2] 2.0 ^2.1 ^2.2 Itoh, A et al. (1998) Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Brain Res. Mol. Brain Res. 62 175-86 PubMed GONUTS page

[PMID:16840550-3] Lin, L & Isacson, O (2006) Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. Stem Cells 24 2504-13 PubMed GONUTS page

[PMID:15207848-4] 4.0 ^4.1 Liu, Z et al. (2004) Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding. Mol. Cell. Neurosci. 26 232-40 PubMed GONUTS page

[PMID:16162649-5] Hammond, R et al. (2005) Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain. Development 132 4483-95 PubMed GONUTS page

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HUMAN:SLIT1

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