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HUMAN:SIA4A
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ST3GAL1 (synonyms: SIAT4, SIAT4A) | |
| Protein Name(s) | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Alpha 2,3-ST 1 Beta-galactoside alpha-2,3-sialyltransferase 1 Gal-NAc6S Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase SIATFL ST3Gal I ST3GalI ST3GalA.1 ST3O Sialyltransferase 4A SIAT4-A | |
| External Links | ||
| UniProt | Q11201 | |
| EMBL | L29555 L13972 AF059321 BC018357 | |
| CCDS | CCDS6373.1 | |
| PIR | I54229 | |
| RefSeq | NP_003024.1 NP_775479.1 XP_005251080.1 XP_005251081.1 XP_005251082.1 XP_006716680.1 | |
| UniGene | Hs.374257 | |
| ProteinModelPortal | Q11201 | |
| SMR | Q11201 | |
| BioGrid | 112375 | |
| IntAct | Q11201 | |
| STRING | 9606.ENSP00000318445 | |
| CAZy | GT29 | |
| DMDM | 1705559 | |
| MaxQB | Q11201 | |
| PaxDb | Q11201 | |
| PRIDE | Q11201 | |
| DNASU | 6482 | |
| Ensembl | ENST00000399640 ENST00000521180 ENST00000522652 | |
| GeneID | 6482 | |
| KEGG | hsa:6482 | |
| UCSC | uc003yuk.2 | |
| CTD | 6482 | |
| GeneCards | GC08M134468 | |
| HGNC | HGNC:10862 | |
| HPA | HPA040466 | |
| MIM | 607187 | |
| neXtProt | NX_Q11201 | |
| PharmGKB | PA35764 | |
| eggNOG | NOG249462 | |
| GeneTree | ENSGT00760000119095 | |
| HOGENOM | HOG000126811 | |
| HOVERGEN | HBG054227 | |
| InParanoid | Q11201 | |
| KO | K00780 | |
| OMA | TWFPKQM | |
| OrthoDB | EOG7C8GH8 | |
| PhylomeDB | Q11201 | |
| TreeFam | TF354325 | |
| BioCyc | MetaCyc:HS00250-MONOMER | |
| BRENDA | 2.4.99.4 | |
| Reactome | REACT_115835 REACT_121120 REACT_200874 | |
| UniPathway | UPA00378 | |
| ChiTaRS | ST3GAL1 | |
| GenomeRNAi | 6482 | |
| NextBio | 25179 | |
| PRO | PR:Q11201 | |
| Proteomes | UP000005640 | |
| Bgee | Q11201 | |
| CleanEx | HS_ST3GAL1 | |
| ExpressionAtlas | Q11201 | |
| Genevestigator | Q11201 | |
| GO | GO:0070062 GO:0032580 GO:0000139 GO:0030173 GO:0016020 GO:0003836 GO:0005975 GO:0044267 GO:0006464 GO:0030203 GO:0018146 GO:0042339 GO:0006054 GO:0016266 GO:0043687 GO:0006487 GO:0006468 GO:0097503 GO:0044281 | |
| InterPro | IPR001675 IPR012163 | |
| Pfam | PF00777 | |
| PIRSF | PIRSF005557 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0003836 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
ECO:0000314 |
F |
Figure 3 |
complete | |||||
|
enables |
GO:0003836 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097503 |
sialylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006487 |
protein N-linked glycosylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006054 |
N-acetylneuraminate metabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003836 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003836 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:98304 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54751 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54751 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003836 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54751 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008373 |
sialyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003836 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006464 |
cellular protein modification process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003836 |
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018146 |
keratan sulfate biosynthetic process |
Reactome:R-HSA-2022854 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016266 |
O-glycan processing |
Reactome:R-HSA-977068 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000139 |
Golgi membrane |
Reactome:R-HSA-981497 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016757 |
transferase activity, transferring glycosyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032580 |
Golgi cisterna membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00378 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Jeanneau, C et al. (2004) Structure-function analysis of the human sialyltransferase ST3Gal I: role of n-glycosylation and a novel conserved sialylmotif. J. Biol. Chem. 279 13461-8 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Shang, J et al. (1999) Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver. Eur. J. Biochem. 265 580-8 PubMed GONUTS page
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