HUMAN:SERA

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PHGDH (synonyms: PGDH3)
Protein Name(s)	D-3-phosphoglycerate dehydrogenase 3-PGDH
External Links
UniProt	O43175
EMBL	AF006043 AF171237 CR456795 AK315360 AL589734 AL139251 AL139251 AL589734 CH471122 BC000303 BC001349 BC011262
CCDS	CCDS904.1
RefSeq	NP_006614.2
UniGene	Hs.487296
PDB	2G76
PDBsum	2G76
ProteinModelPortal	O43175
SMR	O43175
BioGrid	117618
IntAct	O43175
MINT	MINT-4999739
STRING	9606.ENSP00000358417
ChEMBL	CHEMBL2311243
PhosphoSite	O43175
MaxQB	O43175
PaxDb	O43175
PeptideAtlas	O43175
PRIDE	O43175
DNASU	26227
Ensembl	ENST00000369409
GeneID	26227
KEGG	hsa:26227
UCSC	uc001ehz.3
CTD	26227
GeneCards	GC01P120202
HGNC	HGNC:8923
HPA	CAB003681 HPA021241 HPA024031
MIM	256520 601815 606879
neXtProt	NX_O43175
Orphanet	79351 2671
PharmGKB	PA33264
eggNOG	COG0111
GeneTree	ENSGT00530000063021
HOGENOM	HOG000136693
HOVERGEN	HBG054241
InParanoid	O43175
KO	K00058
OMA	DNTFAQC
OrthoDB	EOG7JT6WT
PhylomeDB	O43175
TreeFam	TF314548
BioCyc	MetaCyc:HS01776-MONOMER
Reactome	REACT_115789
UniPathway	UPA00135
ChiTaRS	PHGDH
EvolutionaryTrace	O43175
GeneWiki	Phosphoglycerate_dehydrogenase
GenomeRNAi	26227
NextBio	48383
PRO	PR:O43175
Proteomes	UP000005640
Bgee	O43175
CleanEx	HS_PHGDH
ExpressionAtlas	O43175
Genevestigator	O43175
GO	GO:0005829 GO:0070062 GO:0009055 GO:0051287 GO:0004617 GO:0007420 GO:0008652 GO:0034641 GO:0070314 GO:0009448 GO:0021782 GO:0006541 GO:0006544 GO:0006564 GO:0021915 GO:0031175 GO:0010468 GO:0044281 GO:0021510 GO:0019530 GO:0006566
Gene3D	3.30.1330.90 3.40.50.720
InterPro	IPR029009 IPR006139 IPR029753 IPR029752 IPR006140 IPR016040 IPR006236
Pfam	PF00389 PF02826
SUPFAM	SSF143548
TIGRFAMs	TIGR01327
PROSITE	PS00065 PS00670 PS00671

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0070062	extracellular exosome	PMID:23533145^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0006520	cellular amino acid metabolic process	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1355330 PANTHER:PTN000107810 UniProtKB:P9WNX3	P		Seeded From UniProt	complete
enables	GO:0004617	phosphoglycerate dehydrogenase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000107810 RGD:61987 TAIR:locus:505006128 UniProtKB:P9WNX3	F		Seeded From UniProt	complete
involved_in	GO:0022900	electron transport chain	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0009055	P		Seeded From UniProt	complete
enables	GO:0004617	phosphoglycerate dehydrogenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O08651 ensembl:ENSRNOP00000053019	F		Seeded From UniProt	complete
involved_in	GO:0070314	G1 to G0 transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0031175	neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0021782	glial cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0019530	taurine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0009448	gamma-aminobutyric acid metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0006566	threonine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0006563	L-serine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0006544	glycine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
involved_in	GO:0006541	glutamine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61753 ensembl:ENSMUSP00000064755	P		Seeded From UniProt	complete
enables	GO:0004617	phosphoglycerate dehydrogenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006236	F		Seeded From UniProt	complete
involved_in	GO:0006564	L-serine biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006236	P		Seeded From UniProt	complete
enables	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006139	F		Seeded From UniProt	complete
enables	GO:0051287	NAD binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006139 InterPro:IPR006140	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006139 InterPro:IPR006140	P		Seeded From UniProt	complete
enables	GO:0004617	phosphoglycerate dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.95	F		Seeded From UniProt	complete
enables	GO:0030060	L-malate dehydrogenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.1.1.37	F		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	PMID:8758134^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004617	phosphoglycerate dehydrogenase activity	PMID:8758134^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0009055	electron transfer activity	PMID:8758134^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006564	L-serine biosynthetic process	Reactome:R-HSA-977347	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-977348	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
involved_in	GO:0006564	L-serine biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0718	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0008652	cellular amino acid biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0028	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Jaeken, J et al. (1996) 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis. Arch. Dis. Child. 74 542-5 PubMed GONUTS page

[PMID:23533145-1] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19199708-2] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-3] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-4] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8758134-6] 6.0 ^6.1 ^6.2 Jaeken, J et al. (1996) 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis. Arch. Dis. Child. 74 542-5 PubMed GONUTS page

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HUMAN:SERA

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Annotations

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References

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