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HUMAN:SERA
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | PHGDH (synonyms: PGDH3) | |
Protein Name(s) | D-3-phosphoglycerate dehydrogenase
3-PGDH | |
External Links | ||
UniProt | O43175 | |
EMBL | AF006043 AF171237 CR456795 AK315360 AL589734 AL139251 AL139251 AL589734 CH471122 BC000303 BC001349 BC011262 | |
CCDS | CCDS904.1 | |
RefSeq | NP_006614.2 | |
UniGene | Hs.487296 | |
PDB | 2G76 | |
PDBsum | 2G76 | |
ProteinModelPortal | O43175 | |
SMR | O43175 | |
BioGrid | 117618 | |
IntAct | O43175 | |
MINT | MINT-4999739 | |
STRING | 9606.ENSP00000358417 | |
ChEMBL | CHEMBL2311243 | |
PhosphoSite | O43175 | |
MaxQB | O43175 | |
PaxDb | O43175 | |
PeptideAtlas | O43175 | |
PRIDE | O43175 | |
DNASU | 26227 | |
Ensembl | ENST00000369409 | |
GeneID | 26227 | |
KEGG | hsa:26227 | |
UCSC | uc001ehz.3 | |
CTD | 26227 | |
GeneCards | GC01P120202 | |
HGNC | HGNC:8923 | |
HPA | CAB003681 HPA021241 HPA024031 | |
MIM | 256520 601815 606879 | |
neXtProt | NX_O43175 | |
Orphanet | 79351 2671 | |
PharmGKB | PA33264 | |
eggNOG | COG0111 | |
GeneTree | ENSGT00530000063021 | |
HOGENOM | HOG000136693 | |
HOVERGEN | HBG054241 | |
InParanoid | O43175 | |
KO | K00058 | |
OMA | DNTFAQC | |
OrthoDB | EOG7JT6WT | |
PhylomeDB | O43175 | |
TreeFam | TF314548 | |
BioCyc | MetaCyc:HS01776-MONOMER | |
Reactome | REACT_115789 | |
UniPathway | UPA00135 | |
ChiTaRS | PHGDH | |
EvolutionaryTrace | O43175 | |
GeneWiki | Phosphoglycerate_dehydrogenase | |
GenomeRNAi | 26227 | |
NextBio | 48383 | |
PRO | PR:O43175 | |
Proteomes | UP000005640 | |
Bgee | O43175 | |
CleanEx | HS_PHGDH | |
ExpressionAtlas | O43175 | |
Genevestigator | O43175 | |
GO | GO:0005829 GO:0070062 GO:0009055 GO:0051287 GO:0004617 GO:0007420 GO:0008652 GO:0034641 GO:0070314 GO:0009448 GO:0021782 GO:0006541 GO:0006544 GO:0006564 GO:0021915 GO:0031175 GO:0010468 GO:0044281 GO:0021510 GO:0019530 GO:0006566 | |
Gene3D | 3.30.1330.90 3.40.50.720 | |
InterPro | IPR029009 IPR006139 IPR029753 IPR029752 IPR006140 IPR016040 IPR006236 | |
Pfam | PF00389 PF02826 | |
SUPFAM | SSF143548 | |
TIGRFAMs | TIGR01327 | |
PROSITE | PS00065 PS00670 PS00671 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001831) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(CL:0000639) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006520 |
cellular amino acid metabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1355330 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004617 |
phosphoglycerate dehydrogenase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000107810 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0022900 |
electron transport chain |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0009055 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004617 |
phosphoglycerate dehydrogenase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:O08651 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070314 |
G1 to G0 transition |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031175 |
neuron projection development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0022008 |
neurogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021915 |
neural tube development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021782 |
glial cell development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021510 |
spinal cord development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019530 |
taurine metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010468 |
regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009448 |
gamma-aminobutyric acid metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006566 |
threonine metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006563 |
L-serine metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006544 |
glycine metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006541 |
glutamine metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q61753 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004617 |
phosphoglycerate dehydrogenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006564 |
L-serine biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016616 |
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0051287 |
NAD binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004617 |
phosphoglycerate dehydrogenase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0030060 |
L-malate dehydrogenase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007420 |
brain development |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004617 |
phosphoglycerate dehydrogenase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0009055 |
electron transfer activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006564 |
L-serine biosynthetic process |
Reactome:R-HSA-977347 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-977348 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006564 |
L-serine biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008652 |
cellular amino acid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
- ↑ 5.0 5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Jaeken, J et al. (1996) 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis. Arch. Dis. Child. 74 542-5 PubMed GONUTS page
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