GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:SERA

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PHGDH (synonyms: PGDH3)
Protein Name(s) D-3-phosphoglycerate dehydrogenase

3-PGDH

External Links
UniProt O43175
EMBL AF006043
AF171237
CR456795
AK315360
AL589734
AL139251
AL139251
AL589734
CH471122
BC000303
BC001349
BC011262
CCDS CCDS904.1
RefSeq NP_006614.2
UniGene Hs.487296
PDB 2G76
PDBsum 2G76
ProteinModelPortal O43175
SMR O43175
BioGrid 117618
IntAct O43175
MINT MINT-4999739
STRING 9606.ENSP00000358417
ChEMBL CHEMBL2311243
PhosphoSite O43175
MaxQB O43175
PaxDb O43175
PeptideAtlas O43175
PRIDE O43175
DNASU 26227
Ensembl ENST00000369409
GeneID 26227
KEGG hsa:26227
UCSC uc001ehz.3
CTD 26227
GeneCards GC01P120202
HGNC HGNC:8923
HPA CAB003681
HPA021241
HPA024031
MIM 256520
601815
606879
neXtProt NX_O43175
Orphanet 79351
2671
PharmGKB PA33264
eggNOG COG0111
GeneTree ENSGT00530000063021
HOGENOM HOG000136693
HOVERGEN HBG054241
InParanoid O43175
KO K00058
OMA DNTFAQC
OrthoDB EOG7JT6WT
PhylomeDB O43175
TreeFam TF314548
BioCyc MetaCyc:HS01776-MONOMER
Reactome REACT_115789
UniPathway UPA00135
ChiTaRS PHGDH
EvolutionaryTrace O43175
GeneWiki Phosphoglycerate_dehydrogenase
GenomeRNAi 26227
NextBio 48383
PRO PR:O43175
Proteomes UP000005640
Bgee O43175
CleanEx HS_PHGDH
ExpressionAtlas O43175
Genevestigator O43175
GO GO:0005829
GO:0070062
GO:0009055
GO:0051287
GO:0004617
GO:0007420
GO:0008652
GO:0034641
GO:0070314
GO:0009448
GO:0021782
GO:0006541
GO:0006544
GO:0006564
GO:0021915
GO:0031175
GO:0010468
GO:0044281
GO:0021510
GO:0019530
GO:0006566
Gene3D 3.30.1330.90
3.40.50.720
InterPro IPR029009
IPR006139
IPR029753
IPR029752
IPR006140
IPR016040
IPR006236
Pfam PF00389
PF02826
SUPFAM SSF143548
TIGRFAMs TIGR01327
PROSITE PS00065
PS00670
PS00671

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:23533145[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

involved_in

GO:0006520

cellular amino acid metabolic process

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1355330
PANTHER:PTN000107810
UniProtKB:P9WNX3

P

Seeded From UniProt

complete

enables

GO:0004617

phosphoglycerate dehydrogenase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000107810
RGD:61987
TAIR:locus:505006128
UniProtKB:P9WNX3

F

Seeded From UniProt

complete

involved_in

GO:0022900

electron transport chain

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0009055

P

Seeded From UniProt

complete

enables

GO:0004617

phosphoglycerate dehydrogenase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O08651
ensembl:ENSRNOP00000053019

F

Seeded From UniProt

complete

involved_in

GO:0070314

G1 to G0 transition

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0031175

neuron projection development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0022008

neurogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0021915

neural tube development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0021782

glial cell development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0021510

spinal cord development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0019530

taurine metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0009448

gamma-aminobutyric acid metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0006566

threonine metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0006563

L-serine metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0006544

glycine metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

involved_in

GO:0006541

glutamine metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61753
ensembl:ENSMUSP00000064755

P

Seeded From UniProt

complete

enables

GO:0004617

phosphoglycerate dehydrogenase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006236

F

Seeded From UniProt

complete

involved_in

GO:0006564

L-serine biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006236

P

Seeded From UniProt

complete

enables

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006139

F

Seeded From UniProt

complete

enables

GO:0051287

NAD binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006139
InterPro:IPR006140

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR006139
InterPro:IPR006140

P

Seeded From UniProt

complete

enables

GO:0004617

phosphoglycerate dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.95

F

Seeded From UniProt

complete

enables

GO:0030060

L-malate dehydrogenase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.1.1.37

F

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:8758134[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004617

phosphoglycerate dehydrogenase activity

PMID:8758134[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0009055

electron transfer activity

PMID:8758134[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006564

L-serine biosynthetic process

Reactome:R-HSA-977347

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-977348

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0006564

L-serine biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0718

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

involved_in

GO:0008652

cellular amino acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0028

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  2. Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  3. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  5. 5.0 5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. 6.0 6.1 6.2 Jaeken, J et al. (1996) 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis. Arch. Dis. Child. 74 542-5 PubMed GONUTS page