HUMAN:SEM3C

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SEMA3C (synonyms: SEMAE)
Protein Name(s)	Semaphorin-3C Semaphorin-E Sema E
External Links
UniProt	Q99985
EMBL	AB000220 AK299322 AC004880 AC004972 AC073850 AC093683 BC030690
CCDS	CCDS5596.1
RefSeq	NP_006370.1
UniGene	Hs.269109
ProteinModelPortal	Q99985
SMR	Q99985
STRING	9606.ENSP00000265361
PhosphoSite	Q99985
DMDM	8134685
MaxQB	Q99985
PaxDb	Q99985
PeptideAtlas	Q99985
PRIDE	Q99985
DNASU	10512
Ensembl	ENST00000265361 ENST00000419255
GeneID	10512
KEGG	hsa:10512
UCSC	uc003uhj.3
CTD	10512
GeneCards	GC07M080371
HGNC	HGNC:10725
HPA	HPA042418
MIM	602645
neXtProt	NX_Q99985
PharmGKB	PA35647
eggNOG	NOG247865
GeneTree	ENSGT00760000118854
HOVERGEN	HBG055071
InParanoid	Q99985
KO	K06840
OrthoDB	EOG7034G7
PhylomeDB	Q99985
TreeFam	TF352628
ChiTaRS	SEMA3C
GeneWiki	SEMA3C
GenomeRNAi	10512
NextBio	35474419
PRO	PR:Q99985
Proteomes	UP000005640
Bgee	Q99985
CleanEx	HS_SEMA3C
ExpressionAtlas	Q99985
Genevestigator	Q99985
GO	GO:0005615 GO:0070062 GO:0016020 GO:0004872 GO:0007411 GO:0001974 GO:0003215 GO:0060666 GO:0006955 GO:0060174 GO:0001755 GO:0021915 GO:0003151 GO:0009791 GO:0003350 GO:0042493 GO:0001756
Gene3D	2.130.10.10 2.60.40.10
InterPro	IPR007110 IPR013783 IPR013098 IPR003599 IPR016201 IPR001627 IPR027231 IPR015943
PANTHER	PTHR11036
Pfam	PF07679 PF01403
SMART	SM00409 SM00423 SM00630
SUPFAM	SSF101912 SSF103575
PROSITE	PS50835 PS51004

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1905312	positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62181	P	part_of:(GO:0071526)	Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62181	P	part_of:(GO:0071526)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62181	P		Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107556 MGI:MGI:107557 MGI:MGI:107558 MGI:MGI:107560 MGI:MGI:109252 MGI:MGI:1203727 MGI:MGI:1340034 PANTHER:PTN000867340 UniProtKB:Q92854	P		Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107558 MGI:MGI:1096347 PANTHER:PTN000744245	P		Seeded From UniProt	complete
involved_in	GO:0048843	negative regulation of axon extension involved in axon guidance	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107558 MGI:MGI:1096347 PANTHER:PTN000867340 RGD:1308650	P		Seeded From UniProt	complete
enables	GO:0045499	chemorepellent activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107558 MGI:MGI:1096347 PANTHER:PTN000867340 UniProtKB:Q13275	F		Seeded From UniProt	complete
enables	GO:0038191	neuropilin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107558 PANTHER:PTN000867406 UniProtKB:A0A1D5PZ68 UniProtKB:O42236 UniProtKB:O42237 UniProtKB:Q90607 UniProtKB:Q90663	F		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109244 PANTHER:PTN000867340 UniProtKB:Q92854	P		Seeded From UniProt	complete
enables	GO:0030215	semaphorin receptor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107556 MGI:MGI:107557 MGI:MGI:107558 MGI:MGI:109244 MGI:MGI:1202889 MGI:MGI:1203727 MGI:MGI:1338032 MGI:MGI:1340034 MGI:MGI:2387661 PANTHER:PTN000867340 UniProtKB:Q92854 WB:WBGene00003111 WB:WBGene00004889	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1203727 PANTHER:PTN000112372 UniProtKB:Q92854	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107557 MGI:MGI:109244 PANTHER:PTN000744245 UniProtKB:A0A1D5PZ68 UniProtKB:O42236 UniProtKB:O42237 UniProtKB:Q90607 UniProtKB:Q90663	C		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107557 MGI:MGI:1096347 PANTHER:PTN000867340 ZFIN:ZDB-GENE-050513-4	P		Seeded From UniProt	complete
involved_in	GO:1905312	positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0140074	cardiac endothelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0060174	limb bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
enables	GO:0030215	semaphorin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	F		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	C		Seeded From UniProt	complete
involved_in	GO:0003350	pulmonary myocardium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0003215	cardiac right ventricle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0001755	neural crest cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62181 ensembl:ENSMUSP00000030568	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:9405678^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:9168980^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yamada, T et al. (1997) Identification of semaphorin E as a non-MDR drug resistance gene of human cancers. Proc. Natl. Acad. Sci. U.S.A. 94 14713-8 PubMed GONUTS page
↑ Mangasser-Stephan, K et al. (1997) Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display. Biochem. Biophys. Res. Commun. 234 153-6 PubMed GONUTS page

[PMID:23533145-1] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 ^2.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9405678-3] Yamada, T et al. (1997) Identification of semaphorin E as a non-MDR drug resistance gene of human cancers. Proc. Natl. Acad. Sci. U.S.A. 94 14713-8 PubMed GONUTS page

[PMID:9168980-4] Mangasser-Stephan, K et al. (1997) Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display. Biochem. Biophys. Res. Commun. 234 153-6 PubMed GONUTS page

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HUMAN:SEM3C

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