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HUMAN:SCYL2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SCYL2 (synonyms: CVAK104, KIAA1360) | |
| Protein Name(s) | SCY1-like protein 2
Coated vesicle-associated kinase of 104 kDa | |
| External Links | ||
| UniProt | Q6P3W7 | |
| EMBL | AK001597 AK024274 AK027551 AK292980 CH471054 BC012387 BC063798 AB037781 | |
| CCDS | CCDS9076.1 | |
| RefSeq | NP_060458.3 XP_005269075.1 | |
| UniGene | Hs.506481 | |
| ProteinModelPortal | Q6P3W7 | |
| SMR | Q6P3W7 | |
| BioGrid | 120810 | |
| IntAct | Q6P3W7 | |
| MINT | MINT-1181355 | |
| STRING | 9606.ENSP00000354061 | |
| PhosphoSite | Q6P3W7 | |
| DMDM | 74762350 | |
| MaxQB | Q6P3W7 | |
| PaxDb | Q6P3W7 | |
| PRIDE | Q6P3W7 | |
| DNASU | 55681 | |
| Ensembl | ENST00000360820 | |
| GeneID | 55681 | |
| KEGG | hsa:55681 | |
| UCSC | uc001thm.1 | |
| CTD | 55681 | |
| GeneCards | GC12P100661 | |
| HGNC | HGNC:19286 | |
| HPA | HPA021050 | |
| neXtProt | NX_Q6P3W7 | |
| PharmGKB | PA134887807 | |
| eggNOG | NOG251280 | |
| GeneTree | ENSGT00500000044907 | |
| HOVERGEN | HBG055627 | |
| InParanoid | Q6P3W7 | |
| KO | K17541 | |
| OMA | QFYKGLP | |
| PhylomeDB | Q6P3W7 | |
| TreeFam | TF314178 | |
| SignaLink | Q6P3W7 | |
| ChiTaRS | SCYL2 | |
| GeneWiki | SCYL2 | |
| GenomeRNAi | 55681 | |
| NextBio | 60474 | |
| PRO | PR:Q6P3W7 | |
| Proteomes | UP000005640 | |
| Bgee | Q6P3W7 | |
| CleanEx | HS_SCYL2 | |
| ExpressionAtlas | Q6P3W7 | |
| Genevestigator | Q6P3W7 | |
| GO | GO:0030136 GO:0010008 GO:0005794 GO:0048471 GO:0005524 GO:0004672 GO:0005102 GO:0008333 GO:0090090 GO:2000370 GO:0002092 GO:2000286 | |
| Gene3D | 1.25.10.10 | |
| InterPro | IPR011989 IPR016024 IPR011009 IPR000719 | |
| Pfam | PF00069 | |
| SUPFAM | SSF48371 SSF56112 | |
| PROSITE | PS50011 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
19643732 |
ECO:0000021 |
|
F |
Fig 1C. Immunoprecipitation analysis: positive signal in anti-CVAK104 precipitates, but not with control rabbit IgG. |
Missing: reference | |||
| GO:0002092 |
positive regulation of receptor internalization |
19643732 |
ECO:0000314 |
P |
Fig 2B. When cotransfected with CVAK104, dotlike pattern of Fzd5-GFP is seen throughout in the cell; in control it is localised at edge. |
Missing: reference | ||||
| GO:0090090 |
negative regulation of canonical Wnt receptor signaling pathway |
19643732 |
ECO:0000314 |
P |
Fig 6. Results implicate CVAK104 in negative regulation of Wnt signalling pathway, e.g. knockdown of CVAK104 resulted in increase in activated beta-catenin. |
Missing: reference | ||||
| GO:0005102 |
receptor binding |
19643732 |
ECO:0000021 |
|
F |
Fig 4A. Only Fzd5-GFP co-precipitated with FLAG-CVAK104. |
Missing: reference | |||
|
involved_in |
GO:2000370 |
positive regulation of clathrin-dependent endocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000286 |
receptor internalization involved in canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008333 |
endosome to lysosome transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002092 |
positive regulation of receptor internalization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005794 |
Golgi apparatus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031410 |
cytoplasmic vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005768 |
endosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0010008 |
endosome membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0030136 |
clathrin-coated vesicle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
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