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HUMAN:SCTM1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SECTM1 (synonyms: K12)
Protein Name(s) Secreted and transmembrane protein 1

Protein K-12

External Links
UniProt Q8WVN6
EMBL U77643
AK312980
CH471099
BC017716
CCDS CCDS11808.1
RefSeq NP_002995.1
XP_005256449.1
UniGene Hs.558009
ProteinModelPortal Q8WVN6
BioGrid 112298
IntAct Q8WVN6
PhosphoSite Q8WVN6
DMDM 25009245
MaxQB Q8WVN6
PaxDb Q8WVN6
PeptideAtlas Q8WVN6
PRIDE Q8WVN6
DNASU 6398
Ensembl ENST00000269389
GeneID 6398
KEGG hsa:6398
UCSC uc002keo.3
CTD 6398
GeneCards GC17M080278
HGNC HGNC:10707
HPA HPA051214
MIM 602602
neXtProt NX_Q8WVN6
PharmGKB PA35630
eggNOG NOG38953
GeneTree ENSGT00530000064499
HOGENOM HOG000231222
HOVERGEN HBG061092
InParanoid Q8WVN6
OrthoDB EOG71RXKJ
PhylomeDB Q8WVN6
TreeFam TF336992
ChiTaRS SECTM1
GeneWiki SECTM1
GenomeRNAi 6398
NextBio 24856
PRO PR:Q8WVN6
Proteomes UP000005640
Bgee Q8WVN6
CleanEx HS_SECTM1
ExpressionAtlas Q8WVN6
Genevestigator Q8WVN6
GO GO:0005615
GO:0070062
GO:0005794
GO:0016021
GO:0005886
GO:0005125
GO:0004871
GO:0006955
GO:0007498
GO:0043123
GO:0007165

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016021

integral to membrane

PMID:9480746[1]

ECO:0000314

C

Fig.3C western blot detected K12 protein in the insoluble pellet fraction after treatment with sodium carbonate(pH 11.5)

complete
CACAO 4589

part_of

GO:0016021

integral component of membrane

PMID:9480746[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19056867[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:12761501[4]

ECO:0007001

high throughput mutant phenotypic evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000387964
UniProtKB:Q8WVN6

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033231

F

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033231

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:9480746[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007498

mesoderm development

PMID:9480746[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:9480746[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:9480746[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:9480746[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

PMID:9480746[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Slentz-Kesler, KA et al. (1998) Identification and characterization of K12 (SECTM1), a novel human gene that encodes a Golgi-associated protein with transmembrane and secreted isoforms. Genomics 47 327-40 PubMed GONUTS page
  2. Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  4. Matsuda, A et al. (2003) Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Oncogene 22 3307-18 PubMed GONUTS page
  5. Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page