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HUMAN:SCNNG

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SCNN1G
Protein Name(s) Amiloride-sensitive sodium channel subunit gamma

Epithelial Na(+) channel subunit gamma ENaCG Gamma-ENaC Gamma-NaCH Nonvoltage-gated sodium channel 1 subunit gamma SCNEG

External Links
UniProt P51170
EMBL X87160
L36592
AF356502
AF356493
AF356494
AF356495
AF356496
AF356497
AF356498
AF356499
AF356500
AF356501
BC059391
BC069652
U48936
U53836
U53837
U53841
U53844
U53845
U53846
U53847
U53850
U53852
U35630
CCDS CCDS10608.1
PIR I38204
I64847
RefSeq NP_001030.2
UniGene Hs.371727
ProteinModelPortal P51170
SMR P51170
BioGrid 112244
IntAct P51170
MINT MINT-198604
ChEMBL CHEMBL2107836
DrugBank DB00594
DB00384
TCDB 1.A.6.1.1
PhosphoSite P51170
DMDM 108885072
PaxDb P51170
PRIDE P51170
Ensembl ENST00000300061
GeneID 6340
KEGG hsa:6340
UCSC uc002dlm.1
CTD 6340
GeneCards GC16P023101
HGNC HGNC:10602
MIM 177200
600761
613071
neXtProt NX_P51170
Orphanet 171876
60033
526
PharmGKB PA307
eggNOG NOG294559
GeneTree ENSGT00760000119120
HOVERGEN HBG058435
InParanoid P51170
KO K04827
OMA NWMYCYY
OrthoDB EOG7T1R9N
PhylomeDB P51170
TreeFam TF330663
Reactome REACT_160189
GeneWiki SCNN1G
GenomeRNAi 6340
NextBio 24620
PRO PR:P51170
Proteomes UP000005640
Bgee P51170
ExpressionAtlas P51170
Genevestigator P51170
GO GO:0016324
GO:0009897
GO:0070062
GO:0005887
GO:0005886
GO:0034706
GO:0015280
GO:0005272
GO:0050699
GO:0007588
GO:0034220
GO:0050891
GO:0050896
GO:0050909
GO:0055078
GO:0035725
GO:0006814
GO:0055085
InterPro IPR004724
IPR001873
IPR020903
PANTHER PTHR11690
Pfam PF00858
PRINTS PR01078
TIGRFAMs TIGR00859
PROSITE PS01206

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0005216

ion channel activity

PMID:22864553[1]

ECO:0000315

F

"ENaC stimulation by Cat-S was associated with the appearance of a γENaC cleavage fragment at the plasma membrane indicating proteolytic channel activation." Figures 7 and 8 demonstrate this association.

complete
CACAO 5364

enables

GO:0005216

ion channel activity

PMID:22864553[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:15326289[2]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

enables

GO:0050699

WW domain binding

PMID:10642508[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P46934

F

Seeded From UniProt

complete

involved_in

GO:0055078

sodium ion homeostasis

PMID:24124190[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050891

multicellular organismal water homeostasis

PMID:24124190[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035725

sodium ion transmembrane transport

PMID:24124190[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034706

sodium channel complex

PMID:24124190[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

contributes_to

GO:0015280

ligand-gated sodium channel activity

PMID:24124190[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:24124190[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0050699

WW domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WU39
ensembl:ENSMUSP00000000221

F

Seeded From UniProt

complete

part_of

GO:0034706

sodium channel complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WU39
ensembl:ENSMUSP00000000221

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WU39
ensembl:ENSMUSP00000000221

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WU39
ensembl:ENSMUSP00000000221

C

Seeded From UniProt

complete

enables

GO:0015280

ligand-gated sodium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WU39
ensembl:ENSMUSP00000000221

F

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WU39
ensembl:ENSMUSP00000000221

C

Seeded From UniProt

complete

involved_in

GO:0006814

sodium ion transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WU39
ensembl:ENSMUSP00000000221

P

Seeded From UniProt

complete

enables

GO:0005272

sodium channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WU39
ensembl:ENSMUSP00000000221

F

Seeded From UniProt

complete

enables

GO:0005272

sodium channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001873
InterPro:IPR020903

F

Seeded From UniProt

complete

involved_in

GO:0006814

sodium ion transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001873
InterPro:IPR004724
InterPro:IPR020903

P

Seeded From UniProt

complete

enables

GO:0015280

ligand-gated sodium channel activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004724

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001873
InterPro:IPR020903

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004724

C

Seeded From UniProt

complete

enables

GO:0015280

ligand-gated sodium channel activity

PMID:8640238[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007588

excretion

PMID:8640238[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006814

sodium ion transport

PMID:8521520[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:8640238[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005272

sodium channel activity

PMID:8521520[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

Reactome:R-HSA-983712

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-2682349
Reactome:R-HSA-2672334

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0050909

sensory perception of taste

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0919

P

Seeded From UniProt

complete

involved_in

GO:0006814

sodium ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0739

P

Seeded From UniProt

complete

involved_in

GO:0006811

ion transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0406

P

Seeded From UniProt

complete

involved_in

GO:0050896

response to stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

enables

GO:0005272

sodium channel activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0894

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0015

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Haerteis, S et al. (2012) Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S. Pflugers Arch. 464 353-65 PubMed GONUTS page
  2. ↑ Pisitkun, T et al. (2004) Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. U.S.A. 101 13368-73 PubMed GONUTS page
  3. ↑ Farr, TJ et al. (2000) Human Nedd4 interacts with the human epithelial Na+ channel: WW3 but not WW1 binds to Na+-channel subunits. Biochem. J. 345 Pt 3 503-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Hobbs, CA et al. (2013) Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Am. J. Physiol. Lung Cell Mol. Physiol. 305 L990-L1001 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Strautnieks, SS et al. (1996) A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families. Nat. Genet. 13 248-50 PubMed GONUTS page
  6. ↑ 6.0 6.1 Snyder, PM et al. (1995) Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel. Cell 83 969-78 PubMed GONUTS page
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