HUMAN:SCN4B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SCN4B
Protein Name(s)	Sodium channel subunit beta-4
External Links
UniProt	Q8IWT1
EMBL	AY149967 AP002800 BC035017
CCDS	CCDS44744.1 CCDS8389.1
RefSeq	NP_001135820.1 NP_001135821.1 NP_777594.1
UniGene	Hs.65239
PDB	4MZ2 4MZ3
PDBsum	4MZ2 4MZ3
ProteinModelPortal	Q8IWT1
SMR	Q8IWT1
BioGrid	112235
STRING	9606.ENSP00000322460
DrugBank	DB00313 DB00909
TCDB	8.A.17.2.2
PhosphoSite	Q8IWT1
DMDM	57012701
PaxDb	Q8IWT1
PRIDE	Q8IWT1
Ensembl	ENST00000324727 ENST00000529878
GeneID	6330
KEGG	hsa:6330
UCSC	uc001pse.3
CTD	6330
GeneCards	GC11M118004
GeneReviews	SCN4B
HGNC	HGNC:10592
HPA	HPA017293
MIM	608256 611819
neXtProt	NX_Q8IWT1
Orphanet	334 101016
PharmGKB	PA35007
eggNOG	NOG46712
GeneTree	ENSGT00640000091161
HOGENOM	HOG000048715
HOVERGEN	HBG056581
InParanoid	Q8IWT1
KO	K04848
OMA	REKKKEC
OrthoDB	EOG7WT42T
PhylomeDB	Q8IWT1
TreeFam	TF331728
Reactome	REACT_22266
ChiTaRS	SCN4B
GeneWiki	SCN4B
GenomeRNAi	6330
NextBio	24574
PMAP-CutDB	Q8IWT1
PRO	PR:Q8IWT1
Proteomes	UP000005640
Bgee	Q8IWT1
CleanEx	HS_SCN4B
ExpressionAtlas	Q8IWT1
Genevestigator	Q8IWT1
GO	GO:0014704 GO:0031226 GO:0001518 GO:0044325 GO:0017080 GO:0005248 GO:0086006 GO:0086067 GO:0086002 GO:0060048 GO:0086012 GO:0010765 GO:0086091 GO:2000649 GO:0060307 GO:0035725 GO:0006814
Gene3D	2.60.40.10
InterPro	IPR007110 IPR013783 IPR003599 IPR013106 IPR000920
PANTHER	PTHR13869
Pfam	PF07686
SMART	SM00409
PROSITE	PS50835

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:17592081^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:17592081^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086016	AV node cell action potential	PMID:17592081^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0086012	membrane depolarization during cardiac muscle cell action potential	PMID:17592081^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	PMID:17592081^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0086002	cardiac muscle cell action potential involved in contraction	PMID:17592081^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	PMID:17592081^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:17592081^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:17592081^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14524	F	Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	PMID:20226894^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:17592081^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q7M729	C	Seeded From UniProt	complete
involved_in	GO:0010765	positive regulation of sodium ion transport	PMID:17592081^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:17592081^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:24297919^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	PMID:24297919^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:24297919^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	PMID:12930796^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	PMID:12930796^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:24297919^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:12930796^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M729 ensembl:ENSMUSP00000062507	P	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M729 ensembl:ENSMUSP00000062507	C	Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M729 ensembl:ENSMUSP00000062507	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q7M730 ensembl:ENSRNOP00000033284	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000920	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P	Seeded From UniProt	complete
enables	GO:0005272	sodium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0894	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0739	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P	Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Medeiros-Domingo, A et al. (2007) SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome. Circulation 116 134-42 PubMed GONUTS page
↑ Tan, BH et al. (2010) Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm 7 771-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gilchrist, J et al. (2013) Crystallographic insights into sodium-channel modulation by the β4 subunit. Proc. Natl. Acad. Sci. U.S.A. 110 E5016-24 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Yu, FH et al. (2003) Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J. Neurosci. 23 7577-85 PubMed GONUTS page

[PMID:17592081-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Medeiros-Domingo, A et al. (2007) SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome. Circulation 116 134-42 PubMed GONUTS page

[PMID:20226894-2] Tan, BH et al. (2010) Sudden infant death syndrome-associated mutations in the sodium channel beta subunits. Heart Rhythm 7 771-8 PubMed GONUTS page

[PMID:24297919-3] 3.0 ^3.1 ^3.2 ^3.3 Gilchrist, J et al. (2013) Crystallographic insights into sodium-channel modulation by the β4 subunit. Proc. Natl. Acad. Sci. U.S.A. 110 E5016-24 PubMed GONUTS page

[PMID:12930796-4] 4.0 ^4.1 ^4.2 Yu, FH et al. (2003) Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J. Neurosci. 23 7577-85 PubMed GONUTS page

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HUMAN:SCN4B

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