GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:SCN2B
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SCN2B | |
| Protein Name(s) | Sodium channel subunit beta-2 | |
| External Links | ||
| UniProt | O60939 | |
| EMBL | AF007783 AF049498 AF049497 AF049496 AF107028 U87555 AY358945 BC036793 | |
| CCDS | CCDS8390.1 | |
| RefSeq | NP_004579.1 | |
| UniGene | Hs.129783 | |
| ProteinModelPortal | O60939 | |
| SMR | O60939 | |
| BioGrid | 112232 | |
| STRING | 9606.ENSP00000278947 | |
| DrugBank | DB00313 DB00909 | |
| TCDB | 8.A.17.2.1 | |
| PhosphoSite | O60939 | |
| PaxDb | O60939 | |
| PeptideAtlas | O60939 | |
| PRIDE | O60939 | |
| DNASU | 6327 | |
| Ensembl | ENST00000278947 | |
| GeneID | 6327 | |
| KEGG | hsa:6327 | |
| UCSC | uc001psf.2 | |
| CTD | 6327 | |
| GeneCards | GC11M118033 | |
| HGNC | HGNC:10589 | |
| HPA | HPA012585 | |
| MIM | 601327 615378 | |
| neXtProt | NX_O60939 | |
| Orphanet | 334 | |
| PharmGKB | PA303 | |
| eggNOG | NOG26453 | |
| HOGENOM | HOG000118120 | |
| HOVERGEN | HBG003443 | |
| InParanoid | O60939 | |
| KO | K04846 | |
| OMA | CSNCSEE | |
| OrthoDB | EOG7NSB42 | |
| PhylomeDB | O60939 | |
| TreeFam | TF331728 | |
| Reactome | REACT_22266 | |
| ChiTaRS | SCN2B | |
| GeneWiki | SCN2B | |
| GenomeRNAi | 6327 | |
| NextBio | 24558 | |
| PMAP-CutDB | O60939 | |
| PRO | PR:O60939 | |
| Proteomes | UP000005640 | |
| Bgee | O60939 | |
| CleanEx | HS_SCN2B | |
| ExpressionAtlas | O60939 | |
| Genevestigator | O60939 | |
| GO | GO:0001518 GO:0017080 GO:0086006 GO:0086002 GO:0060048 GO:0086012 GO:0007399 GO:0060371 GO:0086091 GO:2000649 GO:0046684 GO:0035725 GO:0007268 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR007110 IPR013783 IPR003599 IPR013106 IPR000920 IPR029873 | |
| PANTHER | PTHR13869 PTHR13869:SF3 | |
| Pfam | PF07686 | |
| PRINTS | PR00213 | |
| SMART | SM00409 | |
| PROSITE | PS50835 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0086012 |
membrane depolarization during cardiac muscle cell action potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000649 |
regulation of sodium ion transmembrane transporter activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:Q14524) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0086091 |
regulation of heart rate by cardiac conduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0086006 |
voltage-gated sodium channel activity involved in cardiac muscle cell action potential |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0086002 |
cardiac muscle cell action potential involved in contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060371 |
regulation of atrial cardiac muscle cell membrane depolarization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060048 |
cardiac muscle contraction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035725 |
sodium ion transmembrane transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017080 |
sodium channel regulator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:Q14524) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0001518 |
voltage-gated sodium channel complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046684 |
response to pyrethroid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54900 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54900 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005248 |
voltage-gated sodium channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P54900 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0001518 |
voltage-gated sodium channel complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017080 |
sodium channel regulator activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007268 |
chemical synaptic transmission |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0001518 |
voltage-gated sodium channel complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005272 |
sodium channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034765 |
regulation of ion transmembrane transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005244 |
voltage-gated ion channel activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006814 |
sodium ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006811 |
ion transport |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Watanabe, H et al. (2009) Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol 2 268-75 PubMed GONUTS page
- ↑ 2.0 2.1 Eubanks, J et al. (1997) Structure and chromosomal localization of the beta2 subunit of the human brain sodium channel. Neuroreport 8 2775-9 PubMed GONUTS page
c
m
p
r
- GO:2000649 ! regulation of sodium ion transmembrane transporter activity
- GO:0034765 ! regulation of monoatomic ion transmembrane transport
- GO:0086091 ! regulation of heart rate by cardiac conduction
- GO:0060371 ! regulation of atrial cardiac muscle cell membrane depolarization
- GO:0046684 ! response to pyrethroid
s
