HUMAN:SCN1B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SCN1B
Protein Name(s)	Sodium channel subunit beta-1
External Links
UniProt	Q07699
EMBL	L10338 L16242 U12193 U12189 U12190 U12191 U12192 AY391842 AK313279 DQ677665 BT019923 AC020907 BC067122
CCDS	CCDS12441.1 CCDS46047.1
PIR	A55734
RefSeq	NP_001028.1 NP_950238.1
UniGene	Hs.436646
ProteinModelPortal	Q07699
SMR	Q07699
BioGrid	112229
STRING	9606.ENSP00000396915
DrugBank	DB00313 DB00909
PhosphoSite	Q07699
DMDM	1705868
PaxDb	Q07699
PRIDE	Q07699
DNASU	6324
Ensembl	ENST00000262631 ENST00000415950
GeneID	6324
KEGG	hsa:6324
UCSC	uc002nxo.2 uc002nxp.3
CTD	6324
GeneCards	GC19P035521
GeneReviews	SCN1B
HGNC	HGNC:10586
MIM	600235 604233 612838 615377
neXtProt	NX_Q07699
Orphanet	130 33069 334 871 36387
PharmGKB	PA302
eggNOG	NOG45207
GeneTree	ENSGT00390000018560
HOGENOM	HOG000276881
HOVERGEN	HBG056582
InParanoid	Q07699
KO	K04845
OMA	ISCKKRS
OrthoDB	EOG7M3J19
PhylomeDB	Q07699
TreeFam	TF332097
Reactome	REACT_22266
GeneWiki	SCN1B
GenomeRNAi	6324
NextBio	24542
PMAP-CutDB	Q07699
PRO	PR:Q07699
Proteomes	UP000005640
Bgee	Q07699
CleanEx	HS_SCN1B
ExpressionAtlas	Q07699
Genevestigator	Q07699
GO	GO:0005576 GO:0014704 GO:0033268 GO:0030315 GO:0001518 GO:0019871 GO:0017080 GO:0005248 GO:0086006 GO:0086062 GO:0007411 GO:0061337 GO:0086002 GO:0060048 GO:0007155 GO:0021966 GO:0040011 GO:0051899 GO:0086012 GO:0086047 GO:0019227 GO:0010976 GO:0010765 GO:0060371 GO:0086091 GO:2000649 GO:0060307 GO:0046684 GO:0035725 GO:0007268
Gene3D	2.60.40.10
InterPro	IPR013783 IPR013151 IPR027098
PANTHER	PTHR10546
Pfam	PF00047

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0017080	sodium channel regulator activity	PMID:19710327^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:19710327^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:8125980^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:8125980^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:30190309^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:30190309^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:19808477^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q14524)	Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:19808477^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential	PMID:18464934^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential	PMID:18464934^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0086012	membrane depolarization during cardiac muscle cell action potential	PMID:17884088^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	P		Seeded From UniProt	complete
enables	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	PMID:19808477^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0086002	cardiac muscle cell action potential involved in contraction	PMID:19808477^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061337	cardiac conduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	P		Seeded From UniProt	complete
involved_in	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	PMID:19808477^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	PMID:22247482^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	PMID:17884088^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	P		Seeded From UniProt	complete
involved_in	GO:0060048	cardiac muscle contraction	PMID:19808477^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	PMID:21051419^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	P		Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	PMID:18464934^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	PMID:19808477^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	PMID:21051419^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0033268	node of Ranvier	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	C		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	C	part_of:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0021966	corticospinal neuron axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	P		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	PMID:17884088^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	F		Seeded From UniProt	complete
involved_in	GO:0019227	neuronal action potential propagation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	P		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:18464934^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q14524)	Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:19808477^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q14524)	Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	C	part_of:(CL:0000746)	Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	P	occurs_in:(CL:0001031)	Seeded From UniProt	complete
involved_in	GO:0010765	positive regulation of sodium ion transport	PMID:19808477^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P97952	P		Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	PMID:19808477^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:21051419^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:19808477^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000649	regulation of sodium ion transmembrane transporter activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002237886 UniProtKB:Q07699 UniProtKB:Q9NY72	P		Seeded From UniProt	complete
involved_in	GO:0086091	regulation of heart rate by cardiac conduction	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000057590 UniProtKB:Q07699 UniProtKB:Q9NY72	P		Seeded From UniProt	complete
involved_in	GO:0086002	cardiac muscle cell action potential involved in contraction	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000057590 UniProtKB:Q07699 UniProtKB:Q9NY72	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1918882 PANTHER:PTN002237886 UniProtKB:Q9NY72	F		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98247 PANTHER:PTN002237886	F		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002237886 RGD:3631 UniProtKB:Q07699 UniProtKB:Q9NY72	C		Seeded From UniProt	complete
involved_in	GO:0086012	membrane depolarization during cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	P		Seeded From UniProt	complete
enables	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	F		Seeded From UniProt	complete
involved_in	GO:0061337	cardiac conduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	P		Seeded From UniProt	complete
involved_in	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	P		Seeded From UniProt	complete
involved_in	GO:0040011	locomotion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	P		Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	P		Seeded From UniProt	complete
part_of	GO:0034706	sodium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	C		Seeded From UniProt	complete
part_of	GO:0033268	node of Ranvier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	C		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	C		Seeded From UniProt	complete
involved_in	GO:0021966	corticospinal neuron axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	P		Seeded From UniProt	complete
enables	GO:0019871	sodium channel inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	F		Seeded From UniProt	complete
involved_in	GO:0019227	neuronal action potential propagation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	P		Seeded From UniProt	complete
part_of	GO:0014704	intercalated disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	C		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P97952 ensembl:ENSMUSP00000096148	P		Seeded From UniProt	complete
involved_in	GO:1905150	regulation of voltage-gated sodium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00954 ensembl:ENSRNOP00000074323	P		Seeded From UniProt	complete
involved_in	GO:0046684	response to pyrethroid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00954 ensembl:ENSRNOP00000074323	P		Seeded From UniProt	complete
part_of	GO:0033268	node of Ranvier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00954 ensembl:ENSRNOP00000074323	C		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00954 ensembl:ENSRNOP00000074323	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00954 ensembl:ENSRNOP00000074323	C		Seeded From UniProt	complete
involved_in	GO:0002028	regulation of sodium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00954 ensembl:ENSRNOP00000074323	P		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00954 ensembl:ENSRNOP00000074323	C		Seeded From UniProt	complete
part_of	GO:0001518	voltage-gated sodium channel complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027098	C		Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027098	P		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027098	F		Seeded From UniProt	complete
enables	GO:0017080	sodium channel regulator activity	PMID:14622265^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
NOT\|enables	GO:0017080	sodium channel regulator activity	PMID:14622265^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035725	sodium ion transmembrane transport	PMID:14622265^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005248	voltage-gated sodium channel activity	PMID:14622265^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0061337	cardiac conduction	Reactome:R-HSA-5576892	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-5576895	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034765	regulation of ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	P		Seeded From UniProt	complete
involved_in	GO:0006814	sodium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0739	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966 UniProtKB-SubCell:SL-0280	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0005244	voltage-gated ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0851	F		Seeded From UniProt	complete
enables	GO:0005272	sodium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0894	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Patino, GA et al. (2009) A functional null mutation of SCN1B in a patient with Dravet syndrome. J. Neurosci. 29 10764-78 PubMed GONUTS page
↑ ^2.0 ^2.1 Makita, N et al. (1994) Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene. J. Biol. Chem. 269 7571-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Pan, X et al. (2018) Structure of the human voltage-gated sodium channel Na1.4 in complex with β1. Science 362 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 Watanabe, H et al. (2009) Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol 2 268-75 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Watanabe, H et al. (2008) Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J. Clin. Invest. 118 2260-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lopez-Santiago, LF et al. (2007) Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J. Mol. Cell. Cardiol. 43 636-47 PubMed GONUTS page
↑ Makita, N et al. (2012) A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Circ Arrhythm Electrophysiol 5 163-72 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Olesen, MS et al. (2011) Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc. Res. 89 786-93 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Qin, N et al. (2003) Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit. Eur. J. Biochem. 270 4762-70 PubMed GONUTS page

[PMID:19710327-1] 1.0 ^1.1 Patino, GA et al. (2009) A functional null mutation of SCN1B in a patient with Dravet syndrome. J. Neurosci. 29 10764-78 PubMed GONUTS page

[PMID:8125980-2] 2.0 ^2.1 Makita, N et al. (1994) Voltage-gated Na+ channel beta 1 subunit mRNA expressed in adult human skeletal muscle, heart, and brain is encoded by a single gene. J. Biol. Chem. 269 7571-8 PubMed GONUTS page

[PMID:30190309-3] 3.0 ^3.1 Pan, X et al. (2018) Structure of the human voltage-gated sodium channel Na1.4 in complex with β1. Science 362 PubMed GONUTS page

[PMID:19808477-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 Watanabe, H et al. (2009) Mutations in sodium channel β1- and β2-subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol 2 268-75 PubMed GONUTS page

[PMID:18464934-5] 5.0 ^5.1 ^5.2 ^5.3 Watanabe, H et al. (2008) Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans. J. Clin. Invest. 118 2260-8 PubMed GONUTS page

[PMID:17884088-6] 6.0 ^6.1 ^6.2 Lopez-Santiago, LF et al. (2007) Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J. Mol. Cell. Cardiol. 43 636-47 PubMed GONUTS page

[PMID:22247482-7] Makita, N et al. (2012) A connexin40 mutation associated with a malignant variant of progressive familial heart block type I. Circ Arrhythm Electrophysiol 5 163-72 PubMed GONUTS page

[PMID:21051419-8] 8.0 ^8.1 ^8.2 Olesen, MS et al. (2011) Mutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc. Res. 89 786-93 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14622265-10] 10.0 ^10.1 ^10.2 ^10.3 Qin, N et al. (2003) Molecular cloning and functional expression of the human sodium channel beta1B subunit, a novel splicing variant of the beta1 subunit. Eur. J. Biochem. 270 4762-70 PubMed GONUTS page

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HUMAN:SCN1B

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