HUMAN:S26A5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SLC26A5 (synonyms: PRES)
Protein Name(s)	Prestin Solute carrier family 26 member 5
External Links
UniProt	P58743
EMBL	AF523354 AY256823 AY256824 AY256825 AY289134 AC004668 AC005064 AC093701 BC100833
CCDS	CCDS43629.1 CCDS43630.1 CCDS55150.1 CCDS5732.1 CCDS5733.1
RefSeq	NP_001161434.1 NP_945350.1 NP_996766.1 NP_996767.1 NP_996768.1
UniGene	Hs.585146
ProteinModelPortal	P58743
SMR	P58743
STRING	9606.ENSP00000304783
TCDB	2.A.53.2.19
PhosphoSite	P58743
DMDM	20139418
PaxDb	P58743
PRIDE	P58743
Ensembl	ENST00000306312 ENST00000339444 ENST00000356767 ENST00000393723 ENST00000393730 ENST00000393735 ENST00000432958
GeneID	375611
KEGG	hsa:375611
UCSC	uc003vbt.2 uc003vbu.2 uc003vbv.2 uc003vbx.3 uc003vbz.3
CTD	375611
GeneCards	GC07M102993
HGNC	HGNC:9359
MIM	604943 613865
neXtProt	NX_P58743
Orphanet	90636
PharmGKB	PA33731
eggNOG	COG0659
GeneTree	ENSGT00760000119026
HOGENOM	HOG000006546
HOVERGEN	HBG000639
InParanoid	P58743
KO	K14703
OrthoDB	EOG76T9QT
PhylomeDB	P58743
TreeFam	TF313784
GeneWiki	Prestin
GenomeRNAi	375611
NextBio	100545
PRO	PR:P58743
Proteomes	UP000005640
Bgee	P58743
CleanEx	HS_SLC26A5
ExpressionAtlas	P58743
Genevestigator	P58743
GO	GO:0016323 GO:0016021 GO:0016328 GO:0008271 GO:0008360 GO:0042391 GO:0007605
Gene3D	3.30.750.24
InterPro	IPR030282 IPR018045 IPR002645 IPR001902 IPR030402 IPR011547
PANTHER	PTHR11814 PTHR11814:SF32
Pfam	PF01740 PF13792 PF00916
SUPFAM	SSF52091
TIGRFAMs	TIGR00815
PROSITE	PS01130 PS50801

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0007605	sensory perception of sound	PMID:12719379^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019531	oxalate transmembrane transporter activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036770 MGI:MGI:2159728 MGI:MGI:2385894 PANTHER:PTN000929177 UniProtKB:Q8TE54 UniProtKB:Q96RN1 UniProtKB:Q9BXS9 WB:WBGene00010788	F	Seeded From UniProt	complete
enables	GO:0015301	anion:anion antiporter activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107181 MGI:MGI:2159728 MGI:MGI:2385894 MGI:MGI:2444594 PANTHER:PTN000212031 UniProtKB:Q7LBE3 UniProtKB:Q9BXS9	F	Seeded From UniProt	complete
enables	GO:0015116	sulfate transmembrane transporter activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036770 MGI:MGI:2159728 MGI:MGI:2385894 PANTHER:PTN001370913 RGD:620136 RGD:620622 SGD:S000000498 SGD:S000004082 TAIR:locus:2029396 TAIR:locus:2029496 TAIR:locus:2138561 TAIR:locus:2184158 TAIR:locus:3437527 UniProtKB:A8J6J0 UniProtKB:P50443 UniProtKB:Q5B9Q0 UniProtKB:Q8TE54 UniProtKB:Q96RN1 UniProtKB:Q9BXS9 WB:WBGene00010788 WB:WBGene00017464	F	Seeded From UniProt	complete
enables	GO:0015108	chloride transmembrane transporter activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107181 MGI:MGI:2159728 MGI:MGI:2385894 PANTHER:PTN000929177 RGD:3293 UniProtKB:Q9BXS9 WB:WBGene00010788	F	Seeded From UniProt	complete
enables	GO:0015106	bicarbonate transmembrane transporter activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0036770 MGI:MGI:107181 MGI:MGI:2159728 MGI:MGI:2384791 MGI:MGI:2444594 PANTHER:PTN000929177 UniProtKB:Q9BXS9	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2159728 PANTHER:PTN000212031 UniProtKB:P50443 UniProtKB:P96878	C	Seeded From UniProt	complete
involved_in	GO:0015701	bicarbonate transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015106	P	Seeded From UniProt	complete
involved_in	GO:0019532	oxalate transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019531	P	Seeded From UniProt	complete
involved_in	GO:1902358	sulfate transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008271	P	Seeded From UniProt	complete
involved_in	GO:1902358	sulfate transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015116	P	Seeded From UniProt	complete
involved_in	GO:1902358	sulfate transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015116	P	Seeded From UniProt	complete
involved_in	GO:2000147	positive regulation of cell motility	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:1902476	chloride transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:1902074	response to salt	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0098656	anion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0097066	response to thyroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0090102	cochlea development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0045793	positive regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	F	Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0035864	response to potassium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0034766	negative regulation of ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	C	Seeded From UniProt	complete
involved_in	GO:0015755	fructose transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0010996	response to auditory stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0009751	response to salicylic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	C	Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9EPH0 ensembl:ENSRNOP00000015733	P	Seeded From UniProt	complete
involved_in	GO:0042391	regulation of membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH7 ensembl:ENSMUSP00000030878	P	Seeded From UniProt	complete
enables	GO:0030507	spectrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH7 ensembl:ENSMUSP00000030878	F	Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH7 ensembl:ENSMUSP00000030878	C	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH7 ensembl:ENSMUSP00000030878	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q99NH7 ensembl:ENSMUSP00000030878	C	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030282	P	Seeded From UniProt	complete
enables	GO:0008271	secondary active sulfate transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001902 InterPro:IPR018045	F	Seeded From UniProt	complete
involved_in	GO:0008272	sulfate transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001902 InterPro:IPR011547 InterPro:IPR018045	P	Seeded From UniProt	complete
enables	GO:0015116	sulfate transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011547	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001902	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011547 InterPro:IPR030282	C	Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001902	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1009	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0133	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Liu, XZ et al. (2003) Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum. Mol. Genet. 12 1155-62 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12719379-1] Liu, XZ et al. (2003) Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum. Mol. Genet. 12 1155-62 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:S26A5

Contents

Annotations

Notes

References

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