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HUMAN:S26A5

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) SLC26A5 (synonyms: PRES)
Protein Name(s) Prestin

Solute carrier family 26 member 5

External Links
UniProt P58743
EMBL AF523354
AY256823
AY256824
AY256825
AY289134
AC004668
AC005064
AC093701
BC100833
CCDS CCDS43629.1
CCDS43630.1
CCDS55150.1
CCDS5732.1
CCDS5733.1
RefSeq NP_001161434.1
NP_945350.1
NP_996766.1
NP_996767.1
NP_996768.1
UniGene Hs.585146
ProteinModelPortal P58743
SMR P58743
STRING 9606.ENSP00000304783
TCDB 2.A.53.2.19
PhosphoSite P58743
DMDM 20139418
PaxDb P58743
PRIDE P58743
Ensembl ENST00000306312
ENST00000339444
ENST00000356767
ENST00000393723
ENST00000393730
ENST00000393735
ENST00000432958
GeneID 375611
KEGG hsa:375611
UCSC uc003vbt.2
uc003vbu.2
uc003vbv.2
uc003vbx.3
uc003vbz.3
CTD 375611
GeneCards GC07M102993
HGNC HGNC:9359
MIM 604943
613865
neXtProt NX_P58743
Orphanet 90636
PharmGKB PA33731
eggNOG COG0659
GeneTree ENSGT00760000119026
HOGENOM HOG000006546
HOVERGEN HBG000639
InParanoid P58743
KO K14703
OrthoDB EOG76T9QT
PhylomeDB P58743
TreeFam TF313784
GeneWiki Prestin
GenomeRNAi 375611
NextBio 100545
PRO PR:P58743
Proteomes UP000005640
Bgee P58743
CleanEx HS_SLC26A5
ExpressionAtlas P58743
Genevestigator P58743
GO GO:0016323
GO:0016021
GO:0016328
GO:0008271
GO:0008360
GO:0042391
GO:0007605
Gene3D 3.30.750.24
InterPro IPR030282
IPR018045
IPR002645
IPR001902
IPR030402
IPR011547
PANTHER PTHR11814
PTHR11814:SF32
Pfam PF01740
PF13792
PF00916
SUPFAM SSF52091
TIGRFAMs TIGR00815
PROSITE PS01130
PS50801

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0007605

sensory perception of sound

PMID:12719379[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019531

oxalate transmembrane transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036770
MGI:MGI:2159728
MGI:MGI:2385894
PANTHER:PTN000929177
UniProtKB:Q8TE54
UniProtKB:Q96RN1
UniProtKB:Q9BXS9
WB:WBGene00010788

F

Seeded From UniProt

complete

enables

GO:0015301

anion:anion antiporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107181
MGI:MGI:2159728
MGI:MGI:2385894
MGI:MGI:2444594
PANTHER:PTN000212031
UniProtKB:Q7LBE3
UniProtKB:Q9BXS9

F

Seeded From UniProt

complete

enables

GO:0015116

sulfate transmembrane transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036770
MGI:MGI:2159728
MGI:MGI:2385894
PANTHER:PTN001370913
RGD:620136
RGD:620622
SGD:S000000498
SGD:S000004082
TAIR:locus:2029396
TAIR:locus:2029496
TAIR:locus:2138561
TAIR:locus:2184158
TAIR:locus:3437527
UniProtKB:A8J6J0
UniProtKB:P50443
UniProtKB:Q5B9Q0
UniProtKB:Q8TE54
UniProtKB:Q96RN1
UniProtKB:Q9BXS9
WB:WBGene00010788
WB:WBGene00017464

F

Seeded From UniProt

complete

enables

GO:0015108

chloride transmembrane transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107181
MGI:MGI:2159728
MGI:MGI:2385894
PANTHER:PTN000929177
RGD:3293
UniProtKB:Q9BXS9
WB:WBGene00010788

F

Seeded From UniProt

complete

enables

GO:0015106

bicarbonate transmembrane transporter activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0036770
MGI:MGI:107181
MGI:MGI:2159728
MGI:MGI:2384791
MGI:MGI:2444594
PANTHER:PTN000929177
UniProtKB:Q9BXS9

F

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2159728
PANTHER:PTN000212031
UniProtKB:P50443
UniProtKB:P96878

C

Seeded From UniProt

complete

involved_in

GO:0015701

bicarbonate transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015106

P

Seeded From UniProt

complete

involved_in

GO:0019532

oxalate transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0019531

P

Seeded From UniProt

complete

involved_in

GO:1902358

sulfate transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008271

P

Seeded From UniProt

complete

involved_in

GO:1902358

sulfate transmembrane transport

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0015116

P

Seeded From UniProt

complete

involved_in

GO:1902358

sulfate transmembrane transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015116

P

Seeded From UniProt

complete

involved_in

GO:2000147

positive regulation of cell motility

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:1902476

chloride transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:1902074

response to salt

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0098656

anion transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0097066

response to thyroid hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0090102

cochlea development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0051262

protein tetramerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0045793

positive regulation of cell size

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

F

Seeded From UniProt

complete

involved_in

GO:0042493

response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0035864

response to potassium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0034766

negative regulation of ion transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0034220

ion transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

part_of

GO:0016328

lateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

C

Seeded From UniProt

complete

involved_in

GO:0015755

fructose transmembrane transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0010996

response to auditory stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0009751

response to salicylic acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

C

Seeded From UniProt

complete

involved_in

GO:0002931

response to ischemia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9EPH0
ensembl:ENSRNOP00000015733

P

Seeded From UniProt

complete

involved_in

GO:0042391

regulation of membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99NH7
ensembl:ENSMUSP00000030878

P

Seeded From UniProt

complete

enables

GO:0030507

spectrin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99NH7
ensembl:ENSMUSP00000030878

F

Seeded From UniProt

complete

part_of

GO:0016328

lateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99NH7
ensembl:ENSMUSP00000030878

C

Seeded From UniProt

complete

part_of

GO:0016323

basolateral plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99NH7
ensembl:ENSMUSP00000030878

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q99NH7
ensembl:ENSMUSP00000030878

C

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030282

P

Seeded From UniProt

complete

enables

GO:0008271

secondary active sulfate transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001902
InterPro:IPR018045

F

Seeded From UniProt

complete

involved_in

GO:0008272

sulfate transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001902
InterPro:IPR011547
InterPro:IPR018045

P

Seeded From UniProt

complete

enables

GO:0015116

sulfate transmembrane transporter activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011547

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001902

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011547
InterPro:IPR030282

C

Seeded From UniProt

complete

involved_in

GO:0055085

transmembrane transport

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001902

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007605

sensory perception of sound

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1009

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0008360

regulation of cell shape

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0133

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Liu, XZ et al. (2003) Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum. Mol. Genet. 12 1155-62 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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