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HUMAN:RIR1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | RRM1 (synonyms: RR1) | |
Protein Name(s) | Ribonucleoside-diphosphate reductase large subunit
Ribonucleoside-diphosphate reductase subunit M1 Ribonucleotide reductase large subunit | |
External Links | ||
UniProt | P23921 | |
EMBL | X59543 X59617 AF107045 BC006498 L10342 | |
CCDS | CCDS7750.1 | |
PIR | S16680 | |
RefSeq | NP_001024.1 NP_001304993.1 NP_001304994.1 | |
UniGene | Hs.445705 | |
PDB | 2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y | |
PDBsum | 2WGH 3HNC 3HND 3HNE 3HNF 4X3V 5D1Y | |
ProteinModelPortal | P23921 | |
SMR | P23921 | |
BioGrid | 112154 | |
DIP | DIP-24233N | |
IntAct | P23921 | |
MINT | MINT-1406473 | |
STRING | 9606.ENSP00000300738 | |
BindingDB | P23921 | |
ChEMBL | CHEMBL2095215 | |
DrugBank | DB00242 DB00631 DB01073 DB00441 DB01005 | |
GuidetoPHARMACOLOGY | 2630 | |
iPTMnet | P23921 | |
PhosphoSite | P23921 | |
SwissPalm | P23921 | |
BioMuta | RRM1 | |
DMDM | 132608 | |
EPD | P23921 | |
MaxQB | P23921 | |
PaxDb | P23921 | |
PeptideAtlas | P23921 | |
PRIDE | P23921 | |
DNASU | 6240 | |
Ensembl | ENST00000300738 | |
GeneID | 6240 | |
KEGG | hsa:6240 | |
UCSC | uc001lyw.5 | |
CTD | 6240 | |
GeneCards | RRM1 | |
HGNC | HGNC:10451 | |
HPA | CAB022093 HPA057265 | |
MIM | 180410 | |
neXtProt | NX_P23921 | |
PharmGKB | PA298 | |
eggNOG | KOG1112 COG0209 | |
GeneTree | ENSGT00390000001372 | |
HOGENOM | HOG000057035 | |
HOVERGEN | HBG003447 | |
InParanoid | P23921 | |
KO | K10807 | |
OMA | YELLWQM | |
OrthoDB | EOG7BGHK2 | |
PhylomeDB | P23921 | |
TreeFam | TF300578 | |
BioCyc | MetaCyc:HS09541-MONOMER | |
BRENDA | 1.17.4.1 | |
Reactome | R-HSA-499943 | |
UniPathway | UPA00326 | |
ChiTaRS | RRM1 | |
EvolutionaryTrace | P23921 | |
GeneWiki | RRM1 | |
GenomeRNAi | 6240 | |
NextBio | 24233 | |
PRO | PR:P23921 | |
Proteomes | UP000005640 | |
Bgee | P23921 | |
CleanEx | HS_RRM1 | |
ExpressionAtlas | P23921 | |
Genevisible | P23921 | |
GO | GO:0042995 GO:0005737 GO:0005829 GO:0070062 GO:0043025 GO:0005635 GO:0005654 GO:0005971 GO:0005524 GO:0004748 GO:0021846 GO:0009263 GO:0006260 GO:0008584 GO:0000278 GO:0015949 GO:0055086 GO:0051290 GO:0006206 GO:0010212 GO:0060041 GO:0044281 | |
InterPro | IPR005144 IPR013346 IPR000788 IPR013509 IPR008926 | |
Pfam | PF03477 PF02867 PF00317 | |
PRINTS | PR01183 | |
SUPFAM | SSF48168 | |
TIGRFAMs | TIGR02506 | |
PROSITE | PS51161 PS00089 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0061731 |
ribonucleoside-diphosphate reductase activity |
ECO:0000315 |
F |
Figure 3e shows the activity of wild-type ribonucleotide reductase relative to two mutant types which was determined using [3H]-CDP and [14C]-ADP reduction assays. ATP binds to the complex and activates it through an allosteric mechanism. This allows the ribonucleotide-diphosphate reductase complex to catalyze the formation of deoxyribonucleotides from ribonucleotides. The D16R mutant protein was not able to be activated by ATP at the allosteric site, and therefore had 45% reduced reductase activity (conversion of ADP to dADP). In the H2E mutant, the reductase activity relative to the wild-type was reduced by 44%. |
complete | |||||
Contributes to |
GO:0061731 |
ribonucleoside-diphosphate reductase activity |
ECO:0000255 |
F |
Fairman et al modeled different hexamer formations based on the crystal structures of two subunits of the ribonucleoside-diphosphate reductase complex and used Phaser (PMID:19461840[2]) to model the hexamer holocomplex (see figure 4). |
Missing: with/from | ||||
involved_in |
GO:0009263 |
deoxyribonucleotide biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009263 |
deoxyribonucleotide biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10660 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005971 |
ribonucleoside-diphosphate reductase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10660 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
EcoGene:EG10660 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0097718 |
disordered domain specific binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07742 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051290 |
protein heterotetramerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07742 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07742 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0017076 |
purine nucleotide binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07742 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009263 |
deoxyribonucleotide biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07742 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005971 |
ribonucleoside-diphosphate reductase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07742 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P07742 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060041 |
retina development in camera-type eye |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0042995 |
cell projection |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0021846 |
cell proliferation in forebrain |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010212 |
response to ionizing radiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008584 |
male gonad development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006206 |
pyrimidine nucleobase metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0000278 |
mitotic cell cycle |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5U2Q5 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006260 |
DNA replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0004748 |
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0015949 |
nucleobase-containing small molecule interconversion |
Reactome:R-HSA-499943 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8866405 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0003824 |
catalytic activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008152 |
metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006260 |
DNA replication |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniProtKB-KW:KW-0235 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Fairman, JW et al. (2011) Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat. Struct. Mol. Biol. 18 316-22 PubMed GONUTS page
- ↑ McCoy, AJ et al. (2007) Phaser crystallographic software. J Appl Crystallogr 40 658-674 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
- ↑ Wang, J et al. (2007) Enhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases. Proc. Natl. Acad. Sci. U.S.A. 104 14324-9 PubMed GONUTS page
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- GO:0010212 ! response to ionizing radiation
- GO:0060041 ! retina development in camera-type eye
- GO:0005971 ! ribonucleoside-diphosphate reductase complex
- GO:0004748 ! ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
- GO:0061731 ! ribonucleoside-diphosphate reductase activity