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HUMAN:RHG18
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ARHGAP18 (ECO:0000312 with HGNC:HGNC:21035) | |
| Protein Name(s) | Rho GTPase-activating protein 18
MacGAP (ECO:0000303 with PMID:21865595[1]) Rho-type GTPase-activating protein 18 | |
| External Links | ||
| UniProt | Q8N392 | |
| EMBL | AL834511 AL450310 CH471051 CH471051 BC017223 BC039611 BC062417 BC101708 BC107416 BC111940 AB053293 | |
| CCDS | CCDS34535.1 | |
| PIR | G59432 | |
| RefSeq | NP_277050.2 | |
| UniGene | Hs.486458 | |
| ProteinModelPortal | Q8N392 | |
| SMR | Q8N392 | |
| BioGrid | 125050 | |
| IntAct | Q8N392 | |
| STRING | 9606.ENSP00000275189 | |
| iPTMnet | Q8N392 | |
| PhosphoSitePlus | Q8N392 | |
| SwissPalm | Q8N392 | |
| BioMuta | ARHGAP18 | |
| DMDM | 296452981 | |
| EPD | Q8N392 | |
| MaxQB | Q8N392 | |
| PaxDb | Q8N392 | |
| PeptideAtlas | Q8N392 | |
| PRIDE | Q8N392 | |
| Ensembl | ENST00000368149 | |
| GeneID | 93663 | |
| KEGG | hsa:93663 | |
| UCSC | uc003qbr.4 | |
| CTD | 93663 | |
| DisGeNET | 93663 | |
| EuPathDB | HostDB:ENSG00000146376.10 | |
| GeneCards | ARHGAP18 | |
| H-InvDB | HIX0006211 | |
| HGNC | HGNC:21035 | |
| HPA | HPA031595 | |
| MIM | 613351 | |
| neXtProt | NX_Q8N392 | |
| OpenTargets | ENSG00000146376 | |
| PharmGKB | PA134884487 | |
| eggNOG | KOG2200 ENOG410XQ10 | |
| GeneTree | ENSGT00760000119123 | |
| HOGENOM | HOG000015106 | |
| HOVERGEN | HBG072023 | |
| InParanoid | Q8N392 | |
| KO | K20639 | |
| OMA | TANTMHL | |
| OrthoDB | EOG091G03X0 | |
| PhylomeDB | Q8N392 | |
| TreeFam | TF314044 | |
| Reactome | [www.reactome.org/content/detail/R-HSA-194840 R-HSA-194840] | |
| ChiTaRS | ARHGAP18 | |
| GenomeRNAi | 93663 | |
| PRO | PR:Q8N392 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000146376 | |
| CleanEx | HS_ARHGAP18 | |
| Genevisible | Q8N392 | |
| GO | GO:0005737 GO:0005829 GO:0016607 GO:0005886 GO:0045296 GO:0005096 GO:0032956 GO:0030833 GO:2000145 GO:0008360 GO:0051056 GO:0007264 | |
| Gene3D | 1.10.555.10 | |
| InterPro | IPR008936 IPR000198 | |
| Pfam | PF00620 | |
| SMART | SM00324 | |
| SUPFAM | SSF48350 | |
| PROSITE | PS50238 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005881 |
cytoplasmic microtubule |
ECO:0000314 |
C |
Homo sapiens, ARHGAP18 (RhoGTPase activating protein 18) Figures 1E and 1F show that ARHGAP18 is localized in individual puncta along microtubule filaments. |
complete | |||||
| GO:0001726 |
ruffle |
ECO:0000314 |
C |
Homo sapiens, ARHGAP18 (RhoGTPase activating protein 18) Figures 1A show that ARHGAP18 localizes to the peripheral membrane ruffles in endothelial cells. |
complete | |||||
|
enables |
GO:0045296 |
cadherin binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030833 |
regulation of actin filament polymerization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032956 |
regulation of actin cytoskeleton organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000145 |
regulation of cell motility |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008360 |
regulation of cell shape |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007264 |
small GTPase mediated signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000384138 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032956 |
regulation of actin cytoskeleton organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001029630 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030833 |
regulation of actin filament polymerization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001029630 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000384138 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0039994 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016607 |
nuclear speck |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005096 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8K0Q5 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051056 |
regulation of small GTPase mediated signal transduction |
Reactome:R-HSA-194840 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-194922 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Maeda, M et al. (2011) ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility. Mol. Biol. Cell 22 3840-52 PubMed GONUTS page
- ↑ 2.0 2.1 Lovelace, MD et al. (2017) The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells. Mol. Biol. Cell 28 1066-1078 PubMed GONUTS page
- ↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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