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HUMAN:RGS16
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | RGS16 (synonyms: RGSR) | |
| Protein Name(s) | Regulator of G-protein signaling 16
RGS16 A28-RGS14P Retinal-specific RGS RGS-r hRGS-r Retinally abundant regulator of G-protein signaling | |
| External Links | ||
| UniProt | O15492 | |
| EMBL | U70426 U94829 AF009356 AF493937 BT006638 AK311880 AL353778 CH471067 BC006243 | |
| CCDS | CCDS1348.1 | |
| RefSeq | NP_002919.3 | |
| UniGene | Hs.413297 | |
| PDB | 2BT2 2IK8 | |
| PDBsum | 2BT2 2IK8 | |
| ProteinModelPortal | O15492 | |
| SMR | O15492 | |
| BioGrid | 111936 | |
| DIP | DIP-59094N | |
| IntAct | O15492 | |
| STRING | 9606.ENSP00000356529 | |
| BindingDB | O15492 | |
| PhosphoSite | O15492 | |
| PaxDb | O15492 | |
| PRIDE | O15492 | |
| DNASU | 6004 | |
| Ensembl | ENST00000367558 | |
| GeneID | 6004 | |
| KEGG | hsa:6004 | |
| UCSC | uc001gpl.4 | |
| CTD | 6004 | |
| GeneCards | GC01M182567 | |
| H-InvDB | HIX0001402 | |
| HGNC | HGNC:9997 | |
| HPA | HPA053250 HPA055824 | |
| MIM | 602514 | |
| neXtProt | NX_O15492 | |
| PharmGKB | PA34367 | |
| eggNOG | NOG269229 | |
| GeneTree | ENSGT00760000118903 | |
| HOGENOM | HOG000233512 | |
| HOVERGEN | HBG013233 | |
| InParanoid | O15492 | |
| KO | K16449 | |
| OMA | SKHSKEG | |
| OrthoDB | EOG7VHSZ5 | |
| PhylomeDB | O15492 | |
| TreeFam | TF315837 | |
| EvolutionaryTrace | O15492 | |
| GeneWiki | RGS16 | |
| GenomeRNAi | 6004 | |
| NextBio | 23419 | |
| PRO | PR:O15492 | |
| Proteomes | UP000005640 | |
| Bgee | O15492 | |
| CleanEx | HS_RGS16 | |
| Genevestigator | O15492 | |
| GO | GO:0005737 GO:0005886 GO:0005516 GO:0005096 GO:0043547 GO:0008277 GO:0038032 GO:0007601 | |
| Gene3D | 1.10.196.10 | |
| InterPro | IPR016137 IPR024066 | |
| Pfam | PF00615 | |
| PRINTS | PR01301 | |
| SMART | SM00315 | |
| SUPFAM | SSF48097 | |
| PROSITE | PS50132 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005737 |
cytoplasm |
ECO:0000314 |
C |
Fig.2 |
complete | |||||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031224 |
intrinsic component of membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043547 |
positive regulation of GTPase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97428 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031224 |
intrinsic component of membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97428 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97428 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97428 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008277 |
regulation of G protein-coupled receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007601 |
visual perception |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005516 |
calmodulin binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
Reactome:R-HSA-388396 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8982026 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
enables |
GO:0003924 |
GTPase activity |
Reactome:R-HSA-8982021 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
|
enables |
GO:0005096 |
GTPase activator activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009968 |
negative regulation of signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Chatterjee, TK & Fisher, RA (2000) Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs. J. Biol. Chem. 275 24013-21 PubMed GONUTS page
- ↑ 2.0 2.1 Soundararajan, M et al. (2008) Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc. Natl. Acad. Sci. U.S.A. 105 6457-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Popov, SG et al. (2000) Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. J. Biol. Chem. 275 18962-8 PubMed GONUTS page
- ↑ Snow, BE et al. (1998) Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene. Gene 206 247-53 PubMed GONUTS page
