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HUMAN:RASN

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NRAS (synonyms: HRAS1)
Protein Name(s) GTPase NRas

Transforming protein N-Ras

External Links
UniProt P01111
EMBL X02751
X00642
X00643
X00644
X00645
L00043
L00040
L00041
L00042
AF493919
AY428630
BC005219
M25898
X53291
X53292
K03211
M10055
X05565
X07440
CCDS CCDS877.1
PIR A90839
I38149
RefSeq NP_002515.1
UniGene Hs.486502
PDB 3CON
PDBsum 3CON
ProteinModelPortal P01111
SMR P01111
BioGrid 110952
DIP DIP-1058N
IntAct P01111
MINT MINT-131535
STRING 9606.ENSP00000358548
BindingDB P01111
ChEMBL CHEMBL2079845
PhosphoSite P01111
DMDM 131883
OGP P01111
MaxQB P01111
PaxDb P01111
PeptideAtlas P01111
PRIDE P01111
DNASU 4893
Ensembl ENST00000369535
GeneID 4893
KEGG hsa:4893
UCSC uc009wgu.3
CTD 4893
GeneCards GC01M115247
GeneReviews NRAS
HGNC HGNC:7989
HPA CAB010157
HPA049830
MIM 137550
162900
164790
249400
607785
613224
614470
neXtProt NX_P01111
Orphanet 86834
626
648
268114
PharmGKB PA31768
eggNOG COG1100
HOGENOM HOG000233973
HOVERGEN HBG009351
InParanoid P01111
KO K07828
OMA RSSYDEI
OrthoDB EOG7QVM41
PhylomeDB P01111
TreeFam TF312796
Reactome REACT_111040
REACT_115852
REACT_115854
REACT_115993
REACT_116005
REACT_118778
REACT_12033
REACT_12065
REACT_121096
REACT_121398
REACT_12579
REACT_12606
REACT_12621
REACT_147814
REACT_163701
REACT_17025
REACT_18334
REACT_2077
REACT_21247
REACT_21374
REACT_228024
REACT_524
REACT_614
REACT_661
REACT_962
SignaLink P01111
ChiTaRS NRAS
EvolutionaryTrace P01111
GeneWiki Neuroblastoma_RAS_viral_oncogene_homolog
GenomeRNAi 4893
NextBio 18835
PRO PR:P01111
Proteomes UP000005640
Bgee P01111
CleanEx HS_NRAS
ExpressionAtlas P01111
Genevestigator P01111
GO GO:0070062
GO:0000139
GO:0016020
GO:0005886
GO:0005525
GO:0032403
GO:0030036
GO:0000186
GO:0007411
GO:0007596
GO:0007173
GO:0060441
GO:0038095
GO:0008543
GO:0006184
GO:0045087
GO:0008286
GO:0050900
GO:0000165
GO:0045596
GO:0043524
GO:0048642
GO:0048011
GO:0008284
GO:0035022
GO:0007265
GO:0048169
GO:0032228
GO:0007264
GO:0051146
GO:0008542
Gene3D 3.40.50.300
InterPro IPR027417
IPR005225
IPR001806
IPR020849
PANTHER PTHR24070
Pfam PF00071
PRINTS PR00449
SMART SM00173
SUPFAM SSF52540
TIGRFAMs TIGR00231
PROSITE PS51421

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0001938

positive regulation of endothelial cell proliferation

PMID:23619365[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0002618)

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21968647[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007265

Ras protein signal transduction

PMID:30712867[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

PMID:30712867[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

PMID:23209302[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003924

GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001806

F

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001806
InterPro:IPR005225
InterPro:IPR020849

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020849

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020849

C

Seeded From UniProt

complete

part_of

GO:0070821

tertiary granule membrane

Reactome:R-HSA-6798747

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007265

Ras protein signal transduction

Reactome:R-HSA-167044

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-8981355
Reactome:R-HSA-8981353
Reactome:R-HSA-8941628
Reactome:R-HSA-8941623
Reactome:R-HSA-8941618
Reactome:R-HSA-8941613
Reactome:R-HSA-8936731
Reactome:R-HSA-8936676
Reactome:R-HSA-8853307
Reactome:R-HSA-8851899
Reactome:R-HSA-8851877
Reactome:R-HSA-8851827
Reactome:R-HSA-6803240
Reactome:R-HSA-6803234
Reactome:R-HSA-6803233
Reactome:R-HSA-6803230
Reactome:R-HSA-6802943
Reactome:R-HSA-6802942
Reactome:R-HSA-6802941
Reactome:R-HSA-6802937
Reactome:R-HSA-6802926
Reactome:R-HSA-6802925
Reactome:R-HSA-6802924
Reactome:R-HSA-6802922
Reactome:R-HSA-6802921
Reactome:R-HSA-6802919
Reactome:R-HSA-6802918
Reactome:R-HSA-6802916
Reactome:R-HSA-6802915
Reactome:R-HSA-6802914
Reactome:R-HSA-6802908
Reactome:R-HSA-6802837
Reactome:R-HSA-6802834
Reactome:R-HSA-6798747
Reactome:R-HSA-5675433
Reactome:R-HSA-5675431
Reactome:R-HSA-5675417
Reactome:R-HSA-5674022
Reactome:R-HSA-5674018
Reactome:R-HSA-5672980
Reactome:R-HSA-5672978
Reactome:R-HSA-5672973
Reactome:R-HSA-5672972
Reactome:R-HSA-5672969
Reactome:R-HSA-5672966
Reactome:R-HSA-5672965
Reactome:R-HSA-5672950
Reactome:R-HSA-5658435
Reactome:R-HSA-5658231
Reactome:R-HSA-5655347
Reactome:R-HSA-5655326
Reactome:R-HSA-5655277
Reactome:R-HSA-5655241
Reactome:R-HSA-5654663
Reactome:R-HSA-5654647
Reactome:R-HSA-5654618
Reactome:R-HSA-5654600
Reactome:R-HSA-5654426
Reactome:R-HSA-5654413
Reactome:R-HSA-5654402
Reactome:R-HSA-5654392
Reactome:R-HSA-5637808
Reactome:R-HSA-5637806
Reactome:R-HSA-5624494
Reactome:R-HSA-5624492
Reactome:R-HSA-5624486
Reactome:R-HSA-5621573
Reactome:R-HSA-5218845
Reactome:R-HSA-392054
Reactome:R-HSA-2424477
Reactome:R-HSA-2179407
Reactome:R-HSA-210977
Reactome:R-HSA-186834
Reactome:R-HSA-177945
Reactome:R-HSA-177938
Reactome:R-HSA-170986
Reactome:R-HSA-1433471
Reactome:R-HSA-1306972
Reactome:R-HSA-1250383
Reactome:R-HSA-1225957
Reactome:R-HSA-1225951
Reactome:R-HSA-1168636

ECO:0000304

author statement supported by traceable reference used in manual assertion


















































































C

Seeded From UniProt

complete

involved_in

GO:0002223

stimulatory C-type lectin receptor signaling pathway

Reactome:R-HSA-5621481

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

Reactome:R-HSA-5673001

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333

C

Seeded From UniProt

complete

enables

GO:0005525

GTP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0342

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0134

C

Seeded From UniProt

complete

GO:0005794

Golgi apparatus

PMID:21968647[2]

ECO:0000314

C

Overexpression of PAQR10/PAQR11 also markedly increased Golgi localization of NRas and KRas4A (Figure2B and 2C), (summarized in Figure 2E).

complete
CACAO 2192

GO:0072600

establishment of protein localization in Golgi

PMID:21968647[2]

ECO:0000315

P

Figure 2B

complete
CACAO 2193

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Halkein, J et al. (2013) MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy. J. Clin. Invest. 123 2143-54 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Jin, T et al. (2012) PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Res. 22 661-76 PubMed GONUTS page
  3. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  4. ↑ 4.0 4.1 Yin, C et al. (2019) Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell 176 1113-1127.e16 PubMed GONUTS page
  5. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  6. ↑ Ahmed, SM et al. (2012) KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J. Cell Biol. 199 951-67 PubMed GONUTS page
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