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HUMAN:RASL2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RASA4 (synonyms: CAPRI, GAPL, KIAA0538)
Protein Name(s) Ras GTPase-activating protein 4

Calcium-promoted Ras inactivator Ras p21 protein activator 4 RasGAP-activating-like protein 2

External Links
UniProt O43374
EMBL AY029206
AB011110
AK026441
AC004084
AC093668
AC105052
BC113663
CCDS CCDS47674.1
CCDS5725.1
RefSeq NP_001073346.2
NP_008920.5
UniGene Hs.530089
Hs.656696
ProteinModelPortal O43374
SMR O43374
BioGrid 115458
IntAct O43374
MINT MINT-1370707
STRING 9606.ENSP00000262940
PhosphoSite O43374
MaxQB O43374
PaxDb O43374
PRIDE O43374
DNASU 10156
Ensembl ENST00000262940
ENST00000449970
GeneID 10156
KEGG hsa:10156
UCSC uc003vae.3
uc010lih.2
CTD 10156
GeneCards GC07M102220
H-InvDB HIX0034020
HIX0201129
HGNC HGNC:23181
HPA HPA043010
MIM 607943
neXtProt NX_O43374
PharmGKB PA134889495
eggNOG COG5038
GeneTree ENSGT00760000119092
HOGENOM HOG000234324
HOVERGEN HBG106587
InParanoid O43374
KO K17630
OMA EVKLGTQ
OrthoDB EOG7J17Z6
PhylomeDB O43374
TreeFam TF105302
ChiTaRS RASA4
GeneWiki RASA4
GenomeRNAi 10156
NextBio 38444
PRO PR:O43374
Proteomes UP000005640
Bgee O43374
CleanEx HS_RASA4
ExpressionAtlas O43374
Genevestigator O43374
GO GO:0005737
GO:0005829
GO:0031235
GO:0005096
GO:0046872
GO:0005099
GO:0071277
GO:0035556
GO:0046580
GO:0032320
Gene3D 1.10.506.10
2.30.29.30
2.60.40.150
4.10.1130.10
InterPro IPR000008
IPR001849
IPR011993
IPR023152
IPR001936
IPR008936
IPR001562
Pfam PF00779
PF00168
PF00616
PRINTS PR00360
SMART SM00107
SM00239
SM00233
SM00323
SUPFAM SSF48350
SSF49562
PROSITE PS50004
PS50003
PS00509
PS50018
PS51113

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0034261

negative regulation of Ras GTPase activity

PMID:12845332[1]

ECO:0000314

P

Fig 5b; over- and underexpression to determine role of CAPRI; directly blocks Ras activation

complete
CACAO 2540

GO:0034261

negative regulation of Ras GTPase activity

PMID:11448776[2]

ECO:0000315

P

Fig 3; mutant and wild-type compared to determine CAPRI's role in Ras activation;

complete
CACAO 2545

involved_in

GO:0034260

negative regulation of GTPase activity

PMID:11448776[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034260

negative regulation of GTPase activity

PMID:12845332[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:16009725[3]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_at:(GO:0005886)

Seeded From UniProt

complete

colocalizes_with

GO:0005886

plasma membrane

PMID:16009725[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16009725[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0071277

cellular response to calcium ion

PMID:16009725[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:11448776[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037777

F

Seeded From UniProt

complete

enables

GO:0005543

phospholipid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037777

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008936

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001562

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001936
InterPro:IPR023152

P

Seeded From UniProt

complete

involved_in

GO:0046580

negative regulation of Ras protein signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037777

P

Seeded From UniProt

complete

involved_in

GO:0071277

cellular response to calcium ion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037777

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-6802834
Reactome:R-HSA-5658435
Reactome:R-HSA-5658231

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

Reactome:R-HSA-5673001

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0343

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Bivona, TG et al. (2003) Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature 424 694-8 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Lockyer, PJ et al. (2001) CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway. Curr. Biol. 11 981-6 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Liu, Q et al. (2005) CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. J. Cell Biol. 170 183-90 PubMed GONUTS page
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