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HUMAN:RASA2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) RASA2 (synonyms: GAP1M, RASGAP)
Protein Name(s) Ras GTPase-activating protein 2

GTPase-activating protein 1m GAP1m

External Links
UniProt Q15283
EMBL D78155
D78156
D82880
D82881
AF115573
AC010184
AC092977
CH471052
AK292016
CCDS CCDS3117.1
PIR JC5047
RefSeq NP_001290174.1
NP_001290175.1
NP_006497.2
UniGene Hs.655941
Hs.98445
ProteinModelPortal Q15283
SMR Q15283
BioGrid 111857
STRING 9606.ENSP00000286364
iPTMnet Q15283
PhosphoSite Q15283
BioMuta RASA2
DMDM 519668674
MaxQB Q15283
PaxDb Q15283
PRIDE Q15283
DNASU 5922
Ensembl ENST00000286364
GeneID 5922
KEGG hsa:5922
UCSC uc003etz.1
uc003eua.1
CTD 5922
GeneCards RASA2
HGNC HGNC:9872
HPA HPA035374
HPA035375
MalaCards RASA2
MIM 601589
neXtProt NX_Q15283
Orphanet 648
PharmGKB PA34233
eggNOG KOG2059
ENOG410Y128
GeneTree ENSGT00760000119092
HOGENOM HOG000007183
HOVERGEN HBG055643
InParanoid Q15283
KO K08053
OrthoDB EOG7J17Z6
PhylomeDB Q15283
TreeFam TF105302
Reactome R-HSA-5658442
ChiTaRS RASA2
GenomeRNAi 5922
NextBio 23062
PRO PR:Q15283
Proteomes UP000005640
Bgee Q15283
CleanEx HS_RASA2
ExpressionAtlas Q15283
Genevisible Q15283
GO GO:0005737
GO:0005829
GO:0031235
GO:0048471
GO:0005096
GO:0046872
GO:0000186
GO:0007411
GO:0007173
GO:0038095
GO:0008543
GO:0045087
GO:0008286
GO:0000165
GO:0046580
GO:0048011
GO:0043547
GO:0007265
GO:0007165
GO:0007264
GO:0048010
Gene3D 1.10.506.10
2.30.29.30
2.60.40.150
InterPro IPR000008
IPR011993
IPR001849
IPR023152
IPR001936
IPR008936
IPR001562
Pfam PF00779
PF00168
PF00169
PF00616
PRINTS PR00402
SMART SM00107
SM00239
SM00233
SM00323
SUPFAM SSF48350
SSF49562
SSF50729
PROSITE PS50004
PS50003
PS00509
PS50018
PS51113

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

involved_in

GO:0043547

positive regulation of GTPase activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005096

P

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q63713
ensembl:ENSRNOP00000016327

F

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037773

F

Seeded From UniProt

complete

enables

GO:0005543

phospholipid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037773

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008936

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001562

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001936
InterPro:IPR023152

P

Seeded From UniProt

complete

involved_in

GO:0046580

negative regulation of Ras protein signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037773

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:8812506[1]
PMID:8699317[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

PMID:8812506[1]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-6802834
Reactome:R-HSA-5658435
Reactome:R-HSA-5658231

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

Reactome:R-HSA-5673001

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0005096

GTPase activator activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0343

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0198

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Li, S et al. (1996) cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras. Genomics 35 625-7 PubMed GONUTS page
  2. Hattori, S & Baba, H (1996) [Heterogeneity of GTPase-activating proteins for Ras in the regulation of Ras signal transduction pathway]. Yakugaku Zasshi 116 21-38 PubMed GONUTS page