HUMAN:QSOX1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	QSOX1 (synonyms: QSCN6)
Protein Name(s)	Sulfhydryl oxidase 1 hQSOX Quiescin Q6
External Links
UniProt	O00391
EMBL	U97276 AF361868 AY358941 AB209280 AL390718 AL390718 BC017692 BC100023
CCDS	CCDS1337.1 CCDS30950.1
RefSeq	NP_001004128.1 NP_002817.2
UniGene	Hs.744925
PDB	3LLI 3LLK 3Q6O 4IJ3
PDBsum	3LLI 3LLK 3Q6O 4IJ3
ProteinModelPortal	O00391
SMR	O00391
BioGrid	111734
IntAct	O00391
MINT	MINT-2862351
STRING	9606.ENSP00000356574
PhosphoSite	O00391
MaxQB	O00391
PaxDb	O00391
PeptideAtlas	O00391
PRIDE	O00391
DNASU	5768
Ensembl	ENST00000367600 ENST00000367602
GeneID	5768
KEGG	hsa:5768
UCSC	uc001gny.3 uc001gnz.3
CTD	5768
GeneCards	GC01P180123
HGNC	HGNC:9756
HPA	HPA042127
MIM	603120
neXtProt	NX_O00391
PharmGKB	PA162400559
eggNOG	COG0526
GeneTree	ENSGT00390000008045
HOGENOM	HOG000231631
HOVERGEN	HBG080360
InParanoid	O00391
KO	K10758
OMA	SHNRVNA
OrthoDB	EOG73RB9X
PhylomeDB	O00391
TreeFam	TF316749
BRENDA	1.8.3.2
ChiTaRS	QSOX1
EvolutionaryTrace	O00391
GeneWiki	QSOX1
GenomeRNAi	5768
NextBio	22434
PRO	PR:O00391
Proteomes	UP000005640
Bgee	O00391
CleanEx	HS_QSOX1
ExpressionAtlas	O00391
Genevestigator	O00391
GO	GO:0005615 GO:0070062 GO:0030173 GO:0016971 GO:0003756 GO:0045454 GO:0006457
Gene3D	1.20.120.310 3.40.30.10
InterPro	IPR017905 IPR012336 IPR013766
Pfam	PF04777 PF00085
SUPFAM	SSF52833 SSF69000
PROSITE	PS51324 PS51352

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016242	negative regulation of macroautophagy	PMID:24475161^[1]	ECO:0000315			P		Figure 2: Western blot shows that QSOX1 regulates the levels of autophagic markers p62 and LC3-II.	complete CACAO 9402
involved_in	GO:0085029	extracellular matrix assembly	PMID:23867277^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0071949	FAD binding	PMID:20211621^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	PMID:29757379^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016242	negative regulation of macroautophagy	PMID:24475161^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21082674^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
part_of	GO:0030173	integral component of Golgi membrane	PMID:17331072^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016971	flavin-linked sulfhydryl oxidase activity	PMID:17331072^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016971	flavin-linked sulfhydryl oxidase activity	PMID:18393449^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10708601^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003756	protein disulfide isomerase activity	PMID:17331072^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003756	protein disulfide isomerase activity	PMID:18393449^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030173	integral component of Golgi membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000528008 UniProtKB:O00391	C		Seeded From UniProt	complete
enables	GO:0016971	flavin-linked sulfhydryl oxidase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000528008 UniProtKB:O00391	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000528008 UniProtKB:O00391	C		Seeded From UniProt	complete
enables	GO:0003756	protein disulfide isomerase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000528008 UniProtKB:O00391	F		Seeded From UniProt	complete
part_of	GO:0045171	intercellular bridge	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016971	flavin-linked sulfhydryl oxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039798	F		Seeded From UniProt	complete
enables	GO:0016972	thiol oxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017905 InterPro:IPR036774	F		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013766	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017905 InterPro:IPR036774	P		Seeded From UniProt	complete
enables	GO:0016972	thiol oxidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.8.3.2	F		Seeded From UniProt	complete
part_of	GO:1904724	tertiary granule lumen	Reactome:R-HSA-6798745	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035580	specific granule lumen	Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031093	platelet alpha granule lumen	Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6798749 Reactome:R-HSA-6798745 Reactome:R-HSA-481007	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002576	platelet degranulation	Reactome:R-HSA-114608	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Poillet, L et al. (2014) QSOX1 inhibits autophagic flux in breast cancer cells. PLoS ONE 9 e86641 PubMed GONUTS page
↑ Grossman, I et al. (2013) An inhibitory antibody blocks the first step in the dithiol/disulfide relay mechanism of the enzyme QSOX1. J. Mol. Biol. 425 4366-78 PubMed GONUTS page
↑ Alon, A et al. (2010) QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains. FEBS Lett. 584 1521-5 PubMed GONUTS page
↑ Horowitz, B et al. (2018) Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization. Glycobiology 28 580-591 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Zhang, Y et al. (2010) Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. Electrophoresis 31 3797-807 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Chakravarthi, S et al. (2007) Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1. Biochem. J. 404 403-11 PubMed GONUTS page
↑ ^9.0 ^9.1 Heckler, EJ et al. (2008) Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis. Biochemistry 47 4955-63 PubMed GONUTS page
↑ Coppock, D et al. (2000) Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. Biochem. Biophys. Res. Commun. 269 604-10 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24475161-1] 1.0 ^1.1 Poillet, L et al. (2014) QSOX1 inhibits autophagic flux in breast cancer cells. PLoS ONE 9 e86641 PubMed GONUTS page

[PMID:23867277-2] Grossman, I et al. (2013) An inhibitory antibody blocks the first step in the dithiol/disulfide relay mechanism of the enzyme QSOX1. J. Mol. Biol. 425 4366-78 PubMed GONUTS page

[PMID:20211621-3] Alon, A et al. (2010) QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains. FEBS Lett. 584 1521-5 PubMed GONUTS page

[PMID:29757379-4] Horowitz, B et al. (2018) Quiescin sulfhydryl oxidase 1 (QSOX1) glycosite mutation perturbs secretion but not Golgi localization. Glycobiology 28 580-591 PubMed GONUTS page

[PMID:23533145-5] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:21082674-6] Zhang, Y et al. (2010) Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS. Electrophoresis 31 3797-807 PubMed GONUTS page

[PMID:16502470-7] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:17331072-8] 8.0 ^8.1 ^8.2 Chakravarthi, S et al. (2007) Intracellular catalysis of disulfide bond formation by the human sulfhydryl oxidase, QSOX1. Biochem. J. 404 403-11 PubMed GONUTS page

[PMID:18393449-9] 9.0 ^9.1 Heckler, EJ et al. (2008) Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis. Biochemistry 47 4955-63 PubMed GONUTS page

[PMID:10708601-10] Coppock, D et al. (2000) Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. Biochem. Biophys. Res. Commun. 269 604-10 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

HUMAN:QSOX1

Contents

Annotations

Notes

References

c

e

f

g

h

i

m

n

o

p

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools