HUMAN:Q96IH1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FSCN1
Protein Name(s)	Fascin
External Links
UniProt	Q96IH1
EMBL	BC007539
UniGene	Hs.118400
MINT	MINT-1375527
PRIDE	Q96IH1
HOGENOM	HOG000267034
HOVERGEN	HBG000968
ChiTaRS	FSCN1
ArrayExpress	Q96IH1
Bgee	Q96IH1
GO	GO:0005737 GO:0005856 GO:0030175 GO:0008144 GO:0051017 GO:0016477
InterPro	IPR008999 IPR010431 IPR022768 IPR024703
PANTHER	PTHR10551
Pfam	PF06268
PIRSF	PIRSF005682
SUPFAM	SSF50405

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0045296	cadherin binding	PMID:25468996^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035089	establishment of apical/basal cell polarity	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010592	positive regulation of lamellipodium assembly	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032534	regulation of microvillus assembly	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007043	cell-cell junction assembly	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0044393	microspike	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005902	microvillus	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030035	microspike assembly	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031253	cell projection membrane	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090091	positive regulation of extracellular matrix disassembly	PMID:20137952^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	PMID:20137952^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044393	microspike	PMID:20137952^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030035	microspike assembly	PMID:20137952^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	PMID:20137952^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:20137952^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0002102	podosome	PMID:20137952^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071803	positive regulation of podosome assembly	PMID:20137952^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61553	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61553	C		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	PMID:3525578^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0044393	microspike	PMID:3525578^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
part_of	GO:0071437	invadopodium	PMID:20137952^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	PMID:20393565^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:8999969^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048870	cell motility	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	PMID:3525578^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:9571235^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:20393565^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	PMID:3525578^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008144	drug binding	PMID:20393565^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:20393565^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	PMID:8999969^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	PMID:3525578^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003447 MGI:MGI:1352745 PANTHER:PTN000058080 RGD:1583309 UniProtKB:Q16658	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352745 PANTHER:PTN000058080 UniProtKB:Q16658	F		Seeded From UniProt	complete
part_of	GO:0031253	cell projection membrane	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000058113 UniProtKB:Q16658	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352745 PANTHER:PTN000058113 RGD:1583309	C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352745 PANTHER:PTN000058113 RGD:1583309 UniProtKB:Q16658	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352745 PANTHER:PTN000058113 RGD:1583309	C		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352745 PANTHER:PTN000058080 UniProtKB:Q16658	P		Seeded From UniProt	complete
involved_in	GO:0007163	establishment or maintenance of cell polarity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003447 PANTHER:PTN000058080	P		Seeded From UniProt	complete
part_of	GO:0005902	microvillus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000058113 RGD:1583309 UniProtKB:Q16658	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003447 MGI:MGI:1890386 PANTHER:PTN000058080 RGD:1583309 UniProtKB:Q16658	C		Seeded From UniProt	complete
part_of	GO:0001726	ruffle	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000058113 RGD:1583309 UniProtKB:Q16658	C		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	PMID:17671164^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61553 ensembl:ENSMUSP00000031565	P		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61553 ensembl:ENSMUSP00000031565	F		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61553 ensembl:ENSMUSP00000031565	C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61553 ensembl:ENSMUSP00000031565	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61553 ensembl:ENSMUSP00000031565	C		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61553 ensembl:ENSMUSP00000031565	P		Seeded From UniProt	complete
enables	GO:0008144	drug binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61553 ensembl:ENSMUSP00000031565	F		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61553 ensembl:ENSMUSP00000031565	F		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010431	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030146	P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030146	P		Seeded From UniProt	complete
enables	GO:0030674	protein binding, bridging	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022768 InterPro:IPR024703	F		Seeded From UniProt	complete
enables	GO:0051015	actin filament binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010431 InterPro:IPR022768 InterPro:IPR024703 InterPro:IPR030146	F		Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	PMID:8647875^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:8647875^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0015629	actin cytoskeleton	PMID:8647875^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-6790041	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965 UniProtKB-SubCell:SL-0038	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
part_of	GO:0005902	microvillus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0293	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
part_of	GO:0071437	invadopodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0148	C		Seeded From UniProt	complete
part_of	GO:0030175	filopodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0286	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 Yamashiro, S et al. (1998) Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol. Biol. Cell 9 993-1006 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Li, A et al. (2010) The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr. Biol. 20 339-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Yamashiro-Matsumura, S & Matsumura, F (1986) Intracellular localization of the 55-kD actin-bundling protein in cultured cells: spatial relationships with actin, alpha-actinin, tropomyosin, and fimbrin. J. Cell Biol. 103 631-40 PubMed GONUTS page
↑ ^5.0 ^5.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Chen, L et al. (2010) Migrastatin analogues target fascin to block tumour metastasis. Nature 464 1062-6 PubMed GONUTS page
↑ ^7.0 ^7.1 Ono, S et al. (1997) Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. J. Biol. Chem. 272 2527-33 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Aratyn, YS et al. (2007) Intrinsic dynamic behavior of fascin in filopodia. Mol. Biol. Cell 18 3928-40 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Yamakita, Y et al. (1996) Phosphorylation of human fascin inhibits its actin binding and bundling activities. J. Biol. Chem. 271 12632-8 PubMed GONUTS page

[PMID:25468996-1] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:9571235-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 Yamashiro, S et al. (1998) Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol. Biol. Cell 9 993-1006 PubMed GONUTS page

[PMID:20137952-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 Li, A et al. (2010) The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr. Biol. 20 339-45 PubMed GONUTS page

[PMID:3525578-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Yamashiro-Matsumura, S & Matsumura, F (1986) Intracellular localization of the 55-kD actin-bundling protein in cultured cells: spatial relationships with actin, alpha-actinin, tropomyosin, and fimbrin. J. Cell Biol. 103 631-40 PubMed GONUTS page

[PMID:20458337-5] 5.0 ^5.1 Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:20393565-6] 6.0 ^6.1 ^6.2 ^6.3 Chen, L et al. (2010) Migrastatin analogues target fascin to block tumour metastasis. Nature 464 1062-6 PubMed GONUTS page

[PMID:8999969-7] 7.0 ^7.1 Ono, S et al. (1997) Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin. J. Biol. Chem. 272 2527-33 PubMed GONUTS page

[PMID:22658674-8] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:21873635-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17671164-10] Aratyn, YS et al. (2007) Intrinsic dynamic behavior of fascin in filopodia. Mol. Biol. Cell 18 3928-40 PubMed GONUTS page

[PMID:8647875-11] 11.0 ^11.1 ^11.2 Yamakita, Y et al. (1996) Phosphorylation of human fascin inhibits its actin binding and bundling activities. J. Biol. Chem. 271 12632-8 PubMed GONUTS page

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HUMAN:Q96IH1

Contents

Annotations

Notes

References

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