HUMAN:PRIO

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PRNP (synonyms: ALTPRP, PRIP, PRP)
Protein Name(s)	Major prion protein PrP ASCR PrP27-30 PrP33-35C
External Links
UniProt	P04156
EMBL	M13899 X83416 U29185 AF076976 AY008282 DQ408531 AL133396 AL133396 BC012844 BC022532 D00015 M13667 M81929 M81930 AF030575 S80732 S80743 S71208 S71210 S71212
CCDS	CCDS13080.1
PIR	A24173
RefSeq	NP_000302.1 NP_001073590.1 NP_001073591.1 NP_001073592.1 NP_898902.1
UniGene	Hs.472010 Hs.610285 Hs.721670
PDB	1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O
PDBsum	1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O
DisProt	DP00466
ProteinModelPortal	P04156
SMR	P04156
BioGrid	111606
DIP	DIP-29933N
IntAct	P04156
MINT	MINT-1420984
BindingDB	P04156
ChEMBL	CHEMBL4869
DrugBank	DB00759
PhosphoSite	P04156
DMDM	130912
MaxQB	P04156
PaxDb	P04156
PRIDE	P04156
DNASU	5621
Ensembl	ENST00000379440 ENST00000430350
GeneID	5621
KEGG	hsa:5621
UCSC	uc002wkt.1
CTD	5621
GeneCards	GC20P004615
GeneReviews	PRNP
HGNC	HGNC:9449
HPA	HPA042754
MIM	123400 137440 176640 245300 600072 603218 606688
neXtProt	NX_P04156
Orphanet	397606 280397 466 356 157941 282166
PharmGKB	PA33796
eggNOG	NOG41716
HOVERGEN	HBG008260
InParanoid	P04156
KO	K05634
OMA	QVYYRPV
OrthoDB	EOG7DRJ4Q
PhylomeDB	P04156
TreeFam	TF105188
Reactome	REACT_18312
ChiTaRS	PRNP
EvolutionaryTrace	P04156
GenomeRNAi	5621
NextBio	21844
PMAP-CutDB	P04156
PRO	PR:P04156
Proteomes	UP000005640
Bgee	P04156
ExpressionAtlas	P04156
Genevestigator	P04156
GO	GO:0031225 GO:0009986 GO:0005737 GO:0005783 GO:0070062 GO:0019898 GO:0005794 GO:0045121 GO:0005634 GO:0005886 GO:0005507 GO:0042802 GO:0008017 GO:0015631 GO:0007411 GO:0007050 GO:0006878 GO:0007611 GO:0008152 GO:0046007 GO:0043066 GO:0070885 GO:0032689 GO:0032700 GO:0032703 GO:0001933 GO:0043433 GO:0050860 GO:0051260 GO:1901379 GO:0032880 GO:0046686 GO:0046688 GO:0006979
Gene3D	1.10.790.10
InterPro	IPR000817 IPR022416 IPR025860
PANTHER	PTHR11522
Pfam	PF00377 PF11587
PRINTS	PR00341
SMART	SM00157
SUPFAM	SSF54098
PROSITE	PS00291 PS00706

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043524	negative regulation of apoptotic process	PMID:19633190^[1]	ECO:0000314			P		Fig. 2	complete CACAO 7825
enables	GO:0005539	glycosaminoglycan binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	F	directly_positively_regulates:(GO:0002020) negatively_regulates:(GO:0042987)	Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	PMID:20564047^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	PMID:20564047^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:20564047^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031648	protein destabilization	PMID:20564047^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20564047^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	PMID:20564047^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	F		Seeded From UniProt	complete
involved_in	GO:1902992	negative regulation of amyloid precursor protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	has_output:(UniProtKB:P05067:PRO_0000000090) has_regulation_target:(UniProtKB:P56817) regulates_o_occurs_in:(GO:0045121)	Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0000850) occurs_in:(GO:0030424)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	part_of:(GO:0090647) happens_during:(GO:0007568)	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:24012003^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P41594	P	occurs_in:(CL:0000540) regulates:(GO:0035584)	Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	PMID:24012003^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P41594	P	part_of:(GO:1904646) occurs_in:(CL:0000540)	Seeded From UniProt	complete
colocalizes_with	GO:0030425	dendrite	PMID:24012003^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:24012003^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
NOT\|enables	GO:0031805	type 8 metabotropic glutamate receptor binding	PMID:24012003^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1902938	regulation of intracellular calcium activated chloride channel activity	PMID:24012003^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P41594	P		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	PMID:24012003^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P41594	F		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:24012003^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134,UniProtKB:P41594	P	has_regulation_target:(UniProtKB:P06241)	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:22820466^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:P39688)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:22820466^[4]	ECO:0000353	physical interaction evidence used in manual assertion	CHEBI:64647	F	positively_regulates:(GO:0018108)	Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	F	occurs_in:(UBERON:0002421) regulates:(GO:0060291)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	F	has_direct_input:(UniProtKB:P12023:PRO_0000000118) part_of:(GO:1900272)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	F	has_direct_input:(ComplexPortal:CPX-1139) part_of:(GO:1900272)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:23386614^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18419754^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:18419754^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:19581412^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900449	regulation of glutamate receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
involved_in	GO:0050860	negative regulation of T cell receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
involved_in	GO:0046007	negative regulation of activated T cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
involved_in	GO:0032703	negative regulation of interleukin-2 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:23386614^[5]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1134	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	C		Seeded From UniProt	complete
enables	GO:0015631	tubulin binding	PMID:16004966^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:16004966^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P		Seeded From UniProt	complete
involved_in	GO:0006878	cellular copper ion homeostasis	PMID:16004966^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	C		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:11900542^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031362	anchored component of external side of plasma membrane	PMID:22293988^[11]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P13852	C		Seeded From UniProt	complete
involved_in	GO:1905664	regulation of calcium ion import across plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609) causally_upstream_of:(GO:1901216) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609)	Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609) part_of:(GO:1904646)	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609) part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:Q13224) regulates:(GO:0098703)	Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P04925	P	occurs_in:(CL:0002609) part_of:(GO:1904645) has_regulation_target:(UniProtKB:Q13224)	Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
enables	GO:1903136	cuprous ion binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:1903135	cupric ion binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	F		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
involved_in	GO:1900449	regulation of glutamate receptor signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	F		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156 UniProtKB:P27177	P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	F		Seeded From UniProt	complete
involved_in	GO:0043086	negative regulation of catalytic activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
enables	GO:0043008	ATP-dependent protein binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	F		Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	P		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 RGD:3410 UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 RGD:3410	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN002574842 RGD:3410 UniProtKB:P04156 UniProtKB:P09525	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002574842 UniProtKB:P04156 UniProtKB:P13214	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN002574842 RGD:3410 UniProtKB:P04156 UniProtKB:P09525 UniProtKB:P13214	C		Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	F		Seeded From UniProt	complete
enables	GO:0005521	lamin binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000162591 RGD:3410	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591	F		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97769 PANTHER:PTN000162591 UniProtKB:P04156	F		Seeded From UniProt	complete
involved_in	GO:0071280	cellular response to copper ion	PMID:16254249^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:16254249^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:16254249^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21920025^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19927125^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19278656^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19204296^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18436646^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18025469^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16286452^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04156	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1990535	neuron projection maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:1905664	regulation of calcium ion import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:1904645	response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
enables	GO:1903135	cupric ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	F		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:1902992	negative regulation of amyloid precursor protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:1902951	negative regulation of dendritic spine maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:1902430	negative regulation of amyloid-beta formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:1901379	regulation of potassium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:1900449	regulation of glutamate receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0090647	modulation of age-related behavioral decline	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0050860	negative regulation of T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0046007	negative regulation of activated T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	F		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	F		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0035584	calcium-mediated signaling using intracellular calcium source	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0032703	negative regulation of interleukin-2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	C		Seeded From UniProt	complete
involved_in	GO:0010942	positive regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	C		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	C		Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	F		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04925 ensembl:ENSMUSP00000088833	F		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
involved_in	GO:1900272	negative regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
involved_in	GO:0046688	response to copper ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0046686	response to cadmium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
involved_in	GO:0043086	negative regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
enables	GO:0043008	ATP-dependent protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
enables	GO:0031802	type 5 metabotropic glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	C		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	C		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	C		Seeded From UniProt	complete
enables	GO:0005521	lamin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P13852 ensembl:ENSRNOP00000028881	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000817 InterPro:IPR022416 InterPro:IPR036924	C		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000817 InterPro:IPR022416 InterPro:IPR036924	P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:26871627^[21] PMID:21593310^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:24970228^[23] PMID:19242475^[24] PMID:16294306^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	PMID:26224839^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097062	dendritic spine maintenance	PMID:25707991^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	part_of:(GO:1904645)	Seeded From UniProt	complete
involved_in	GO:0010955	negative regulation of protein processing	PMID:23386614^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:P05067) negatively_regulates:(GO:0034205)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	PMID:22820466^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007616	long-term memory	PMID:19242475^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0019898	extrinsic component of membrane	PMID:16004966^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16004966^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0031225	anchored component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0336	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0338	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Manuelidis, L et al. (2009) The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt-Jakob disease and scrapie agents. Proc. Natl. Acad. Sci. U.S.A. 106 13529-34 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Wu, D et al. (2010) Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment. J. Cell. Biochem. 111 627-33 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Um, JW et al. (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron 79 887-902 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Um, JW et al. (2012) Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat. Neurosci. 15 1227-35 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Rushworth, JV et al. (2013) Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J. Biol. Chem. 288 8935-51 PubMed GONUTS page
↑ ^6.0 ^6.1 Heiseke, A et al. (2008) The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. Traffic 9 1116-29 PubMed GONUTS page
↑ Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Nieznanski, K et al. (2005) Direct interaction between prion protein and tubulin. Biochem. Biophys. Res. Commun. 334 403-11 PubMed GONUTS page
↑ Burns, CS et al. (2002) Molecular features of the copper binding sites in the octarepeat domain of the prion protein. Biochemistry 41 3991-4001 PubMed GONUTS page
↑ Pflanzner, T et al. (2012) Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier. J. Cereb. Blood Flow Metab. 32 628-32 PubMed GONUTS page
↑ ^12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 ^12.23 ^12.24 ^12.25 ^12.26 ^12.27 ^12.28 ^12.29 ^12.30 ^12.31 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Taylor, DR et al. (2005) Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J. Cell. Sci. 118 5141-53 PubMed GONUTS page
↑ Liao, TY et al. (2011) Leu138 in bovine prion peptide fibrils is involved in seeding discrimination related to codon 129 M/V polymorphism in the prion peptide seeding experiment. FEBS J. 278 4351-61 PubMed GONUTS page
↑ Lee, S et al. (2010) Conformational diversity in prion protein variants influences intermolecular beta-sheet formation. EMBO J. 29 251-62 PubMed GONUTS page
↑ Walsh, P et al. (2009) Core structure of amyloid fibrils formed by residues 106-126 of the human prion protein. Structure 17 417-26 PubMed GONUTS page
↑ Antonyuk, SV et al. (2009) Crystal structure of human prion protein bound to a therapeutic antibody. Proc. Natl. Acad. Sci. U.S.A. 106 2554-8 PubMed GONUTS page
↑ Helmus, JJ et al. (2008) Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils. Proc. Natl. Acad. Sci. U.S.A. 105 6284-9 PubMed GONUTS page
↑ Cobb, NJ et al. (2007) Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure. Proc. Natl. Acad. Sci. U.S.A. 104 18946-51 PubMed GONUTS page
↑ Gobbi, M et al. (2006) Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model. J. Biol. Chem. 281 843-9 PubMed GONUTS page
↑ De Strooper, B & Karran, E (2016) The Cellular Phase of Alzheimer's Disease. Cell 164 603-15 PubMed GONUTS page
↑ Barry, AE et al. (2011) Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J. Neurosci. 31 7259-63 PubMed GONUTS page
↑ Kojima, A et al. (2014) Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding. Biomolecules 4 510-26 PubMed GONUTS page
↑ ^24.0 ^24.1 Laurén, J et al. (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457 1128-32 PubMed GONUTS page
↑ Strom, A et al. (2006) Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry. Proteomics 6 26-34 PubMed GONUTS page
↑ Ohnishi, T et al. (2015) Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc. Natl. Acad. Sci. U.S.A. 112 E4465-74 PubMed GONUTS page
↑ Kaufman, AC et al. (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann. Neurol. 77 953-71 PubMed GONUTS page

[PMID:19633190-1] Manuelidis, L et al. (2009) The kuru infectious agent is a unique geographic isolate distinct from Creutzfeldt-Jakob disease and scrapie agents. Proc. Natl. Acad. Sci. U.S.A. 106 13529-34 PubMed GONUTS page

[PMID:20564047-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Wu, D et al. (2010) Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment. J. Cell. Biochem. 111 627-33 PubMed GONUTS page

[PMID:24012003-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 Um, JW et al. (2013) Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein. Neuron 79 887-902 PubMed GONUTS page

[PMID:22820466-4] 4.0 ^4.1 ^4.2 Um, JW et al. (2012) Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. Nat. Neurosci. 15 1227-35 PubMed GONUTS page

[PMID:23386614-5] 5.0 ^5.1 ^5.2 Rushworth, JV et al. (2013) Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1. J. Biol. Chem. 288 8935-51 PubMed GONUTS page

[PMID:18419754-6] 6.0 ^6.1 Heiseke, A et al. (2008) The novel sorting nexin SNX33 interferes with cellular PrP formation by modulation of PrP shedding. Traffic 9 1116-29 PubMed GONUTS page

[PMID:19581412-7] Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page

[PMID:19056867-8] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:16004966-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Nieznanski, K et al. (2005) Direct interaction between prion protein and tubulin. Biochem. Biophys. Res. Commun. 334 403-11 PubMed GONUTS page

[PMID:11900542-10] Burns, CS et al. (2002) Molecular features of the copper binding sites in the octarepeat domain of the prion protein. Biochemistry 41 3991-4001 PubMed GONUTS page

[PMID:22293988-11] Pflanzner, T et al. (2012) Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier. J. Cereb. Blood Flow Metab. 32 628-32 PubMed GONUTS page

[PMID:21873635-12] 12.00 ^12.01 ^12.02 ^12.03 ^12.04 ^12.05 ^12.06 ^12.07 ^12.08 ^12.09 ^12.10 ^12.11 ^12.12 ^12.13 ^12.14 ^12.15 ^12.16 ^12.17 ^12.18 ^12.19 ^12.20 ^12.21 ^12.22 ^12.23 ^12.24 ^12.25 ^12.26 ^12.27 ^12.28 ^12.29 ^12.30 ^12.31 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16254249-13] 13.0 ^13.1 ^13.2 Taylor, DR et al. (2005) Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. J. Cell. Sci. 118 5141-53 PubMed GONUTS page

[PMID:21920025-14] Liao, TY et al. (2011) Leu138 in bovine prion peptide fibrils is involved in seeding discrimination related to codon 129 M/V polymorphism in the prion peptide seeding experiment. FEBS J. 278 4351-61 PubMed GONUTS page

[PMID:19927125-15] Lee, S et al. (2010) Conformational diversity in prion protein variants influences intermolecular beta-sheet formation. EMBO J. 29 251-62 PubMed GONUTS page

[PMID:19278656-16] Walsh, P et al. (2009) Core structure of amyloid fibrils formed by residues 106-126 of the human prion protein. Structure 17 417-26 PubMed GONUTS page

[PMID:19204296-17] Antonyuk, SV et al. (2009) Crystal structure of human prion protein bound to a therapeutic antibody. Proc. Natl. Acad. Sci. U.S.A. 106 2554-8 PubMed GONUTS page

[PMID:18436646-18] Helmus, JJ et al. (2008) Molecular conformation and dynamics of the Y145Stop variant of human prion protein in amyloid fibrils. Proc. Natl. Acad. Sci. U.S.A. 105 6284-9 PubMed GONUTS page

[PMID:18025469-19] Cobb, NJ et al. (2007) Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure. Proc. Natl. Acad. Sci. U.S.A. 104 18946-51 PubMed GONUTS page

[PMID:16286452-20] Gobbi, M et al. (2006) Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model. J. Biol. Chem. 281 843-9 PubMed GONUTS page

[PMID:26871627-21] De Strooper, B & Karran, E (2016) The Cellular Phase of Alzheimer's Disease. Cell 164 603-15 PubMed GONUTS page

[PMID:21593310-22] Barry, AE et al. (2011) Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J. Neurosci. 31 7259-63 PubMed GONUTS page

[PMID:24970228-23] Kojima, A et al. (2014) Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding. Biomolecules 4 510-26 PubMed GONUTS page

[PMID:19242475-24] 24.0 ^24.1 Laurén, J et al. (2009) Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 457 1128-32 PubMed GONUTS page

[PMID:16294306-25] Strom, A et al. (2006) Identification of prion protein binding proteins by combined use of far-Western immunoblotting, two dimensional gel electrophoresis and mass spectrometry. Proteomics 6 26-34 PubMed GONUTS page

[PMID:26224839-26] Ohnishi, T et al. (2015) Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly. Proc. Natl. Acad. Sci. U.S.A. 112 E4465-74 PubMed GONUTS page

[PMID:25707991-27] Kaufman, AC et al. (2015) Fyn inhibition rescues established memory and synapse loss in Alzheimer mice. Ann. Neurol. 77 953-71 PubMed GONUTS page

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