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HUMAN:PORED
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | SRD5A3 (synonyms: SRD5A2L) | |
| Protein Name(s) | Polyprenol reductase
3-oxo-5-alpha-steroid 4-dehydrogenase 3 Steroid 5-alpha-reductase 2-like Steroid 5-alpha-reductase 3 S5AR 3 SR type 3 | |
| External Links | ||
| UniProt | Q9H8P0 | |
| EMBL | AK023414 CR457312 AC064824 CH471057 BC002480 | |
| CCDS | CCDS3498.1 | |
| RefSeq | NP_078868.1 | |
| UniGene | Hs.39311 | |
| ProteinModelPortal | Q9H8P0 | |
| BioGrid | 122772 | |
| IntAct | Q9H8P0 | |
| STRING | 9606.ENSP00000264228 | |
| ChEMBL | CHEMBL2363075 | |
| DrugBank | DB00421 | |
| PhosphoSite | Q9H8P0 | |
| DMDM | 74733864 | |
| MaxQB | Q9H8P0 | |
| PaxDb | Q9H8P0 | |
| PeptideAtlas | Q4W5Q6 | |
| PRIDE | Q9H8P0 | |
| DNASU | 79644 | |
| Ensembl | ENST00000264228 | |
| GeneID | 79644 | |
| KEGG | hsa:79644 | |
| UCSC | uc003hau.3 | |
| CTD | 79644 | |
| GeneCards | GC04P056212 | |
| GeneReviews | SRD5A3 | |
| HGNC | HGNC:25812 | |
| HPA | HPA027006 | |
| MIM | 611715 612379 612713 | |
| neXtProt | NX_Q9H8P0 | |
| Orphanet | 324737 | |
| PharmGKB | PA162404779 | |
| eggNOG | NOG330066 | |
| GeneTree | ENSGT00500000044920 | |
| HOVERGEN | HBG057797 | |
| InParanoid | Q9H8P0 | |
| KO | K12345 | |
| OMA | WLHSARR | |
| OrthoDB | EOG72ZCFT | |
| PhylomeDB | Q9H8P0 | |
| TreeFam | TF315011 | |
| BioCyc | MetaCyc:HS13249-MONOMER | |
| Reactome | REACT_11059 REACT_22230 | |
| UniPathway | UPA00378 | |
| ChiTaRS | SRD5A3 | |
| GeneWiki | SRD5A3 | |
| GenomeRNAi | 79644 | |
| NextBio | 68779 | |
| PRO | PR:Q9H8P0 | |
| Proteomes | UP000005640 | |
| Bgee | Q9H8P0 | |
| CleanEx | HS_SRD5A3 | |
| ExpressionAtlas | Q9H8P0 | |
| Genevestigator | Q9H8P0 | |
| GO | GO:0005783 GO:0005789 GO:0016021 GO:0003865 GO:0047751 GO:0016628 GO:0006702 GO:0044267 GO:0019348 GO:0006488 GO:0006489 GO:0016095 GO:0043687 GO:0018279 GO:0044281 GO:0008202 | |
| InterPro | IPR001104 | |
| Pfam | PF02544 | |
| PROSITE | PS50244 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0019348 |
dolichol metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016628 |
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016095 |
polyprenol catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006488 |
dolichol-linked oligosaccharide biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003865 |
3-oxo-5-alpha-steroid 4-dehydrogenase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019408 |
dolichol biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000379006 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016095 |
polyprenol catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1930252 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006488 |
dolichol-linked oligosaccharide biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1930252 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000379006 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003865 |
3-oxo-5-alpha-steroid 4-dehydrogenase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000379006 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019348 |
dolichol metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WUP4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016095 |
polyprenol catabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WUP4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006488 |
dolichol-linked oligosaccharide biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9WUP4 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003865 |
3-oxo-5-alpha-steroid 4-dehydrogenase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006488 |
dolichol-linked oligosaccharide biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016627 |
oxidoreductase activity, acting on the CH-CH group of donors |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0102389 |
polyprenol reductase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0047751 |
cholestenone 5-alpha-reductase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016628 |
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor |
Reactome:R-HSA-4419979 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006702 |
androgen biosynthetic process |
Reactome:R-HSA-193048 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006489 |
dolichyl diphosphate biosynthetic process |
Reactome:R-HSA-446199 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-469659 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016491 |
oxidoreductase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00378 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 Cantagrel, V et al. (2010) SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cell 142 203-17 PubMed GONUTS page
- ↑ Uemura, M et al. (2008) Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer. Cancer Sci. 99 81-6 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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