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HUMAN:PLXB2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PLXNB2 (synonyms: KIAA0315)
Protein Name(s) Plexin-B2

MM1

External Links
UniProt O15031
EMBL AB002313
AL022328
BX649592
BC004542
BT006887
CCDS CCDS43035.1
RefSeq NP_036533.2
XP_005261966.1
XP_005261967.1
XP_005261968.1
XP_006724476.1
XP_016884192.1
XP_016884193.1
UniGene Hs.3989
Hs.736016
PDB 4E71
PDBsum 4E71
ProteinModelPortal O15031
SMR O15031
BioGrid 117178
IntAct O15031
MINT O15031
STRING 9606.ENSP00000352288
iPTMnet O15031
PhosphoSitePlus O15031
SwissPalm O15031
BioMuta PLXNB2
EPD O15031
MaxQB O15031
PaxDb O15031
PeptideAtlas O15031
PRIDE O15031
DNASU 23654
Ensembl ENST00000359337
ENST00000449103
GeneID 23654
KEGG hsa:23654
UCSC uc003bkv.4
CTD 23654
DisGeNET 23654
EuPathDB HostDB:ENSG00000196576.14
GeneCards PLXNB2
HGNC HGNC:9104
HPA HPA003100
MIM 604293
neXtProt NX_O15031
OpenTargets ENSG00000196576
PharmGKB PA33430
eggNOG ENOG410IN3E
ENOG411131Q
GeneTree ENSGT00760000119048
HOGENOM HOG000231376
HOVERGEN HBG053404
InParanoid O15031
KO K06821
OMA KPFHGDI
OrthoDB EOG091G00EK
PhylomeDB O15031
TreeFam TF312962
ChiTaRS PLXNB2
GeneWiki PLXNB2
GenomeRNAi 23654
PRO PR:O15031
Proteomes UP000005640
Bgee ENSG00000196576
CleanEx HS_PLXNB2
ExpressionAtlas O15031
Genevisible O15031
GO GO:0009986
GO:0070062
GO:0005887
GO:0017154
GO:0007420
GO:0007156
GO:0007162
GO:0001843
GO:0007405
GO:0050772
GO:0010976
GO:0008360
GO:0043087
GO:2001222
GO:0001932
GO:0071526
Gene3D 2.130.10.10
2.60.40.10
InterPro IPR013783
IPR014756
IPR002909
IPR031148
IPR013548
IPR002165
IPR016201
IPR008936
IPR001627
IPR036352
IPR015943
PANTHER PTHR22625
Pfam PF08337
PF01437
PF01403
PF01833
SMART SM00429
SM00423
SM00630
SUPFAM SSF101912
SSF48350
SSF81296
PROSITE PS51004

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045727

positive regulation of translation

PMID:29100074[1]

ECO:0000315

P

Fig 6C shows that knockdown of PLXNB2 in the mouse cell line MyePro results in a decrease in protein synthesis.

complete
CACAO 13170

involved_in

GO:1904861

excitatory synapse assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

P

Seeded From UniProt

complete

involved_in

GO:0010976

positive regulation of neuron projection development

PMID:16122393[2]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:1001611)

Seeded From UniProt

complete

involved_in

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

PMID:16122393[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:19581412[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

involved_in

GO:2001222

regulation of neuron migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

P

Seeded From UniProt

complete

involved_in

GO:0071526

semaphorin-plexin signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

P

Seeded From UniProt

complete

enables

GO:0017154

semaphorin receptor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

F

Seeded From UniProt

complete

involved_in

GO:0008360

regulation of cell shape

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

P

Seeded From UniProt

complete

involved_in

GO:0007405

neuroblast proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

C

Seeded From UniProt

complete

involved_in

GO:0001932

regulation of protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

P

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:B2RXS4

P

Seeded From UniProt

complete

involved_in

GO:1902287

semaphorin-plexin signaling pathway involved in axon guidance

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107683
MGI:MGI:2179061
PANTHER:PTN001098994

P

Seeded From UniProt

complete

involved_in

GO:0050772

positive regulation of axonogenesis

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2154238
MGI:MGI:2154239
PANTHER:PTN001861955

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2154239
PANTHER:PTN001861955
ZFIN:ZDB-GENE-030131-1620

P

Seeded From UniProt

complete

involved_in

GO:0030334

regulation of cell migration

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107684
MGI:MGI:2154244
PANTHER:PTN001098994

P

Seeded From UniProt

complete

enables

GO:0017154

semaphorin receptor activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107683
MGI:MGI:107684
MGI:MGI:107685
MGI:MGI:2154238
MGI:MGI:2154239
MGI:MGI:2154244
MGI:MGI:2179061
PANTHER:PTN001098994
UniProtKB:O43157
UniProtKB:Q9ULL4
WB:WBGene00004047
WB:WBGene00004048

F

Seeded From UniProt

complete

involved_in

GO:0008360

regulation of cell shape

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2154238
MGI:MGI:2154239
PANTHER:PTN001861955
UniProtKB:O43157

P

Seeded From UniProt

complete

involved_in

GO:0007162

negative regulation of cell adhesion

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001861955
UniProtKB:O43157
UniProtKB:Q9ULL4

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107684
MGI:MGI:2154239
MGI:MGI:2154244
PANTHER:PTN001098994
UniProtKB:O43157

C

Seeded From UniProt

complete

part_of

GO:0002116

semaphorin receptor complex

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001098994
UniProtKB:O43157

C

Seeded From UniProt

complete

involved_in

GO:2001222

regulation of neuron migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

involved_in

GO:1904861

excitatory synapse assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

involved_in

GO:0071526

semaphorin-plexin signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

involved_in

GO:0050772

positive regulation of axonogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

enables

GO:0017154

semaphorin receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

F

Seeded From UniProt

complete

involved_in

GO:0008360

regulation of cell shape

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

involved_in

GO:0007405

neuroblast proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

C

Seeded From UniProt

complete

involved_in

GO:0001932

regulation of protein phosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

involved_in

GO:0001843

neural tube closure

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:B2RXS4
ensembl:ENSMUSP00000104955

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008936

P

Seeded From UniProt

complete

enables

GO:0017154

semaphorin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031148

F

Seeded From UniProt

complete

involved_in

GO:0071526

semaphorin-plexin signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031148

P

Seeded From UniProt

complete

involved_in

GO:0007275

multicellular organism development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Yu, W et al. (2017) Plexin-B2 Mediates Physiologic and Pathologic Functions of Angiogenin. Cell 171 849-864.e25 PubMed GONUTS page
  2. ↑ 2.0 2.1 Hartwig, C et al. (2005) Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. BMC Neurosci 6 53 PubMed GONUTS page
  3. ↑ Teckchandani, A et al. (2009) Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. J. Cell Biol. 186 99-111 PubMed GONUTS page
  4. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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