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HUMAN:PLPL3
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PNPLA3 (synonyms: ADPN, C22orf20) | |
| Protein Name(s) | Patatin-like phospholipase domain-containing protein 3
Acylglycerol O-acyltransferase Adiponutrin Calcium-independent phospholipase A2-epsilon iPLA2-epsilon | |
| External Links | ||
| UniProt | Q9NST1 | |
| EMBL | AL138578 CR456476 AK123806 AK315166 AL023654 AL035398 AL035398 AL023654 AL023654 AL035398 AL035398 AL023654 CH471138 BC014449 BC065195 | |
| CCDS | CCDS14054.1 | |
| RefSeq | NP_079501.2 | |
| UniGene | Hs.654800 | |
| ProteinModelPortal | Q9NST1 | |
| BioGrid | 123247 | |
| IntAct | Q9NST1 | |
| STRING | 9606.ENSP00000216180 | |
| PhosphoSite | Q9NST1 | |
| DMDM | 32469599 | |
| MaxQB | Q9NST1 | |
| PaxDb | Q9NST1 | |
| PRIDE | Q9NST1 | |
| DNASU | 80339 | |
| Ensembl | ENST00000216180 ENST00000423180 | |
| GeneID | 80339 | |
| KEGG | hsa:80339 | |
| UCSC | uc003bei.1 | |
| CTD | 80339 | |
| GeneCards | GC22P044319 | |
| H-InvDB | HIX0159175 | |
| HGNC | HGNC:18590 | |
| HPA | HPA058058 | |
| MIM | 609567 613282 | |
| neXtProt | NX_Q9NST1 | |
| Orphanet | 33271 | |
| PharmGKB | PA38592 | |
| eggNOG | NOG261571 | |
| GeneTree | ENSGT00390000005295 | |
| HOGENOM | HOG000007467 | |
| HOVERGEN | HBG007046 | |
| InParanoid | Q9NST1 | |
| KO | K13534 | |
| OMA | FDAKTTI | |
| OrthoDB | EOG7J9VQR | |
| PhylomeDB | Q9NST1 | |
| TreeFam | TF314272 | |
| Reactome | REACT_121122 | |
| UniPathway | UPA00256 | |
| GeneWiki | PNPLA3 | |
| GenomeRNAi | 80339 | |
| NextBio | 70910 | |
| PRO | PR:Q9NST1 | |
| Proteomes | UP000005640 | |
| Bgee | Q9NST1 | |
| CleanEx | HS_PNPLA3 | |
| ExpressionAtlas | Q9NST1 | |
| Genevestigator | Q9NST1 | |
| GO | GO:0005789 GO:0016021 GO:0016020 GO:0051265 GO:0051264 GO:0004623 GO:0004806 GO:0036155 GO:0046474 GO:0006644 GO:0044281 GO:0019432 GO:0019433 | |
| InterPro | IPR016035 IPR002641 | |
| Pfam | PF01734 | |
| SUPFAM | SSF52151 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0036153 |
triglyceride acyl-chain remodeling |
ECO:0000314 |
P |
Fig 3 |
complete | |||||
|
enables |
GO:0003841 |
1-acylglycerol-3-phosphate O-acyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005811 |
lipid droplet |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004806 |
triglyceride lipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034389 |
lipid droplet organization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006654 |
phosphatidic acid biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(CHEBI:132742) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005811 |
lipid droplet |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004806 |
triglyceride lipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:53753) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042171 |
lysophosphatidic acid acyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036042 |
long-chain fatty acyl-CoA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(CHEBI:15534)|has_direct_input:(CHEBI:15530)|has_direct_input:(CHEBI:15514)|has_direct_input:(CHEBI:15525) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001676 |
long-chain fatty acid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
|
enables |
GO:0035727 |
lysophosphatidic acid binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019433 |
triglyceride catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(CHEBI:53753) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019432 |
triglyceride biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005811 |
lipid droplet |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006650 |
glycerophospholipid metabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036153 |
triglyceride acyl-chain remodeling |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051265 |
diolein transacylation activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051264 |
mono-olein transacylation activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019433 |
triglyceride catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019432 |
triglyceride biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004806 |
triglyceride lipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004623 |
phospholipase A2 activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055088 |
lipid homeostasis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0036449 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019433 |
triglyceride catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0036449 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2151796 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005811 |
lipid droplet |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0036449 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000274414 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004806 |
triglyceride lipase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0036449 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003841 |
1-acylglycerol-3-phosphate O-acyltransferase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019433 |
triglyceride catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004806 |
triglyceride lipase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003841 |
1-acylglycerol-3-phosphate O-acyltransferase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0036155 |
acylglycerol acyl-chain remodeling |
Reactome:R-HSA-1482883 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
Reactome:R-HSA-1482811 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008654 |
phospholipid biosynthetic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005811 |
lipid droplet |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016746 |
transferase activity, transferring acyl groups |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Ruhanen, H et al. (2014) PNPLA3 mediates hepatocyte triacylglycerol remodeling. J. Lipid Res. 55 739-46 PubMed GONUTS page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Kumari, M et al. (2012) Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metab. 15 691-702 PubMed GONUTS page
- ↑ 3.0 3.1 He, S et al. (2010) A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J. Biol. Chem. 285 6706-15 PubMed GONUTS page
- ↑ 4.0 4.1 Chamoun, Z et al. (2013) PNPLA3/adiponutrin functions in lipid droplet formation. Biol. Cell 105 219-233 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Jenkins, CM et al. (2004) Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities. J. Biol. Chem. 279 48968-75 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
l
- GO:0016042 ! lipid catabolic process
- GO:0005811 ! lipid droplet
- GO:0034389 ! lipid droplet organization
- GO:0055088 ! lipid homeostasis
- GO:0006629 ! lipid metabolic process
- GO:0036042 ! long-chain fatty acyl-CoA binding
- GO:0001676 ! long-chain fatty acid metabolic process
- GO:0042171 ! lysophosphatidic acid acyltransferase activity
- GO:0035727 ! lysophosphatidic acid binding
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