GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:PLD2

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PLD2
Protein Name(s) Phospholipase D2

PLD 2 hPLD2 Choline phosphatase 2 PLD1C Phosphatidylcholine-hydrolyzing phospholipase D2

External Links
UniProt O14939
EMBL AF033850
AF035483
AF038440
AF038441
AC233723
CH471108
BC015033
BC056871
CCDS CCDS11057.1
CCDS58507.1
RefSeq NP_001230037.1
NP_002654.3
XP_006721610.1
UniGene Hs.104519
ProteinModelPortal O14939
BioGrid 111354
DIP DIP-38903N
IntAct O14939
MINT MINT-141629
STRING 9606.ENSP00000263088
BindingDB O14939
ChEMBL CHEMBL2734
DrugBank DB00122
GuidetoPHARMACOLOGY 1434
PhosphoSite O14939
MaxQB O14939
PaxDb O14939
PRIDE O14939
DNASU 5338
Ensembl ENST00000263088
ENST00000572940
GeneID 5338
KEGG hsa:5338
UCSC uc002fzc.3
uc002fzd.3
CTD 5338
GeneCards GC17P004710
H-InvDB HIX0013451
HGNC HGNC:9068
HPA HPA013397
MIM 602384
neXtProt NX_O14939
PharmGKB PA33397
eggNOG COG1502
GeneTree ENSGT00390000008356
HOGENOM HOG000246972
HOVERGEN HBG006650
InParanoid O14939
KO K01115
OMA EPSLMNG
OrthoDB EOG7N63KT
PhylomeDB O14939
TreeFam TF300589
BRENDA 3.1.4.4
Reactome REACT_120906
REACT_121280
REACT_160158
SignaLink O14939
ChiTaRS PLD2
GeneWiki PLD2
GenomeRNAi 5338
NextBio 20676
PRO PR:O14939
Proteomes UP000005640
Bgee O14939
CleanEx HS_PLD2
ExpressionAtlas O14939
Genevestigator O14939
GO GO:0031526
GO:0005789
GO:0005886
GO:0070290
GO:0035091
GO:0004630
GO:0007010
GO:0038096
GO:0002031
GO:0046474
GO:0045087
GO:0016042
GO:0006654
GO:0006655
GO:0006644
GO:0007264
GO:0044281
GO:0036465
Gene3D 2.30.29.30
3.30.1520.10
InterPro IPR001849
IPR011993
IPR001683
IPR025202
IPR001736
IPR016555
IPR015679
PANTHER PTHR18896
Pfam PF00614
PF13091
PF00787
PIRSF PIRSF009376
SMART SM00233
SM00155
SM00312
SUPFAM SSF64268
PROSITE PS50035
PS50195

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0048870

cell motility

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000431025
dictyBase:DDB_G0279483

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:21873635[1]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001051940
RGD:3350
UniProtKB:Q13393

C

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0036465

C

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001736

F

Seeded From UniProt

complete

enables

GO:0004630

phospholipase D activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016555

F

Seeded From UniProt

complete

involved_in

GO:0006654

phosphatidic acid biosynthetic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016555

P

Seeded From UniProt

complete

enables

GO:0035091

phosphatidylinositol binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001683
InterPro:IPR036871

F

Seeded From UniProt

complete

involved_in

GO:0048017

inositol lipid-mediated signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016555

P

Seeded From UniProt

complete

enables

GO:0004630

phospholipase D activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.4.4

F

Seeded From UniProt

complete

enables

GO:0070290

N-acylphosphatidylethanolamine-specific phospholipase D activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.4.4

F

Seeded From UniProt

complete

involved_in

GO:0036465

synaptic vesicle recycling

PMID:24252804[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007264

small GTPase mediated signal transduction

PMID:9582313[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007010

cytoskeleton organization

PMID:9395408[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:9395408[4]
Reactome:R-HSA-2029471

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0004630

phospholipase D activity

PMID:9582313[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

GO:0002687

positive regulation of leukocyte migration

PMID:16873675[5]

ECO:0000315

P

Figure 5D: Showed increased cell migration due to chemoattractants. Figure 5E: Showed that silencing PLD2 significantly decreased the cell migration to the chemoattractants.

complete

involved_in

GO:0038096

Fc-gamma receptor signaling pathway involved in phagocytosis

Reactome:R-HSA-2029480

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006654

phosphatidic acid biosynthetic process

Reactome:R-HSA-1483166

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

Reactome:R-HSA-1483182

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0016042

lipid catabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0442

P

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  2. ↑ Dias, V et al. (2013) The role of oxidative stress in Parkinson's disease. J Parkinsons Dis 3 461-91 PubMed GONUTS page
  3. ↑ 3.0 3.1 Lopez, I et al. (1998) Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. J. Biol. Chem. 273 12846-52 PubMed GONUTS page
  4. ↑ 4.0 4.1 Colley, WC et al. (1997) Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr. Biol. 7 191-201 PubMed GONUTS page
  5. ↑ Lehman, N et al. (2006) Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood 108 3564-72 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:PLD2&oldid=5956586"