HUMAN:PLD1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PLD1
Protein Name(s)	Phospholipase D1 PLD 1 hPLD1 Choline phosphatase 1 Phosphatidylcholine-hydrolyzing phospholipase D1
External Links
UniProt	Q13393
EMBL	U38545 BC068976 AJ276230
CCDS	CCDS3216.1 CCDS46957.1
RefSeq	NP_002653.1 XP_005247590.1 XP_005247591.1
UniGene	Hs.382865
ProteinModelPortal	Q13393
BioGrid	111353
DIP	DIP-40821N
IntAct	Q13393
MINT	MINT-141519
STRING	9606.ENSP00000342793
BindingDB	Q13393
ChEMBL	CHEMBL2536
DrugBank	DB00122
PhosphoSite	Q13393
DMDM	2499703
MaxQB	Q13393
PaxDb	Q13393
PRIDE	Q13393
DNASU	5337
Ensembl	ENST00000351298 ENST00000356327
GeneID	5337
KEGG	hsa:5337
UCSC	uc003fhs.3 uc003fht.3
CTD	5337
GeneCards	GC03M171318
HGNC	HGNC:9067
HPA	CAB004527 HPA042396
MIM	602382
neXtProt	NX_Q13393
PharmGKB	PA164742228
eggNOG	COG1502
GeneTree	ENSGT00390000008356
HOGENOM	HOG000246972
HOVERGEN	HBG006650
InParanoid	Q13393
KO	K01115
OMA	HEESIHS
OrthoDB	EOG7N63KT
PhylomeDB	Q13393
TreeFam	TF300589
BRENDA	3.1.4.4
Reactome	REACT_120906 REACT_121280 REACT_160158
SignaLink	Q13393
ChiTaRS	PLD1
GeneWiki	Phospholipase_D1
GenomeRNAi	5337
NextBio	20672
PRO	PR:Q13393
Proteomes	UP000005640
Bgee	Q13393
CleanEx	HS_PLD1
ExpressionAtlas	Q13393
Genevestigator	Q13393
GO	GO:0005789 GO:0005768 GO:0005794 GO:0000139 GO:0031902 GO:0005765 GO:0016020 GO:0048471 GO:0070290 GO:0035091 GO:0004630 GO:0006935 GO:0050830 GO:0046474 GO:0016042 GO:0006654 GO:0006655 GO:0006644 GO:0007265 GO:0007264 GO:0044281
Gene3D	2.30.29.30 3.30.1520.10
InterPro	IPR001849 IPR011993 IPR001683 IPR025202 IPR001736 IPR016555 IPR015679
PANTHER	PTHR18896
Pfam	PF00169 PF00614 PF13091 PF00787
PIRSF	PIRSF009376
SMART	SM00233 SM00155 SM00312
SUPFAM	SSF64268
PROSITE	PS50035 PS50195

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0090023	positive regulation of neutrophil chemotaxis	PMID:16873675^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Figure 1D shows the PLD1-siRNAs decreased cell migration Figure 2A shows the overexpression of PLD1 increases cell chemotaxis. Figure 3C shows that an PLD1 enzyme-inactive mutant has decreased chemotaxis when compared to wild type PLD1 activity.	complete
	GO:0031668	cellular response to extracellular stimulus	PMID:16873675^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Figure 4A: Showed PLD1 activity increased as cell migration increased with presence of chemoattractants. FIgure 4B and C: Showed how cell migration decreased in the presence of PLD1 inhibitors even in the presence of chemoattractants.	complete
part_of	GO:0016324	apical plasma membrane	PMID:22797597^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002563)	Seeded From UniProt	complete
involved_in	GO:0032534	regulation of microvillus assembly	PMID:22797597^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002563)	Seeded From UniProt	complete
part_of	GO:0030139	endocytic vesicle	PMID:22797597^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002563)	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005765	lysosomal membrane	PMID:17897319^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098981	cholinergic synapse	PMID:11752468^[5]	ECO:0006063	over expression analysis evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098981	cholinergic synapse	PMID:11752468^[5]	ECO:0006013	patch-clamp recording evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0098693	regulation of synaptic vesicle cycle	PMID:11752468^[5]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098981) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0098693	regulation of synaptic vesicle cycle	PMID:11752468^[5]	ECO:0006013	patch-clamp recording evidence used in manual assertion		P	occurs_in:(GO:0098981) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0048870	cell motility	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000431025 dictyBase:DDB_G0279483	P		Seeded From UniProt	complete
involved_in	GO:0032534	regulation of microvillus assembly	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000431049 UniProtKB:Q13393	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001051940 RGD:3350 UniProtKB:Q13393	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:14718562^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	PMID:14718562^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001736	F		Seeded From UniProt	complete
enables	GO:0004630	phospholipase D activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016555	F		Seeded From UniProt	complete
involved_in	GO:0006654	phosphatidic acid biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016555	P		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001683 InterPro:IPR036871	F		Seeded From UniProt	complete
involved_in	GO:0048017	inositol lipid-mediated signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016555	P		Seeded From UniProt	complete
enables	GO:0004630	phospholipase D activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.4.4	F		Seeded From UniProt	complete
enables	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.4.4	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8530346^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	PMID:10848592^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
	GO:0045727	positive regulation of translation	PMID:25361009^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Figure S1A shows a decrease in translation of HIF-1alpha in cells transfected with PLD1 and also subject to a PLD1 inhibitor. Figure S1E shows a decrease in translation in cells transfected with a catalytically inactive mutant PLD1.	complete CACAO 10409
involved_in	GO:0007264	small GTPase mediated signal transduction	PMID:8530346^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:10848592^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004630	phospholipase D activity	PMID:8530346^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070821	tertiary granule membrane	Reactome:R-HSA-6798747	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035579	specific granule membrane	Reactome:R-HSA-6799350	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006654	phosphatidic acid biosynthetic process	Reactome:R-HSA-1483166	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6799350 Reactome:R-HSA-6798747	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	Reactome:R-HSA-1483182	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0134	C		Seeded From UniProt	complete
part_of	GO:0031902	late endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0151	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lehman, N et al. (2006) Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood 108 3564-72 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Gloerich, M et al. (2012) Rap2A links intestinal cell polarity to brush border formation. Nat. Cell Biol. 14 793-801 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Humeau, Y et al. (2001) A role for phospholipase D1 in neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A. 98 15300-5 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 Du, G et al. (2004) Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol. Biol. Cell 15 1024-30 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Hammond, SM et al. (1995) Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J. Biol. Chem. 270 29640-3 PubMed GONUTS page
↑ ^9.0 ^9.1 Suzuki, J et al. (2000) Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts. Mol. Cell. Biol. 20 4658-65 PubMed GONUTS page
↑ Park, MH et al. (2014) Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability. Oncotarget 5 11857-72 PubMed GONUTS page

[PMID:16873675-1] 1.0 ^1.1 Lehman, N et al. (2006) Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood 108 3564-72 PubMed GONUTS page

[PMID:22797597-2] 2.0 ^2.1 ^2.2 Gloerich, M et al. (2012) Rap2A links intestinal cell polarity to brush border formation. Nat. Cell Biol. 14 793-801 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:17897319-4] Schröder, B et al. (2007) Integral and associated lysosomal membrane proteins. Traffic 8 1676-86 PubMed GONUTS page

[PMID:11752468-5] 5.0 ^5.1 ^5.2 ^5.3 Humeau, Y et al. (2001) A role for phospholipase D1 in neurotransmitter release. Proc. Natl. Acad. Sci. U.S.A. 98 15300-5 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14718562-7] 7.0 ^7.1 Du, G et al. (2004) Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol. Biol. Cell 15 1024-30 PubMed GONUTS page

[PMID:8530346-8] 8.0 ^8.1 ^8.2 Hammond, SM et al. (1995) Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J. Biol. Chem. 270 29640-3 PubMed GONUTS page

[PMID:10848592-9] 9.0 ^9.1 Suzuki, J et al. (2000) Involvement of Ras and Ral in chemotactic migration of skeletal myoblasts. Mol. Cell. Biol. 20 4658-65 PubMed GONUTS page

[PMID:25361009-10] Park, MH et al. (2014) Phospholipase D1 protein coordinates dynamic assembly of HIF-1α-PHD-VHL to regulate HIF-1α stability. Oncotarget 5 11857-72 PubMed GONUTS page

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HUMAN:PLD1

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