HUMAN:PHOP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PHOSPHO1
Protein Name(s)	Phosphoethanolamine/phosphocholine phosphatase
External Links
UniProt	Q8TCT1
EMBL	AJ457189 AC004797 BC029931 BC117187
CCDS	CCDS11547.1 CCDS45726.1
RefSeq	NP_001137276.1 NP_848595.1 XP_005257166.1
UniGene	Hs.405607
ProteinModelPortal	Q8TCT1
BioGrid	127819
STRING	9606.ENSP00000406909
ChEMBL	CHEMBL6113
DrugBank	DB00122
DEPOD	Q8TCT1
PhosphoSite	Q8TCT1
DMDM	74715842
PaxDb	Q8TCT1
PRIDE	Q8TCT1
Ensembl	ENST00000310544 ENST00000413580 ENST00000514112
GeneID	162466
KEGG	hsa:162466
UCSC	uc002ios.2 uc010wlv.1
CTD	162466
GeneCards	GC17M047300
HGNC	HGNC:16815
HPA	HPA053016
neXtProt	NX_Q8TCT1
PharmGKB	PA33276
eggNOG	NOG331523
GeneTree	ENSGT00390000007741
HOGENOM	HOG000231038
HOVERGEN	HBG080058
InParanoid	Q8TCT1
KO	K06124
OMA	QQVLKSC
OrthoDB	EOG7BZVTZ
PhylomeDB	Q8TCT1
TreeFam	TF300112
BioCyc	MetaCyc:HS16266-MONOMER
BRENDA	3.1.3.75
Reactome	REACT_120919 REACT_121238
GenomeRNAi	162466
NextBio	88177
PRO	PR:Q8TCT1
Proteomes	UP000005640
Bgee	Q8TCT1
CleanEx	HS_PHOSPHO1
ExpressionAtlas	Q8TCT1
Genevestigator	Q8TCT1
GO	GO:0005829 GO:0046872 GO:0052731 GO:0052732 GO:0016462 GO:0035630 GO:0016311 GO:0001958 GO:0046474 GO:0006656 GO:0006646 GO:0006644 GO:0030500 GO:0044281
Gene3D	3.40.50.1000
InterPro	IPR023214 IPR006383 IPR016965 IPR006384
Pfam	PF06888
PIRSF	PIRSF031051
SUPFAM	SSF56784
TIGRFAMs	TIGR01489 TIGR01488

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0035630	bone mineralization involved in bone maturation		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2447348 PANTHER:PTN000467159	P		Seeded From UniProt	complete
	GO:0044606	phosphocholine hydrolase activity	PMID:24225136	ECO:0000314			F		Figure 1 shows some of the human phosphocholine hydrolase enzymes and the correlation between various cytotoxic t cell lines and apoptosis. Without the phosphocholine hydrolase activity of these enzymes, apoptosis wouldn't be induced and there would be no reduction in percent survival.	complete CACAO 10117
enables	GO:0016462	pyrophosphatase activity	PMID:19874193	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016791	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0052732	P		Seeded From UniProt	complete
part_of	GO:0065010	extracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R2H9 ensembl:ENSMUSP00000057858	C		Seeded From UniProt	complete
involved_in	GO:0035630	bone mineralization involved in bone maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R2H9 ensembl:ENSMUSP00000057858	P		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R2H9 ensembl:ENSMUSP00000057858	C		Seeded From UniProt	complete
involved_in	GO:0001958	endochondral ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8R2H9 ensembl:ENSMUSP00000057858	P		Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006384 InterPro:IPR016965	F		Seeded From UniProt	complete
enables	GO:0052732	phosphoethanolamine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.75	F		Seeded From UniProt	complete
enables	GO:0052731	phosphocholine phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.75	F		Seeded From UniProt	complete
involved_in	GO:0006656	phosphatidylcholine biosynthetic process	Reactome:R-HSA-1483191	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006646	phosphatidylethanolamine biosynthetic process	Reactome:R-HSA-1483213	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-1483159 Reactome:R-HSA-1483096	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0030500	regulation of bone mineralization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0495	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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References

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