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HUMAN:PGS2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) DCN (synonyms: SLRR1B)
Protein Name(s) Decorin

Bone proteoglycan II PG-S2 PG40

External Links
UniProt P07585
EMBL M14219
L01131
L01125
L01126
L01127
L01129
L01130
AH005442
AF138300
AF138301
AF138302
AF138303
AF138304
BT019800
AF491944
BC005322
CCDS CCDS44951.1
CCDS9039.1
CCDS9040.1
CCDS9041.1
CCDS9042.1
PIR A45016
B28457
RefSeq NP_001911.1
NP_598010.1
NP_598011.1
NP_598012.1
NP_598013.1
NP_598014.1
XP_005268750.1
XP_006719333.1
UniGene Hs.156316
ProteinModelPortal P07585
SMR P07585
BioGrid 108002
IntAct P07585
STRING 9606.ENSP00000052754
PhosphoSite P07585
DMDM 129951
PaxDb P07585
PRIDE P07585
DNASU 1634
Ensembl ENST00000052754
ENST00000393155
ENST00000420120
ENST00000425043
ENST00000441303
ENST00000456569
ENST00000547568
ENST00000552962
GeneID 1634
KEGG hsa:1634
UCSC uc001tbo.3
uc001tbp.3
uc001tbq.3
uc001tbr.3
uc001tbt.3
CTD 1634
GeneCards GC12M091472
GeneReviews DCN
HGNC HGNC:2705
HPA CAB017118
HPA003315
MIM 125255
610048
neXtProt NX_P07585
Orphanet 101068
PharmGKB PA27177
eggNOG COG4886
GeneTree ENSGT00760000118969
HOGENOM HOG000261690
HOVERGEN HBG016052
InParanoid P07585
KO K04660
OMA PLGPVCP
OrthoDB EOG76739V
PhylomeDB P07585
TreeFam TF334562
Reactome REACT_118572
REACT_120800
REACT_120888
REACT_120989
REACT_121408
REACT_163906
REACT_267642
REACT_267659
REACT_267682
REACT_267708
REACT_267711
ChiTaRS DCN
GeneWiki Decorin
GenomeRNAi 1634
NextBio 6702
PMAP-CutDB P07585
PRO PR:P07585
Proteomes UP000005640
Bgee P07585
CleanEx HS_DCN
ExpressionAtlas P07585
Genevestigator P07585
GO GO:0005589
GO:0005576
GO:0005615
GO:0005796
GO:0043202
GO:0005578
GO:0050840
GO:0005539
GO:0044822
GO:0007568
GO:0005975
GO:0030206
GO:0030207
GO:0030204
GO:0030208
GO:0022617
GO:0030198
GO:0030203
GO:0001822
GO:0009887
GO:0019800
GO:0001890
GO:0032496
GO:0009612
GO:0007519
GO:0044281
GO:0042060
InterPro IPR028549
IPR001611
IPR003591
IPR000372
IPR016352
PANTHER PTHR24369:SF5
Pfam PF13855
PF01462
PIRSF PIRSF002490
SMART SM00369
SM00013
PROSITE PS51450

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0010508

positive regulation of autophagy

PMID:23798385[1]

ECO:0000314

P

Figure 2

complete
CACAO 10203

enables

GO:0030021

extracellular matrix structural constituent conferring compression resistance

PMID:28327460[2]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(CL:0002540)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28327460[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002540)

Seeded From UniProt

complete

enables

GO:0030021

extracellular matrix structural constituent conferring compression resistance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9XSD9

F

occurs_in:(UBERON:0002084)

Seeded From UniProt

complete

enables

GO:0030021

extracellular matrix structural constituent conferring compression resistance

PMID:20551380[3]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0001496)

Seeded From UniProt

complete

enables

GO:0030021

extracellular matrix structural constituent conferring compression resistance

PMID:27559042[4]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

  • occurs_in:(UBERON:0006618)
  • occurs_in:(UBERON:0002302)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28675934[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0003688)|part_of:(UBERON:0001911)

Seeded From UniProt

complete

enables

GO:0030021

extracellular matrix structural constituent conferring compression resistance

PMID:28675934[5]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0003688)|occurs_in:(UBERON:0001911)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0002107)

Seeded From UniProt

complete

enables

GO:0030021

extracellular matrix structural constituent conferring compression resistance

PMID:25037231[6]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0001155)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:25037231[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001155)

Seeded From UniProt

complete

enables

GO:0030021

extracellular matrix structural constituent conferring compression resistance

PMID:25037231[6]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0002107)

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:27068509[7]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27559042[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0006618)
  • part_of:(UBERON:0002302)

Seeded From UniProt

complete

involved_in

GO:0010508

positive regulation of autophagy

PMID:23798385[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:20551380[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001496)

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:22261194[8]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9XSD9

C

part_of:(UBERON:0002084)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:20551380[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001496)

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[9]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1900747

negative regulation of vascular endothelial growth factor signaling pathway

PMID:23798385[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090141

positive regulation of mitochondrial fission

PMID:23798385[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P35968

P

Seeded From UniProt

complete

involved_in

GO:0051901

positive regulation of mitochondrial depolarization

PMID:23798385[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P35968

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:23798385[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:Q3URU2

P

Seeded From UniProt

complete

involved_in

GO:0016525

negative regulation of angiogenesis

PMID:23978385[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:23798385[1]

ECO:0000316

genetic interaction evidence used in manual assertion

UniProtKB:P35968

P

Seeded From UniProt

complete

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:23798385[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:23798385[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010596

negative regulation of endothelial cell migration

PMID:23798385[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0050840

extracellular matrix binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28654
ensembl:ENSMUSP00000100924

F

Seeded From UniProt

complete

involved_in

GO:0019800

peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28654
ensembl:ENSMUSP00000100924

P

Seeded From UniProt

complete

enables

GO:0005539

glycosaminoglycan binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P28654
ensembl:ENSMUSP00000100924

F

Seeded From UniProt

complete

enables

GO:0047485

protein N-terminus binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

F

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

C

Seeded From UniProt

complete

involved_in

GO:0009612

response to mechanical stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

P

Seeded From UniProt

complete

involved_in

GO:0007519

skeletal muscle tissue development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

P

Seeded From UniProt

complete

part_of

GO:0005589

collagen type VI trimer

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

C

Seeded From UniProt

complete

enables

GO:0005518

collagen binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

F

Seeded From UniProt

complete

involved_in

GO:0001890

placenta development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

P

Seeded From UniProt

complete

involved_in

GO:0001822

kidney development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q01129
ensembl:ENSRNOP00000006070

P

Seeded From UniProt

complete

enables

GO:0005518

collagen binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR028549

F

Seeded From UniProt

complete

involved_in

GO:0009887

animal organ morphogenesis

PMID:7961765[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043202

lysosomal lumen

Reactome:R-HSA-2065233
Reactome:R-HSA-2022056
Reactome:R-HSA-1793176

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0030208

dermatan sulfate biosynthetic process

Reactome:R-HSA-2022923

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030207

chondroitin sulfate catabolic process

Reactome:R-HSA-2024101

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030206

chondroitin sulfate biosynthetic process

Reactome:R-HSA-2022870

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

Reactome:R-HSA-1474244

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

Reactome:R-HSA-4420365
Reactome:R-HSA-3636919
Reactome:R-HSA-3595178
Reactome:R-HSA-3595176
Reactome:R-HSA-3595175
Reactome:R-HSA-3560804
Reactome:R-HSA-3560802
Reactome:R-HSA-2022911
Reactome:R-HSA-2022065
Reactome:R-HSA-2022063
Reactome:R-HSA-2022061
Reactome:R-HSA-2022052
Reactome:R-HSA-2018682
Reactome:R-HSA-2018659
Reactome:R-HSA-1971491
Reactome:R-HSA-1971487
Reactome:R-HSA-1971483
Reactome:R-HSA-1971482
Reactome:R-HSA-1889981
Reactome:R-HSA-1889978
Reactome:R-HSA-1889955
Reactome:R-HSA-1878002

ECO:0000304

author statement supported by traceable reference used in manual assertion






















C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-NUL-2466133
Reactome:R-HSA-3828025
Reactome:R-HSA-2534248
Reactome:R-HSA-2327909
Reactome:R-HSA-2022911
Reactome:R-HSA-2022065
Reactome:R-HSA-2022056

ECO:0000304

author statement supported by traceable reference used in manual assertion







C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Buraschi, S et al. (2013) Decorin causes autophagy in endothelial cells via Peg3. Proc. Natl. Acad. Sci. U.S.A. 110 E2582-91 PubMed GONUTS page
  2. ↑ 2.0 2.1 Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Barallobre-Barreiro, J et al. (2016) Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation. Circulation 134 817-32 PubMed GONUTS page
  5. ↑ 5.0 5.1 Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Naba, A et al. (2014) Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. BMC Cancer 14 518 PubMed GONUTS page
  7. ↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  8. ↑ Barallobre-Barreiro, J et al. (2012) Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. Circulation 125 789-802 PubMed GONUTS page
  9. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  10. ↑ Gornstein, E & Schwarz, TL (2014) The paradox of paclitaxel neurotoxicity: Mechanisms and unanswered questions. Neuropharmacology 76 Pt A 175-83 PubMed GONUTS page
  11. ↑ Scholzen, T et al. (1994) The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation. J. Biol. Chem. 269 28270-81 PubMed GONUTS page
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