HUMAN:PGK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PGK1 (synonyms: PGKA)
Protein Name(s)	Phosphoglycerate kinase 1 Cell migration-inducing gene 10 protein Primer recognition protein 2 PRP 2
External Links
UniProt	P00558
EMBL	V00572 L00160 M11968 M11958 M11959 M11960 M11961 M11962 M11963 M11964 M11965 M11966 M11967 AY423725 AB062432 AK291081 AK301740 AK312280 CR456716 AL049589 CH471104 BC023234 BC103752 BC104837 BC113568 M34017
CCDS	CCDS14438.1
PIR	I59050
RefSeq	NP_000282.1
UniGene	Hs.78771
PDB	2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C 3ZOZ 4AXX 4O33
PDBsum	2WZB 2WZC 2WZD 2X13 2X14 2X15 2XE6 2XE7 2XE8 2Y3I 2YBE 2ZGV 3C39 3C3A 3C3B 3C3C 3ZOZ 4AXX 4O33
ProteinModelPortal	P00558
SMR	P00558
BioGrid	111251
DIP	DIP-33679N
IntAct	P00558
MINT	MINT-1131047
STRING	9606.ENSP00000362413
ChEMBL	CHEMBL2096677
DrugBank	DB00709
iPTMnet	P00558
PhosphoSite	P00558
SwissPalm	P00558
BioMuta	PGK1
DMDM	52788229
DOSAC-COBS-2DPAGE	P00558
OGP	P00558
REPRODUCTION-2DPAGE	IPI00169383 P00558
UCD-2DPAGE	P00558
EPD	P00558
PaxDb	P00558
PeptideAtlas	P00558
PRIDE	P00558
TopDownProteomics	P00558-1
DNASU	5230
Ensembl	ENST00000373316
GeneID	5230
KEGG	hsa:5230
CTD	5230
GeneCards	PGK1
HGNC	HGNC:8896
HPA	CAB010065 HPA045385
MalaCards	PGK1
MIM	300653 311800
neXtProt	NX_P00558
Orphanet	713
PharmGKB	PA33234
eggNOG	KOG1367 COG0126
HOGENOM	HOG000227107
HOVERGEN	HBG008177
InParanoid	P00558
KO	K00927
OMA	KATARGC
OrthoDB	EOG74R1QN
PhylomeDB	P00558
TreeFam	TF300489
BioCyc	MetaCyc:HS02359-MONOMER
Reactome	R-HSA-70171 R-HSA-70263
SABIO-RK	P00558
UniPathway	UPA00109
ChiTaRS	PGK1
EvolutionaryTrace	P00558
GeneWiki	PGK1
GenomeRNAi	5230
NextBio	20218
PRO	PR:P00558
Proteomes	UP000005640
Bgee	P00558
CleanEx	HS_PGK1
ExpressionAtlas	P00558
Genevisible	P00558
GO	GO:0005829 GO:0070062 GO:0016020 GO:0045121 GO:0005524 GO:0004618 GO:0061621 GO:0005975 GO:0030855 GO:0006094 GO:0006006 GO:0016310 GO:0044281
Gene3D	3.40.50.1260 3.40.50.1270
HAMAP	MF_00145
InterPro	IPR001576 IPR015901 IPR015911 IPR015824
PANTHER	PTHR11406
Pfam	PF00162
PIRSF	PIRSF000724
PRINTS	PR00477
SUPFAM	SSF53748
PROSITE	PS00111

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005739	mitochondrion	PMID:26942675^[1]	ECO:0000314			C		Cell fractionation shows that cytosolic PGK1 translocates to the mitochondria in response to hypoxia (Figure S1B).	complete CACAO 11437
enables	GO:0004618	phosphoglycerate kinase activity	PMID:7391028^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:7391028^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11130727^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:11130727^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	PMID:11130727^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0031639)	Seeded From UniProt	complete
enables	GO:0047134	protein-disulfide reductase activity	PMID:11130727^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:P00747) part_of:(GO:0031639)	Seeded From UniProt	complete
involved_in	GO:0031639	plasminogen activation	PMID:11130727^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:25204797^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002618)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:11487543^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002563)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:0030855	epithelial cell differentiation	PMID:21492153^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P	results_in_acquisition_of_features_of:(CL:1000334)	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41759	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00559	F		Seeded From UniProt	complete
enables	GO:0004618	phosphoglycerate kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P41759	F		Seeded From UniProt	complete
involved_in	GO:1903862	positive regulation of oxidative phosphorylation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000150497 ZFIN:ZDB-GENE-040426-2711	P		Seeded From UniProt	complete
enables	GO:0043531	ADP binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000150497 RGD:619878	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10703 MGI:MGI:97555 MGI:MGI:97563 PANTHER:PTN000150497 RGD:619878 SGD:S000000605 TAIR:locus:2206410 UniProtKB:P00558 UniProtKB:P50318	P		Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000150497 RGD:619878 SGD:S000000605	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10703 PANTHER:PTN000150497 RGD:619878 TAIR:locus:2087750 TAIR:locus:2206410	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000150497 RGD:619878 UniProtKB:P00559	F		Seeded From UniProt	complete
enables	GO:0004618	phosphoglycerate kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10703 MGI:MGI:97555 MGI:MGI:97563 PANTHER:PTN000150497 RGD:619878 SGD:S000000605 UniProtKB:P00558 UniProtKB:P11977	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09411 ensembl:ENSMUSP00000080302	P		Seeded From UniProt	complete
enables	GO:0004618	phosphoglycerate kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09411 ensembl:ENSMUSP00000080302	F		Seeded From UniProt	complete
enables	GO:0004618	phosphoglycerate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001576 InterPro:IPR015824 InterPro:IPR015911 InterPro:IPR036043	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001576 InterPro:IPR015824 InterPro:IPR015911 InterPro:IPR036043	P		Seeded From UniProt	complete
enables	GO:0004618	phosphoglycerate kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.2.3	F		Seeded From UniProt	complete
involved_in	GO:0061621	canonical glycolysis	Reactome:R-HSA-70171	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006094	gluconeogenesis	Reactome:R-HSA-70263	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-71850 Reactome:R-HSA-70486	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037 GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324 UniPathway:UPA00109	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Li, X et al. (2016) Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Mol. Cell 61 705-19 PubMed GONUTS page
↑ ^2.0 ^2.1 Fujii, H et al. (1980) A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK München) associated with enzyme deficiency. J. Biol. Chem. 255 6421-3 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Lay, AJ et al. (2000) Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase. Nature 408 869-73 PubMed GONUTS page
↑ Fork, C et al. (2014) Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res. Cardiol. 109 439 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ van Niel, G et al. (2001) Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 121 337-49 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ Buhrke, T et al. (2011) Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Dev. Growth Differ. 53 411-26 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26942675-1] Li, X et al. (2016) Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Mol. Cell 61 705-19 PubMed GONUTS page

[PMID:7391028-2] 2.0 ^2.1 Fujii, H et al. (1980) A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK München) associated with enzyme deficiency. J. Biol. Chem. 255 6421-3 PubMed GONUTS page

[PMID:11130727-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Lay, AJ et al. (2000) Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase. Nature 408 869-73 PubMed GONUTS page

[PMID:25204797-4] Fork, C et al. (2014) Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res. Cardiol. 109 439 PubMed GONUTS page

[PMID:23533145-5] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19946888-6] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19199708-7] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:11487543-8] van Niel, G et al. (2001) Intestinal epithelial cells secrete exosome-like vesicles. Gastroenterology 121 337-49 PubMed GONUTS page

[PMID:20458337-9] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:21492153-10] Buhrke, T et al. (2011) Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2. Dev. Growth Differ. 53 411-26 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:PGK1

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