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HUMAN:PGCA

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) ACAN (synonyms: AGC1, CSPG1, MSK16)
Protein Name(s) Aggrecan core protein

Cartilage-specific proteoglycan core protein CSPCP Chondroitin sulfate proteoglycan core protein 1 Chondroitin sulfate proteoglycan 1 Aggrecan core protein 2

External Links
UniProt P16112
EMBL M55172
X80278
S74659
X17406
J05062
PIR A39086
UniGene Hs.2159
Hs.616395
PDB 4MD4
PDBsum 4MD4
ProteinModelPortal P16112
SMR P16112
IntAct P16112
STRING 9606.ENSP00000268134
PhosphoSite P16112
DMDM 129886
PaxDb P16112
PRIDE P16112
GeneCards GC15P089346
H-InvDB HIX0026812
HGNC HGNC:319
HPA CAB016377
MIM 155760
165800
608361
612813
neXtProt NX_P16112
Orphanet 251262
171866
93283
PharmGKB PA24616
eggNOG NOG12793
HOGENOM HOG000168421
HOVERGEN HBG007982
InParanoid P16112
PhylomeDB P16112
Reactome REACT_118572
REACT_121120
REACT_121313
REACT_163906
REACT_267635
REACT_267713
ChiTaRS ACAN
PMAP-CutDB P16112
PRO PR:P16112
Proteomes UP000005640
CleanEx HS_ACAN
Genevestigator P16112
GO GO:0005576
GO:0005796
GO:0043202
GO:0005578
GO:0030246
GO:0005201
GO:0005540
GO:0046872
GO:0005975
GO:0007155
GO:0022617
GO:0030198
GO:0030203
GO:0018146
GO:0042340
GO:0042339
GO:0006508
GO:0001501
GO:0044281
Gene3D 2.60.40.10
3.10.100.10
InterPro IPR001304
IPR016186
IPR018378
IPR016187
IPR000742
IPR013032
IPR007110
IPR013783
IPR003006
IPR003599
IPR013106
IPR000538
IPR000436
Pfam PF00008
PF00059
PF00084
PF07686
PF00193
PRINTS PR01265
SMART SM00032
SM00034
SM00181
SM00409
SM00445
SUPFAM SSF56436
SSF57535
PROSITE PS00615
PS50041
PS00022
PS01186
PS50026
PS50835
PS00290
PS01241
PS50963
PS50923

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0030021

extracellular matrix structural constituent conferring compression resistance

PMID:27068509[1]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0007318)

Seeded From UniProt

complete

enables

GO:0030021

extracellular matrix structural constituent conferring compression resistance

PMID:20551380[2]

ECO:0007666

automatically integrated combinatorial computational and experimental evidence used in manual assertion

F

occurs_in:(UBERON:0001496)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27068509[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:20551380[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001496)

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:1569188[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

PMID:1569188[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102889
MGI:MGI:1096385
MGI:MGI:1337006
MGI:MGI:2137300
MGI:MGI:99602
PANTHER:PTN001105676

C

Seeded From UniProt

complete

involved_in

GO:0007417

central nervous system development

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001105676
RGD:68358

P

Seeded From UniProt

complete

involved_in

GO:0001501

skeletal system development

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001105676
ZFIN:ZDB-GENE-030131-2185

P

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

C

Seeded From UniProt

complete

part_of

GO:0098966

perisynaptic extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

C

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

C

Seeded From UniProt

complete

involved_in

GO:0030199

collagen fibril organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

P

Seeded From UniProt

complete

involved_in

GO:0030166

proteoglycan biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

P

Seeded From UniProt

complete

involved_in

GO:0007507

heart development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

P

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

C

Seeded From UniProt

complete

involved_in

GO:0002063

chondrocyte development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

P

Seeded From UniProt

complete

involved_in

GO:0001502

cartilage condensation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61282
ensembl:ENSMUSP00000032835

P

Seeded From UniProt

complete

enables

GO:0005540

hyaluronic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000538

F

Seeded From UniProt

complete

involved_in

GO:0007155

cell adhesion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000538

P

Seeded From UniProt

complete

enables

GO:0005201

extracellular matrix structural constituent

PMID:1569188[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0043202

lysosomal lumen

Reactome:R-HSA-2046239
Reactome:R-HSA-1793217

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0042340

keratan sulfate catabolic process

Reactome:R-HSA-2022857

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

Reactome:R-HSA-1474244

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018146

keratan sulfate biosynthetic process

Reactome:R-HSA-2022854

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005796

Golgi lumen

Reactome:R-HSA-9035950
Reactome:R-HSA-9035949
Reactome:R-HSA-3656269
Reactome:R-HSA-3656258
Reactome:R-HSA-3656230
Reactome:R-HSA-2046298
Reactome:R-HSA-2046285
Reactome:R-HSA-2046265
Reactome:R-HSA-2046222
Reactome:R-HSA-2046180
Reactome:R-HSA-2046175
Reactome:R-HSA-2025724
Reactome:R-HSA-2025723

ECO:0000304

author statement supported by traceable reference used in manual assertion













C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-8855825
Reactome:R-HSA-2424252
Reactome:R-HSA-2424246
Reactome:R-HSA-2318623
Reactome:R-HSA-2046239
Reactome:R-HSA-2046180

ECO:0000304

author statement supported by traceable reference used in manual assertion






C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0430

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  2. ↑ 2.0 2.1 Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Sandy, JD et al. (1992) The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain. J. Clin. Invest. 89 1512-6 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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