HUMAN:PGAM5

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PGAM5
Protein Name(s)	Serine/threonine-protein phosphatase PGAM5, mitochondrial Bcl-XL-binding protein v68 Phosphoglycerate mutase family member 5
External Links
UniProt	Q96HS1
EMBL	EU249757 AC135586 BC008196 AF357523
CCDS	CCDS53845.1 CCDS9280.1
RefSeq	NP_001164014.1 NP_612642.2
UniGene	Hs.102558
PDB	3MXO 3O0T
PDBsum	3MXO 3O0T
ProteinModelPortal	Q96HS1
SMR	Q96HS1
BioGrid	128154
DIP	DIP-50735N
IntAct	Q96HS1
MINT	MINT-1385191
DEPOD	Q96HS1
PhosphoSite	Q96HS1
DMDM	150417955
MaxQB	Q96HS1
PaxDb	Q96HS1
PRIDE	Q96HS1
Ensembl	ENST00000317555 ENST00000498926
GeneID	192111
KEGG	hsa:192111
UCSC	uc001uku.3 uc009zyv.3
CTD	192111
GeneCards	GC12P133287
H-InvDB	HIX0017319
HGNC	HGNC:28763
HPA	HPA036978 HPA036979
MIM	614939
neXtProt	NX_Q96HS1
PharmGKB	PA143485574
eggNOG	NOG71348
GeneTree	ENSGT00390000004796
HOGENOM	HOG000261217
HOVERGEN	HBG105576
InParanoid	Q96HS1
KO	K15637
OMA	EIIVCHA
OrthoDB	EOG7966H1
PhylomeDB	Q96HS1
TreeFam	TF314977
ChiTaRS	PGAM5
EvolutionaryTrace	Q96HS1
GenomeRNAi	192111
NextBio	89319
PRO	PR:Q96HS1
Proteomes	UP000005640
Bgee	Q96HS1
CleanEx	HS_PGAM5
ExpressionAtlas	Q96HS1
Genevestigator	Q96HS1
GO	GO:0016021 GO:0005741 GO:0005739 GO:0005096 GO:0016791 GO:0004721 GO:0032403 GO:0016311 GO:0070266 GO:0043547
Gene3D	3.40.50.1240
InterPro	IPR013078 IPR029033
Pfam	PF00300
SMART	SM00855
SUPFAM	SSF53254

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004722	protein serine/threonine phosphatase activity	PMID:19590015^[1]	ECO:0000314			F		Fig 4C	complete CACAO 2316
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:27077115^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8BX10	P		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	PMID:19590015^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	PMID:22265414^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q96HS1-1) has_direct_input:(UniProtKB:Q96HS1-2)	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:22265414^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q13546) has_direct_input:(UniProtKB:Q8NB16) has_direct_input:(UniProtKB:Q9Y572) happens_during:(GO:0070266)	Seeded From UniProt	complete
enables	GO:0016791	phosphatase activity	PMID:22265414^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:O00429) happens_during:(GO:0070266)	Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	PMID:22265414^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:O00429) happens_during:(GO:0070266)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004722	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004722	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004721	P		Seeded From UniProt	complete
involved_in	GO:0016311	dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0016791	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BX10 ensembl:ENSMUSP00000108124	P		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8BX10 ensembl:ENSMUSP00000108124	P		Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.3.16	F		Seeded From UniProt	complete
involved_in	GO:0016236	macroautophagy	Reactome:R-HSA-8934903	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	Reactome:R-HSA-8948139	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004722	protein serine/threonine phosphatase activity	Reactome:R-HSA-8948139	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1210	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Takeda, K et al. (2009) Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Proc. Natl. Acad. Sci. U.S.A. 106 12301-5 PubMed GONUTS page
↑ Sekine, S et al. (2016) The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress. EBioMedicine 5 82-92 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Wang, Z et al. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148 228-43 PubMed GONUTS page

[PMID:19590015-1] 1.0 ^1.1 Takeda, K et al. (2009) Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Proc. Natl. Acad. Sci. U.S.A. 106 12301-5 PubMed GONUTS page

[PMID:27077115-2] Sekine, S et al. (2016) The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress. EBioMedicine 5 82-92 PubMed GONUTS page

[PMID:22265414-3] 3.0 ^3.1 ^3.2 ^3.3 Wang, Z et al. (2012) The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 148 228-43 PubMed GONUTS page

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HUMAN:PGAM5

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