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HUMAN:PDIA6

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PDIA6 (synonyms: ERP5, P5, TXNDC7)
Protein Name(s) Protein disulfide-isomerase A6

Endoplasmic reticulum protein 5 ER protein 5 ERp5 Protein disulfide isomerase P5 Thioredoxin domain-containing protein 7

External Links
UniProt Q15084
EMBL D49489
AK127433
AK131234
AK289428
AK294347
AK297547
AC092687
CH471053
BC001312
U79278
CCDS CCDS1675.1
CCDS62852.1
CCDS62853.1
CCDS62854.1
CCDS62855.1
PIR JC4369
RefSeq NP_001269633.1
NP_001269634.1
NP_001269635.1
NP_001269636.1
NP_005733.1
UniGene Hs.212102
Hs.580464
PDB 1X5D
3VWW
3W8J
4EF0
4GWR
PDBsum 1X5D
3VWW
3W8J
4EF0
4GWR
ProteinModelPortal Q15084
SMR Q15084
BioGrid 115434
IntAct Q15084
MINT MINT-3030897
STRING 9606.ENSP00000272227
ChEMBL CHEMBL2146308
PhosphoSite Q15084
DMDM 2501205
OGP Q15084
REPRODUCTION-2DPAGE IPI00644989
Q15084
MaxQB Q15084
PaxDb Q15084
PRIDE Q15084
DNASU 10130
Ensembl ENST00000272227
ENST00000381611
ENST00000404371
ENST00000404824
ENST00000540494
ENST00000617249
GeneID 10130
KEGG hsa:10130
UCSC uc002rau.3
uc002rav.3
CTD 10130
GeneCards GC02M010923
HGNC HGNC:30168
HPA HPA034652
HPA034653
MIM 611099
neXtProt NX_Q15084
PharmGKB PA134977905
eggNOG COG0526
GeneTree ENSGT00730000110455
HOGENOM HOG000012631
HOVERGEN HBG053548
InParanoid Q15084
KO K09584
OMA KNLEPEW
OrthoDB EOG7XDBFV
PhylomeDB Q15084
TreeFam TF315231
Reactome REACT_18273
ChiTaRS PDIA6
EvolutionaryTrace Q15084
GenomeRNAi 10130
NextBio 35470712
PRO PR:Q15084
Proteomes UP000005640
Bgee Q15084
CleanEx HS_PDIA6
Genevestigator Q15084
GO GO:0005783
GO:0005788
GO:0005789
GO:0005793
GO:0070062
GO:0042470
GO:0005886
GO:0005790
GO:0003756
GO:0006987
GO:0043277
GO:0045454
GO:0044267
GO:0030968
GO:0006457
GO:0034976
Gene3D 3.40.30.10
InterPro IPR005788
IPR012336
IPR017937
IPR013766
Pfam PF00085
SUPFAM SSF52833
TIGRFAMs TIGR01126
PROSITE PS00014
PS00194
PS51352

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006457

protein folding

PMID:23142642[1]

ECO:0000314

P

Confirmed with a MYTH screen of human adult brain cDNA library, Table 1 shows the function of PDIA6 in protein folding.

complete
CACAO 5768

part_of

GO:0034663

endoplasmic reticulum chaperone complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q922R8

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

enables

GO:0015037

peptide disulfide oxidoreductase activity

PMID:16677074[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:19995400[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005793

endoplasmic reticulum-Golgi intermediate compartment

PMID:15308636[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0015037

P

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR005788

F

Seeded From UniProt

complete

involved_in

GO:0045454

cell redox homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR013766
InterPro:IPR017937

P

Seeded From UniProt

complete

enables

GO:0003756

protein disulfide isomerase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:5.3.4.1

F

Seeded From UniProt

complete

involved_in

GO:0006457

protein folding

PMID:7590364[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003756

protein disulfide isomerase activity

PMID:7590364[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:16130169[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0044267

cellular protein metabolic process

Reactome:R-HSA-392499

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043687

post-translational protein modification

Reactome:R-HSA-597592

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0036498

IRE1-mediated unfolded protein response

Reactome:R-HSA-381070

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

Reactome:R-HSA-1791131

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

Reactome:R-HSA-8952289

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0016853

isomerase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0413

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0256

C

Seeded From UniProt

complete

part_of

GO:0042470

melanosome

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0161

C

Seeded From UniProt

complete

part_of

GO:0005788

endoplasmic reticulum lumen

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0096

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Passantino, R et al. (2013) Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. Biochim. Biophys. Acta 1833 529-40 PubMed GONUTS page
  2. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  3. ↑ Alanen, HI et al. () pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family. Antioxid. Redox Signal. 8 283-91 PubMed GONUTS page
  4. ↑ Holbrook, LM et al. (2010) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br. J. Haematol. 148 627-37 PubMed GONUTS page
  5. ↑ Breuza, L et al. (2004) Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. J. Biol. Chem. 279 47242-53 PubMed GONUTS page
  6. ↑ 6.0 6.1 Hayano, T & Kikuchi, M (1995) Cloning and sequencing of the cDNA encoding human P5. Gene 164 377-8 PubMed GONUTS page
  7. ↑ Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page
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