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HUMAN:PDIA4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | PDIA4 (synonyms: ERP70, ERP72) | |
| Protein Name(s) | Protein disulfide-isomerase A4
Endoplasmic reticulum resident protein 70 ER protein 70 ERp70 Endoplasmic reticulum resident protein 72 ER protein 72 ERp-72 ERp72 | |
| External Links | ||
| UniProt | P13667 | |
| EMBL | J05016 AK290971 AC093743 CH471146 CH471146 BC000425 BC001928 BC006344 BC011754 | |
| CCDS | CCDS5893.1 | |
| PIR | A23723 | |
| RefSeq | NP_004902.1 | |
| UniGene | Hs.93659 | |
| PDB | 3IDV | |
| PDBsum | 3IDV | |
| ProteinModelPortal | P13667 | |
| SMR | P13667 | |
| BioGrid | 114966 | |
| IntAct | P13667 | |
| MINT | MINT-4999858 | |
| STRING | 9606.ENSP00000286091 | |
| PhosphoSite | P13667 | |
| DMDM | 119530 | |
| OGP | P13667 | |
| REPRODUCTION-2DPAGE | IPI00009904 | |
| MaxQB | P13667 | |
| PaxDb | P13667 | |
| PeptideAtlas | P13667 | |
| PRIDE | P13667 | |
| DNASU | 9601 | |
| Ensembl | ENST00000286091 | |
| GeneID | 9601 | |
| KEGG | hsa:9601 | |
| UCSC | uc003wff.2 | |
| CTD | 9601 | |
| GeneCards | GC07M148700 | |
| HGNC | HGNC:30167 | |
| HPA | CAB017368 HPA006139 HPA006140 | |
| neXtProt | NX_P13667 | |
| PharmGKB | PA142671190 | |
| eggNOG | COG0526 | |
| GeneTree | ENSGT00760000119201 | |
| HOGENOM | HOG000162459 | |
| HOVERGEN | HBG005920 | |
| InParanoid | P13667 | |
| KO | K09582 | |
| OMA | IIGVFKG | |
| OrthoDB | EOG7VHSX1 | |
| PhylomeDB | P13667 | |
| TreeFam | TF106382 | |
| BRENDA | 5.3.4.1 | |
| ChiTaRS | PDIA4 | |
| EvolutionaryTrace | P13667 | |
| GenomeRNAi | 9601 | |
| NextBio | 36019 | |
| PRO | PR:P13667 | |
| Proteomes | UP000005640 | |
| Bgee | P13667 | |
| CleanEx | HS_PDIA4 | |
| ExpressionAtlas | P13667 | |
| Genevestigator | P13667 | |
| GO | GO:0009986 GO:0005783 GO:0005788 GO:0042470 GO:0044822 GO:0003756 GO:0045454 GO:0061077 GO:0006457 GO:0009306 GO:0034976 | |
| Gene3D | 3.40.30.10 | |
| InterPro | IPR005788 IPR005792 IPR017068 IPR012336 IPR017937 IPR013766 | |
| Pfam | PF00085 | |
| PIRSF | PIRSF036862 | |
| SUPFAM | SSF52833 | |
| TIGRFAMs | TIGR01130 TIGR01126 | |
| PROSITE | PS00014 PS00194 PS51352 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0061077 |
chaperone-mediated protein folding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003756 |
protein disulfide isomerase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0015037 |
peptide disulfide oxidoreductase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034976 |
response to endoplasmic reticulum stress |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000432607 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104864 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006457 |
protein folding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000432607 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0014002 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003756 |
protein disulfide isomerase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919080 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009986 |
cell surface |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0055114 |
oxidation-reduction process |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0015037 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003756 |
protein disulfide isomerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045454 |
cell redox homeostasis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003756 |
protein disulfide isomerase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009306 |
protein secretion |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016853 |
isomerase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005788 |
endoplasmic reticulum lumen |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042470 |
melanosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Alanen, HI et al. () pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family. Antioxid. Redox Signal. 8 283-91 PubMed GONUTS page
- ↑ 2.0 2.1 Holbrook, LM et al. (2010) Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Br. J. Haematol. 148 627-37 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 Mazzarella, RA et al. (1990) ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase. J. Biol. Chem. 265 1094-101 PubMed GONUTS page
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