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HUMAN:PCLI1
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | PID1 (synonyms: NYGGF4, PCLI1) | |
Protein Name(s) | PTB-containing, cubilin and LRP1-interacting protein
P-CLI1 Phosphotyrosine interaction domain-containing protein 1 Protein NYGGF4 | |
External Links | ||
UniProt | Q7Z2X4 | |
EMBL | AB075874 AY317148 AK000708 AK096636 AK125359 CH471063 BC040164 | |
CCDS | CCDS2471.1 CCDS42830.1 | |
RefSeq | NP_001094288.1 NP_060403.3 | |
UniGene | Hs.745038 | |
ProteinModelPortal | Q7Z2X4 | |
BioGrid | 120352 | |
STRING | 9606.ENSP00000375907 | |
PhosphoSite | Q7Z2X4 | |
DMDM | 74713284 | |
PaxDb | Q7Z2X4 | |
PeptideAtlas | Q7Z2X4 | |
PRIDE | Q7Z2X4 | |
Ensembl | ENST00000354069 ENST00000392054 ENST00000392055 ENST00000409462 | |
GeneID | 55022 | |
KEGG | hsa:55022 | |
UCSC | uc002vpr.4 uc002vps.4 uc002vpt.4 uc002vpu.4 | |
CTD | 55022 | |
GeneCards | GC02M229715 | |
HGNC | HGNC:26084 | |
HPA | HPA036103 | |
MIM | 612930 | |
neXtProt | NX_Q7Z2X4 | |
PharmGKB | PA162399462 | |
eggNOG | NOG260811 | |
GeneTree | ENSGT00510000048154 | |
HOGENOM | HOG000115472 | |
HOVERGEN | HBG054924 | |
InParanoid | Q7Z2X4 | |
OMA | TVIFHEP | |
OrthoDB | EOG7J4470 | |
PhylomeDB | Q7Z2X4 | |
ChiTaRS | PID1 | |
GenomeRNAi | 55022 | |
NextBio | 58400 | |
PRO | PR:Q7Z2X4 | |
Proteomes | UP000005640 | |
Bgee | Q7Z2X4 | |
CleanEx | HS_PID1 | |
ExpressionAtlas | Q7Z2X4 | |
Genevestigator | Q7Z2X4 | |
GO | GO:0005737 GO:0005634 GO:0071345 GO:0071398 GO:0071354 GO:0044320 GO:0071356 GO:0006112 GO:0070584 GO:2001170 GO:0090005 GO:2001274 GO:0046627 GO:0090298 GO:0001933 GO:2001171 GO:0070346 GO:0010628 GO:2000379 GO:0045944 GO:2000045 GO:0010635 GO:0051881 GO:2000377 | |
Gene3D | 2.30.29.30 | |
InterPro | IPR011993 IPR006020 | |
Pfam | PF14719 | |
PROSITE | PS01179 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0046325 |
negative regulation of glucose import |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001171 |
positive regulation of ATP biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001170 |
negative regulation of ATP biosynthetic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000379 |
positive regulation of reactive oxygen species metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:2000377 |
regulation of reactive oxygen species metabolic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1903077 |
negative regulation of protein localization to plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
happens_during:(GO:0032869) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071398 |
cellular response to fatty acid |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071354 |
cellular response to interleukin-6 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070584 |
mitochondrion morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070346 |
positive regulation of fat cell proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
part_of:(GO:0046325) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:O70343)|has_regulation_target:(UniProtKB:Q8VHJ7) |
Seeded From UniProt |
complete | ||
NOT|involved_in |
GO:0045444 |
fat cell differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010635 |
regulation of mitochondrial fusion |
ECO:0000305 |
curator inference used in manual assertion |
GO:0010628 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_regulation_target:(UniProtKB:Q811U4) |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006112 |
energy reserve metabolic process |
ECO:0000305 |
curator inference used in manual assertion |
GO:0010628 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001933 |
negative regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
happens_during:(GO:0032869) |
Seeded From UniProt |
complete | ||
involved_in |
GO:2001171 |
positive regulation of ATP biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:2000377 |
regulation of reactive oxygen species metabolic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071398 |
cellular response to fatty acid |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071354 |
cellular response to interleukin-6 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0071345 |
cellular response to cytokine stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0046325 |
negative regulation of glucose import |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0044320 |
cellular response to leptin stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q3UBG2 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042127 |
regulation of cell population proliferation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046627 |
negative regulation of insulin receptor signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Zhang, CM et al. (2009) Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt. Acta Pharmacol. Sin. 30 120-4 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Zhao, Y et al. (2010) Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes. Mol. Cell. Biochem. 340 41-8 PubMed GONUTS page
- ↑ Zhao, Y et al. (2010) [Expression of the NYGGF4 gene during human preadipocyte differentiation and the regulative role of tumor necrosis factor-alpha]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27 69-72 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Wang, B et al. (2006) Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation. Gene 379 132-40 PubMed GONUTS page
c
- Catarrhini
- GO:0044320 ! cellular response to leptin stimulus
- GO:0071398 ! cellular response to fatty acid
- GO:0071345 ! cellular response to cytokine stimulus
- GO:0071356 ! cellular response to tumor necrosis factor
- GO:0071354 ! cellular response to interleukin-6
- GO:0032869 ! cellular response to insulin stimulus
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
n
- GO:0046325 ! negative regulation of D-glucose import
- GO:2001170 ! negative regulation of ATP biosynthetic process
- GO:1903077 ! negative regulation of protein localization to plasma membrane
- GO:0046627 ! negative regulation of insulin receptor signaling pathway
- GO:0001933 ! negative regulation of protein phosphorylation
p
- GO:2000379 ! positive regulation of reactive oxygen species metabolic process
- GO:0070346 ! positive regulation of fat cell proliferation
- GO:2001171 ! positive regulation of ATP biosynthetic process
- GO:0010628 ! positive regulation of gene expression
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- Primates
r