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HUMAN:PCLI1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PID1 (synonyms: NYGGF4, PCLI1)
Protein Name(s) PTB-containing, cubilin and LRP1-interacting protein

P-CLI1 Phosphotyrosine interaction domain-containing protein 1 Protein NYGGF4

External Links
UniProt Q7Z2X4
EMBL AB075874
AY317148
AK000708
AK096636
AK125359
CH471063
BC040164
CCDS CCDS2471.1
CCDS42830.1
RefSeq NP_001094288.1
NP_060403.3
UniGene Hs.745038
ProteinModelPortal Q7Z2X4
BioGrid 120352
STRING 9606.ENSP00000375907
PhosphoSite Q7Z2X4
DMDM 74713284
PaxDb Q7Z2X4
PeptideAtlas Q7Z2X4
PRIDE Q7Z2X4
Ensembl ENST00000354069
ENST00000392054
ENST00000392055
ENST00000409462
GeneID 55022
KEGG hsa:55022
UCSC uc002vpr.4
uc002vps.4
uc002vpt.4
uc002vpu.4
CTD 55022
GeneCards GC02M229715
HGNC HGNC:26084
HPA HPA036103
MIM 612930
neXtProt NX_Q7Z2X4
PharmGKB PA162399462
eggNOG NOG260811
GeneTree ENSGT00510000048154
HOGENOM HOG000115472
HOVERGEN HBG054924
InParanoid Q7Z2X4
OMA TVIFHEP
OrthoDB EOG7J4470
PhylomeDB Q7Z2X4
ChiTaRS PID1
GenomeRNAi 55022
NextBio 58400
PRO PR:Q7Z2X4
Proteomes UP000005640
Bgee Q7Z2X4
CleanEx HS_PID1
ExpressionAtlas Q7Z2X4
Genevestigator Q7Z2X4
GO GO:0005737
GO:0005634
GO:0071345
GO:0071398
GO:0071354
GO:0044320
GO:0071356
GO:0006112
GO:0070584
GO:2001170
GO:0090005
GO:2001274
GO:0046627
GO:0090298
GO:0001933
GO:2001171
GO:0070346
GO:0010628
GO:2000379
GO:0045944
GO:2000045
GO:0010635
GO:0051881
GO:2000377
Gene3D 2.30.29.30
InterPro IPR011993
IPR006020
Pfam PF14719
PROSITE PS01179

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0046325

negative regulation of glucose import

PMID:19079291[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001171

positive regulation of ATP biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UBG2

P

Seeded From UniProt

complete

involved_in

GO:2001170

negative regulation of ATP biosynthetic process

PMID:20165904[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000379

positive regulation of reactive oxygen species metabolic process

PMID:20165904[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000377

regulation of reactive oxygen species metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UBG2

P

Seeded From UniProt

complete

involved_in

GO:1903077

negative regulation of protein localization to plasma membrane

PMID:19079291[1]

ECO:0000314

direct assay evidence used in manual assertion

P

happens_during:(GO:0032869)

Seeded From UniProt

complete

involved_in

GO:0071398

cellular response to fatty acid

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UBG2

P

Seeded From UniProt

complete

involved_in

GO:0071356

cellular response to tumor necrosis factor

PMID:20140872[3]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071356

cellular response to tumor necrosis factor

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UBG2

P

Seeded From UniProt

complete

involved_in

GO:0071354

cellular response to interleukin-6

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UBG2

P

Seeded From UniProt

complete

involved_in

GO:0071345

cellular response to cytokine stimulus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UBG2

P

Seeded From UniProt

complete

involved_in

GO:0070584

mitochondrion morphogenesis

PMID:20165904[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070346

positive regulation of fat cell proliferation

PMID:16815647[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3UBG2

P

Seeded From UniProt

complete

involved_in

GO:0046627

negative regulation of insulin receptor signaling pathway

PMID:19079291[1]

ECO:0000314

direct assay evidence used in manual assertion

P

part_of:(GO:0046325)

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20165904[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:O70343)|has_regulation_target:(UniProtKB:Q8VHJ7)

Seeded From UniProt

complete

NOT|involved_in

GO:0045444

fat cell differentiation

PMID:16815647[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010635

regulation of mitochondrial fusion

PMID:20165904[2]

ECO:0000305

curator inference used in manual assertion

GO:0010628

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:20165904[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

has_regulation_target:(UniProtKB:Q811U4)

Seeded From UniProt

complete

involved_in

GO:0006112

energy reserve metabolic process

PMID:20165904[2]

ECO:0000305

curator inference used in manual assertion

GO:0010628

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16815647[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

PMID:19079291[1]

ECO:0000314

direct assay evidence used in manual assertion

P

happens_during:(GO:0032869)

Seeded From UniProt

complete

involved_in

GO:2001171

positive regulation of ATP biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

P

Seeded From UniProt

complete

involved_in

GO:2000377

regulation of reactive oxygen species metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

P

Seeded From UniProt

complete

involved_in

GO:0071398

cellular response to fatty acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

P

Seeded From UniProt

complete

involved_in

GO:0071356

cellular response to tumor necrosis factor

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

P

Seeded From UniProt

complete

involved_in

GO:0071354

cellular response to interleukin-6

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

P

Seeded From UniProt

complete

involved_in

GO:0071345

cellular response to cytokine stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

P

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

P

Seeded From UniProt

complete

involved_in

GO:0046325

negative regulation of glucose import

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

P

Seeded From UniProt

complete

involved_in

GO:0044320

cellular response to leptin stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3UBG2
ensembl:ENSMUSP00000127716

C

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039112

P

Seeded From UniProt

complete

involved_in

GO:0046627

negative regulation of insulin receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039112

P

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039112

P

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

PMID:20165904[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Zhang, CM et al. (2009) Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt. Acta Pharmacol. Sin. 30 120-4 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Zhao, Y et al. (2010) Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes. Mol. Cell. Biochem. 340 41-8 PubMed GONUTS page
  3. Zhao, Y et al. (2010) [Expression of the NYGGF4 gene during human preadipocyte differentiation and the regulative role of tumor necrosis factor-alpha]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27 69-72 PubMed GONUTS page
  4. 4.0 4.1 4.2 Wang, B et al. (2006) Identification and characterization of NYGGF4, a novel gene containing a phosphotyrosine-binding (PTB) domain that stimulates 3T3-L1 preadipocytes proliferation. Gene 379 132-40 PubMed GONUTS page